Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms

Losso, Jack N.; Finley, John W.; Karki, Namrata; Liu, Ann; Prudente, Alfredo; Tipton, Russell; Yu, Ying; Greenway, Frank L.

doi:10.1097/mjt.0000000000000584

Cited by 45 publications

(41 citation statements)

References 32 publications

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“…Dabei spielt die Senkung der Marker des oxidativen Stresses bei exzessivem Sport eine größere Rolle als bei mäßiger sportlicher Betätigung [38]. Darüber hinaus soll der Melatoningehalt von 85,2 µg pro Tagesdosis von 60 mL [20] zusammen mit dem Procyanidin-B 2 -Gehalt von 27 mg, der über die Indolamin-Dioxygenase den Abbau von Tryptophan hemmt [30], durch eine verlängerte Schlafzeit und verbesserte Schlafqualität die Erholungsphase nach sportlicher Betätigung verkürzen und optimieren, was die Leistungsfähigkeit der Sportler zusätzlich steigern soll.…”

Section: Diskussionunclassified

Wirksamkeit der Montmorency-Sauerkirsche bei sportlicher Aktivität

Chrubasik‐Hausmann¹

2020

Zeitschrift für Komplementärmedizin

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SummaryZiel der Untersuchung war es, die Evidenz der Wirksamkeit von Zubereitungen aus Prunus cerasus unter Berücksichtigung der Studienqualität und des untersuchten Wirkstoffs zu updaten. Nach einer Literaturrecherche wurden 19 randomisierte Doppelblindstudien in die Auswertung eingeschlossen. Die Extraktion und Beurteilung der Wirksamkeits-Evidenz erfolgte wie zuvor beschrieben.Wahrscheinlich wurden alle 19 Studien mit Montmorency-Sauerkirschprodukten durchgeführt, der Anthocyangehalt der Produkte variierte. Vier Studien mit konfirmatorischem Studiendesign hatten unterschiedliche Zielkriterien. Drei exploratorische Studien guter Qualität unterstützten nicht die positiven Ergebnisse von drei der konfirmatorischen Studien. Etwa zwei Drittel der Studien schlechter Qualität wiesen auf eine Überlegenheit der Montmorency-Produkte gegenüber Placebo hin. Die Evidenz der Wirksamkeit wird daher gegenwärtig als „mäßig” eingestuft.

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Section: Diskussionunclassified

Wirksamkeit der Montmorency-Sauerkirsche bei sportlicher Aktivität

Chrubasik‐Hausmann¹

2020

Zeitschrift für Komplementärmedizin

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“…While sleep clearly affects food choice and energy intake, whether the diet can influence sleep duration and quality is less certain. Intervention studies, which can establish causality, have been conducted for some specific foods: milk fortified with Horlicks powder (32) and melatonin-rich milk (33); cherry juice (34); B vitamins (35,36); and kiwifruit (37). The results of these studies have been summarized elsewhere (38,39) with the conclusion that these foods likely improve sleep quality.…”

Section: Sleep and The Dietmentioning

confidence: 99%

Reciprocal Roles of Sleep and Diet in Cardiovascular Health: a Review of Recent Evidence and a Potential Mechanism

St‐Onge

Zuraikat

2019

Curr Atheroscler Rep

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Purpose of review: This review investigates the potential bi-directional relation between sleep and diet in considering their contribution to cardiovascular health. We further explore the involvement of the gut microbiome in the relationships between poor sleep and dietary intakes and increased cardiovascular disease (CVD) risk. Recent findings: There is strong evidence that sleep restriction leads to unhealthy food choices and increased energy intake. The diet may impact sleep, as well. Epidemiological studies show that higher adherence to a Mediterranean dietary pattern predicts healthier sleep. One factor that could underlie these relationships is the gut microbiome. Although data are mixed, there is some evidence that sleep restriction can influence the composition of the gut microbiome in humans. Similarly, Mediterranean diets and other plant-rich diets are related to increased diversity of the microbiota. At present, few studies have investigated the influence of the microbiome on sleep; however, limited evidence from epidemiological and intervention studies suggest that the composition of the microbiome may relate to sleep quality. More research is needed to better understand the role of the microbiome in the multi-directional relationship between sleep, diet and CVD. Summary: There is growing evidence of a bi-directional relationship between sleep and the diet, which could act in concert to influence CVD risk. Diets such as the Mediterranean diet, comprised of high intakes of fruits, vegetables, and other plant-based foods, may promote healthy sleep and beneficial gut microflora. The gut microbiome may then underlie the relation between diet, sleep, and CVD risk.

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“…Moreover, the consumption of cereals enriched with tryptophan, adenosine-5′-phosphate, and uridine-5′-phosphate at night increased sleep efficiency in infants 8–16 months old with sleep problems [57]. In addition, a diet rich in cherries or cherry juice, which contain a high concentration of tryptophan, serotonin, and melatonin, can also produce beneficial effects on sleep/wake rhythms in both middle-aged and elderly people, for example, reducing insomnia or increasing sleep time and efficiency [58,59,60,61]. However, their beneficial effects are dependent on the type of cherry cultivar [58].…”

Section: Chrononutritionmentioning

confidence: 99%

Chrononutrition and Polyphenols: Roles and Diseases

et al. 2019

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Biological rhythms can influence the activity of bioactive compounds, and at the same time, the intake of these compounds can modulate biological rhythms. In this context, chrononutrition has appeared as a research field centered on the study of the interactions among biological rhythms, nutrition, and metabolism. This review summarizes the role of phenolic compounds in the modulation of biological rhythms, focusing on their effects in the treatment or prevention of chronic diseases. Heterotrophs are able to sense chemical cues mediated by phytochemicals such as phenolic compounds, promoting their adaptation to environmental conditions. This is called xenohormesis. Hence, the consumption of fruits and vegetables rich in phenolic compounds exerts several health benefits, mainly attributed to the product of their metabolism. However, the profile of phenolic compounds present in plants differs among species and is highly variable depending on agricultural and technological factors. In this sense, the seasonal consumption of polyphenol-rich fruits could induce important changes in the regulation of physiology and metabolism due to the particular phenolic profile that the fruits contain. This fact highlights the need for studies that evaluate the impact of these specific phenolic profiles on health to establish more accurate dietary recommendations.

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Pilot Study of the Tart Cherry Juice for the Treatment of Insomnia and Investigation of Mechanisms

Abstract: Cherry juice increased sleep time and sleep efficiency. Cherry juice procyanidin B-2 inhibited IDO, increased tryptophan availability, reduced inflammation, and may be partially responsible for improvement in insomnia.

Cited by 45 publications

References 32 publications

Wirksamkeit der Montmorency-Sauerkirsche bei sportlicher Aktivität

Wirksamkeit der Montmorency-Sauerkirsche bei sportlicher Aktivität

Reciprocal Roles of Sleep and Diet in Cardiovascular Health: a Review of Recent Evidence and a Potential Mechanism

Chrononutrition and Polyphenols: Roles and Diseases

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