Compartmental resection of peripheral nerve tumours with limb preservation in 16 dogs (1995–2011)

Stee, Lucinda van; Boston, Sarah E.; Teske, Erik; Meij, BR van der

doi:10.1016/j.tvjl.2017.07.002

Cited by 14 publications

(14 citation statements)

References 33 publications

(61 reference statements)

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“…The median survival times in dogs with root and peripheral nerve involvement is 5 and 12 mo, respectively, and the tumor relapse-free interval is 1 and 7.5 mo, respectively (Brehm et al ., 1995; Lorentz et al ., 2011); however, complete surgical resection can result in prolonged survival (Van Stee et al ., 2017). A regrowth of the tumor and metastasis 7 and 10 mo after the surgery, respectively, in our patient could be either due to the microscopic residual neoplastic cells or the invasiveness of the tumor itself.…”

Section: Discussionmentioning

confidence: 99%

“…In dogs, spinal nerves in the caudal cervical and cranial thoracic region and cranial nerves are most commonly affected. MPNSTs are described to be locally recurrent, and the overall long-term prognosis is considered to be poor (Brehm et al ., 1995; Dolera et al ., 2016; Hansen et al ., 2016; Swift et al ., 2017; Van Stee et al , 2017). Rarely, metastases of MPNSTs are reported in dogs (Stoica et al ., 2001; Garcìa et al ., 2004) or in other species, such as cows (Sartin et al ., 1996), goats (Ramirez et al ., 2007), and cats (Buza et al ., 2012).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog

Poli¹,

Calistri²,

Mandara³

et al. 2019

Open Vet J.

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An 8-yr-old French Bulldog was presented with a non-ambulatory tetraparesis. Magnetic resonance showed an intradurally located mass at the level of the right second cervical nerve root. The mass was surgically removed and the dog was ambulatory within 4 d. A 10-mo post-surgical imaging follow-up revealed a recurrence of the primary mass and another intradural/intramedullary mass at the level of the first thoracic vertebral body. Overall histological features were suggestive of malignant peripheral nerve sheath tumor (MPNST) for both masses. Immunohistochemistry was found weak but diffusely positive for S-100 and neurono-specific enolase for both masses. A diagnosis of primary MPNST for the cervical mass and of metastasis for the thoracic mass was made, possibly disseminated via the subarachnoidal space. To our knowledge, the central nervous system metastasis of MPNSTs has not previously been reported in dogs. The clinician should be aware that these tumors, albeit rarely, can metastasize to the central nervous system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog

Poli¹,

Calistri²,

Mandara³

et al. 2019

Open Vet J.

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“…1,2 Compartmental resection with preservation of the limb has also been described, with previous case reports of neurectomies having good results when performed on benign PNSTs, with good limb function reported postoperatively. 12,22 This was discussed with the owner but declined due to an increased risk of recurrence or likelihood of not achieving clean margins and also the impact of resection of the median nerve on limb function. Histopathology of the original biopsy found the tumour to be a mildly invasive, unencapsulated neoplasm.…”

Section: Discussionmentioning

confidence: 99%

A peripheral nerve sheath tumour in the median nerve of a dog

Anderson

Langley‐Hobbs

2022

Vet Record Case Reports

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A 6‐year‐old, female, spayed, flat‐coated retriever cross presented with a 4‐month history of progressive left thoracic limb lameness that was unresponsive to medical treatment. Initial advanced imaging with computed tomography did not identify a cause, and the dog was discharged on rest and analgesia. The dog re‐presented three weeks later with worsening lameness, discomfort and a painful, palpable mass on the medial aspect of the left thoracic limb just proximal to the elbow. Further investigations included electrodiagnostics and ultrasonography, which identified a lesion of the median nerve. A surgical biopsy was taken and histopathology diagnosed a peripheral nerve sheath tumour. The dog underwent surgery for thoracic limb amputation and nerve resection, with complete margins achieved. The dog went on to recover well with no signs of relapse 39 months later. This report describes the findings and treatment of a peripheral nerve sheath tumour in the thoracic limb of a dog.

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“…In dogs, PNSTs most commonly affect the brachial plexus and its contributing spinal nerves, and less frequently the pelvic limb (4). Typical clinical signs are insidious and include progressive lameness, monoparesis, muscle atrophy, a palpable mass and pain of variable severity (4)(5)(6)(7)(8)(9). A presumptive diagnosis is usually achieved via CT (7) or MRI (8), or less commonly ultrasound (10), with or without confirmation via biopsy or fine needle aspirate (11).…”

Section: Introductionmentioning

confidence: 99%

“…However, short diseasefree and survival times are not universal, and cases have been reported in which surgery has conferred prolonged survival and excellent quality of life. This appears to be particularly associated with complete mass resection (6). Where complete resection is not possible, there is some evidence that the use of adjunctive radiotherapy prolongs disease-free and survival times (13).…”

Section: Introductionmentioning

confidence: 99%

Case Report: A Novel Lateral Approach to the C7, C8, and T1 Intervertebral Foramina for Resection of Malignant Peripheral Nerve Sheath Neoplasia, Followed by Adjunctive Radiotherapy, in Three Dogs

Marsh¹,

Shimizu²,

Mason³

et al. 2022

Front. Vet. Sci.

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This case report describes the diagnosis, management and outcome of three dogs with peripheral nerve sheath tumors (PNSTs) involving the brachial plexus, C7 (case 1), C8 (case 2), and C8 and T1 (case 3) spinal nerves and nerve roots with intrathoracic invasion. Surgical resection required thoracic limb amputation and removal of the first rib, facilitating a novel lateral approach to the spinal nerves and foramina in all cases. This was followed by hemilaminectomy and rhizotomy in cases 1 and 2. Adjunctive radiotherapy was then performed in all dogs. All three dogs regained a good quality of life in the short-term following surgery. Two were euthanased after 3 and 10 months, following detection of a pulmonary mass in one case and multiple thoracic and abdominal masses in the other. The third dog was alive and well at the time of writing (7 months post-surgery). This surgical approach facilitated good access and allowed gross neoplastic tissue to be resected. The ease of surgical access was dependent, to a degree, on the size of the patient. This surgical approach can be considered in cases of PNSTs involving the caudal cervical or cranial thoracic spinal nerves and nerve roots. Adjunctive radiotherapy should be considered as part of a multi-modal approach to these challenging tumors due to the difficulty of achieving clean margins, particularly proximally, even with optimal surgical access.

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Compartmental resection of peripheral nerve tumours with limb preservation in 16 dogs (1995–2011)

Cited by 14 publications

References 33 publications

Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog

Central nervous system metastasis of an intradural malignant peripheral nerve sheath tumor in a dog

A peripheral nerve sheath tumour in the median nerve of a dog

Case Report: A Novel Lateral Approach to the C7, C8, and T1 Intervertebral Foramina for Resection of Malignant Peripheral Nerve Sheath Neoplasia, Followed by Adjunctive Radiotherapy, in Three Dogs

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