Pre-operative to post-operative serum carcinoembryonic antigen ratio is a prognostic indicator in colorectal cancer

Sun, Zhenqiang; Wang, Fuqi; Zhou, Quanbo; Yang, Shenghong; Sun, Xiantao; Wang, Guixian; Li, Zhen; Zhang, Zhiyong; Song, Junmin; Wang, Zhibin; Yuan, Weitang

doi:10.18632/oncotarget.17931

Cited by 16 publications

(13 citation statements)

References 36 publications

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“…Data from a very recent study of 2,035 surgically-treated colorectal cancer patients showed that the pre/post-CEA ratio is associated with lymphatic and distant metastasis, tumor stage, differentiation, and overall survival. 33 Carcinoembryonic antigen monitoring was found to result in better survival outcomes than detection by self-report in patients with recurrent colorectal cancer. 34 This study revealed that blood CEA levels ≥5 ng/mL prior to initiation of oxaliplatin-based chemotherapy were significantly associated with poorer response to chemotherapy and worse overall survival in patients with metastatic colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Association of XPD Asp312Asn polymorphism and response to oxaliplatin-based first-line chemotherapy and survival in patients with metastatic colorectal cancer

Liu¹,

Kong²,

Kong³

et al. 2019

Adv Clin Exp Med

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Background. Identification of biomarkers predicting a response to chemotherapeutic drugs would greatly ease the selection of personalized therapy. The protein xeroderma pigmentosum group D (XPD) functions in nucleotide excision repair (NER) to remove DNA cross-links and in the regulation of transcription. The potential role of the Asp312Asn polymorphism in predicting the response to chemotherapy has not been established. Objectives. This prospective study was designed to determine the role of the XPD Asp312Asn polymorphism in predicting the response to oxaliplatin-based first-line chemotherapy and survival in patients with metastatic colorectal cancer. Material and methods. A total of 106 patients treated with 2 cycles of either FOLFOX4 (n = 72) or XELOX (n = 34) regimen as the chemotherapy were enrolled. The genotype of XPD Asp312Asn polymorphism was analyzed using TaqMan probe-based real-time polymerase chain reaction (PCR). Logistic regression was applied to predict the response to treatment protocols. Cox regression models were applied to predict overall survival. Results. The overall response to chemotherapy was 57.6% (61/106). FOLFOX4 and XELOX regimens demonstrated comparable efficacy. The XPD Asp312Asn polymorphism was not associated with the response to either FOLFOX4 or XELOX regimen in univariate and in multivariate logistic regression analyses. Levels of carcinoembryonic antigen (CEA) ≥5 ng/mL and female gender were associated with a lack of response to FOLFOX4, but not to XELOX regimen. In a multivariate survival analysis, XPD Asp312Asn AA genotype, lack of response to chemotherapy, CEA ≥ 5 ng/mL, and age ≥65 were significantly associated with worse overall survival. Conclusions. The XPD Asp312Asn polymorphism is associated with overall survival, but it is not a biomarker in predicting the response to oxaliplatin-based first-line chemotherapy in patients with metastatic colorectal cancer.

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Section: Discussionmentioning

confidence: 99%

Association of XPD Asp312Asn polymorphism and response to oxaliplatin-based first-line chemotherapy and survival in patients with metastatic colorectal cancer

Liu¹,

Kong²,

Kong³

et al. 2019

Adv Clin Exp Med

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“…Concentrations of IL −6 (Thermo Fisher Scientific, Minneapolis, MA, USA), TGF -β1 (Abcam, Cambridge, MA), TNF -α (Abcam, Cambridge, MA) and IL-8 (Thermo Fisher Scientific, USA) were measured by enzyme-linked immunosorbent assay (ELISA) as previously described. 17…”

Section: Enzyme-linked Immunosorbent Assaymentioning

confidence: 99%

Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy

Shang

Wang

Zhang

et al. 2019

J Cellular Molecular Medi

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Diabetic nephropathy (DN) is characterized by inflammation of renal tissue. Glomerular endothelial cells (GEnCs) play an important role in inflammation and protein leakage in urine in DN patients. Chemerin and its receptor ChemR23 are inducers of inflammation. The aim of this study was to investigate the function of chemerin/ChemR23 in GEnCs of DN patients. Immunohistochemical staining and qRT‐PCR were used to measure the expression of chemerin, ChemR23 and inflammatory factors in renal tissues of DN patients. Db/db mice were used as animal model. ChemR23 of DN mice was knocked down by injecting LV3‐shRNA into tail vein. Inflammation, physiological and pathological changes in each group was measured. GEnCs were cultured as an in vitro model to study potential signalling pathways. Results showed that expression of chemerin, ChemR23 and inflammatory factors increased in DN patients and mice. LV3‐shRNA alleviated renal damage and inflammation in DN mice. GEnCs stimulated by glucose showed increased chemerin, ChemR23 and inflammatory factors and decreased endothelial marker CD31. Both LV3‐shRNA and SB203580 (p38 MAPK inhibitor) attenuated chemerin‐induced inflammation and injury in GEnCs. Taken together, chemerin/ChemR23 axis played an important role in endothelial injury and inflammation in DN via the p38 MAPK signalling pathway. Suppression of ChemR23 alleviated DN damage.

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“…In our subgroup analysis, we found RAP1A expression in primary CRC tissues could stratify the clinical outcome of both stage II and III patients, suggesting RAP1A as a promising prognostic indicator for identifying risk population within the same TNM stage. Since serum CEA is the most commonly detected parameter for CRC patients and numerous studies have proved the prognostic significance of its preoperative level, we next combined RAP1A expression with preoperative CEA level in prognostic evaluation [ 29 – 31 ]. As a result, we found high operative CEA level combined with high RAP1A expression was significantly associated with worse clinical outcome in CRC patients as compared with other phenotypes, and this association remains to be statistically significant in the subgroup analysis, except for OS in stage III patients.…”

Section: Discussionmentioning

confidence: 99%

High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway

Liu

Yan

et al. 2018

J Exp Clin Cancer Res

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BackgroundColorectal cancer (CRC) is a commonly diagnosed digestive malignancy worldwide. Ras-related protein 1A (RAP1A) is a member of the Ras superfamily of small GTPases and has been recently identified as a novel oncoprotein in several human malignancies. However, its specific role in CRC remains unclear.MethodIn this study, we firstly analyzed its expression and clinical significance in a retrospective cohort of 144 CRC patients. Then, cellular assays in vitro and in vivo were performed to clarify its biological role in CRC cells. Finally, microarray analysis was utilized to investigate the molecular mechanisms regulated by RAP1A in CRC progression.ResultsFirstly, RAP1A expression was abnormally higher in CRC tissues as compared with adjacent normal tissues, and significantly correlated tumor invasion. High RAP1A expression was an independent unfavourable prognostic factor for CRC patients. Combining RAP1A expression and preoperative CEA level contributed to a more accurate prognostic stratification in CRC patients. Secondly, knockdown of RAP1A dramatically inhibited the growth of CRC cells, while it was opposite for RAP1A overexpression. Finally, the microarray analysis revealed RAP1A promoted CRC growth partly through phosphatase and tensin homolog (PTEN)/forkhead box O3(FOXO3)/cyclin D1(CCND1) signaling pathway. FOXO3 overexpression could partly mimic the inhibitory effect of RAP1A knockdown in CRC growth. Moreover, FOXO3 overexpression inhibited CCND1 expression, but had no impact on RAP1A and PTEN expression.ConclusionRAP1A promotes CRC development partly through PTEN/FOXO3 /CCND1 signaling pathway. It has a great potential to be an effective clinical biomarker and therapeutic target for CRC patients.Electronic supplementary materialThe online version of this article (10.1186/s13046-018-0827-y) contains supplementary material, which is available to authorized users.

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Pre-operative to post-operative serum carcinoembryonic antigen ratio is a prognostic indicator in colorectal cancer

Cited by 16 publications

References 36 publications

Association of XPD Asp312Asn polymorphism and response to oxaliplatin-based first-line chemotherapy and survival in patients with metastatic colorectal cancer

Association of XPD Asp312Asn polymorphism and response to oxaliplatin-based first-line chemotherapy and survival in patients with metastatic colorectal cancer

Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in diabetic nephropathy

High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway

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