The association between fatty acid index and in vitro fertilization outcomes

Am, Eskew; Kc, Wormer; Ml, Matthews; Hj, Norton; Ma, Papadakis; Bs, Hurst

doi:10.1007/s10815-017-1032-1

Cited by 20 publications

(24 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Standardized alimentary supplementation of omega-3-fatty acids before and during an in vitro fertilization therapy so far has not been subject of a well-designed randomized prospective study. Just few small, prospective cohort studies have examined the relationship between serum omega-3-fatty acid levels and IVF-success with conflicting results [16][17][18][19][20]. One of the first approaches to study the correlation of omega-3-fatty acid supplementation and the probability of a pregnancy is the PREPARE-trial by Kermack and co-workers [15], which has not been finished yet.…”

Section: Introductionmentioning

confidence: 99%

Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

View full text Add to dashboard Cite

Long-chain omega-3 fatty acids have been positively related with improvement of fertility in both women and men. Primary natural source of omega-3-fatty acids is seafood. As this also can bei the source of toxicants like f.e. lead, mercury and cadmium, reproductive benefits may be counteracted. Therefore, our approach was to supplement pharmaceutical grade omega-3-fatty acids in order to assess potential benefits of omega-3-fatty acids on modulation of IVFsuccess by dietary measures in a well-defined group of patients of a German Fertility Centre. A group of 52 IVF-patients with a history of at least two miscarriages or unsuccessful in vitro fertilization approaches received periconceptual omega-3-fatty acid supplementation for a time period of at least 3 weeks. The "historical" control group, consisting of 1109 patients without omega-3-fatty acid supplementation, was generated out of the Fertility Centre´s patient database. The same inclusion criteria (history of at least two miscarriages or unsuccessful in vitro fertilization approaches) were applied for both groups. Omega-3-fatty acid supplementation lead to significantly enhanced in vitro fertilization success rates as well as to reduction of miscarriage rates compared to patients of the control group. The results encourage to design further agematched, double-blinded prospective studies in order to verify a positive influence of dietary intervention and lifestyle modification on fertility rates.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Bareksei¹,

Häfner²,

Pfeiffer³

et al. 2019

IJCEMS

View full text Add to dashboard Cite

show abstract

“…Cholesterol serves as a substrate for the synthesis of the plasma membrane and steroid hormones indispensable for the growth of activated steroidogenic cells (DeAngelis, Roy‐O'Reilly, & Rodriguez, ). Meanwhile, fatty acids, as crucial components of membrane lipids and substrates for prostaglandin synthesis, function in cell division, and oocyte maturation (Eskew et al, ). There remains an interesting area of cholesterol and fatty acid metabolic pathways and their impact on human reproductive health.…”

Section: Discussionmentioning

confidence: 99%

Peptidomic analysis of blastocyst culture medium and the effect of peptide derived from blastocyst culture medium on blastocyst formation and viability

Shi

Wang

et al. 2019

Molecular Reproduction Devel

View full text Add to dashboard Cite

High-quality in vitro human embryo culture medium can improve the blastocyst formation rate and blastocyst quality and be beneficial for the clinical application of single blastocyst transfer. Mammalian embryos can secrete protein products into the surrounding medium. As a group of bioactive molecules and degraded proteins, peptides have been shown to participate in various biological processes.Using liquid chromatography-tandem mass spectrometry, we performed comparative peptidomic analysis of human culture medium in blastocyst formation and nonblastocyst-formation groups. A total of 201 differentially expressed peptides originating from 157 precursor proteins were identified. Among these, a peptide derived from HERC2 (peptide derived from blastocyst culture medium[PDBCM]) passed through the zona pellucida, was distributed on the perivitelline space, was absent in arrest embryos and highly expressed in high-quality blastocysts compared with low-quality blastocysts, and significantly promoted blastocyst formation in a concentration-dependent manner. These results indicate that PDBCM may be a novel biomarker for predicting blastocyst formation and viability. The mechanism remains unclear and needs to be explored in the future. K E Y W O R D Sbiomarker, blastocyst culture medium, blastocyst formation, peptide derived from blastocyst culture medium, peptidomic analysis *Ji and Shi contributed equally to this study.

show abstract

“…No correlation between omega-3 PUFA index and IVF outcomes, such as number of oocytes retrieved, embryo grade or clinical pregnancy, was found in another small study (n = 60) (Eskew et al, 2017). Mirabi et al (2017) measured serum and follicular fluid level of fatty acids in 105 women undergoing IVF.…”

Section: Omega-3 Pufas In Assisted Reproductive Technologiesmentioning

confidence: 96%

“…It is unclear why studies in IVF have yielded conflicting results on the relationship between PUFA intake and IVF outcomes, but it may be due, in part, to the combination of a small number of cycles in each study and the variability of studies. In total, five studies (556 cycles) reported a clinical outcome of IVF: two studies showed a positive effect of omega-3 PUFAs, especially EPA, on clinical pregnancy (Mirabi et al, 2017;Chiu et al, 2018), one found no correlation (Eskew et al, 2017), and one found a negative effect of ALA (Jungheim et al, 2011); however, in a larger follow-up study from the same group, no detrimental effect was found nor was a correlation found between PUFAs and the chance of becoming pregnant, although a higher ratio of linoleic acid-ALA increased this chance (Jungheim et al, 2013). Marked differences exist between the studies.…”

Section: Yesmentioning

confidence: 99%

“…Marked differences exist between the studies. For example, time of blood sampling ranged from days 3-9 of stimulation (Chiu et al, 2018), day 8 (Eskew et al, 2017), day of oocyte retrieval (Jungheim et al, 2013) or was not specified (Mirabi et al, 2017). Differences in patient characteristics were present between studies, e.g., in BMI (27.7 versus 24.4 kg/m 2 ) (Jungheim et al, 2013;Chiu et al, 2018), and analytical approaches also differed, especially for assessment of linoleic acid-ALA ratios (Chiu et al, 2018).…”

Section: Yesmentioning

confidence: 99%

See 1 more Smart Citation

Omega-3 polyunsaturated fatty acids and IVF treatment

Lass¹,

Belluzzi

2019

Reproductive BioMedicine Online

View full text Add to dashboard Cite

Omega-3 polyunsaturated fatty acids (PUFAs) are essential fatty acids, derived mostly from fish oil, that have a significant anti-inflammatory effect. Data from animal studies support their role in the reproductive mechanism, and recent human studies suggest a positive effect on sperm quality and natural conception. Their general role in human fertility, and specifically in IVF treatment, however, is not clear. A few small, prospective cohort studies have examined the relationship between serum PUFAs and outcome measures and success in IVF, with conflicting results. Some have demonstrated a better chance of live birth with increased levels of serum omega-3 PUFAs, whereas others have failed to show such a correlation, and the reasons for such differences are not clear. Moreover, no welldesigned, published studies have assessing whether the administration of omega-3 PUFAs before IVF treatment can improve clinical pregnancy and live birth rates. The development of safe and well-tolerated pharmaceutical forms of the active omega-3 PUFAs, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), mean that assessment of this question is now possible and future studies are warranted.

show abstract

The association between fatty acid index and in vitro fertilization outcomes

Cited by 20 publications

References 30 publications

Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Effects of Periconceptual Omega-3-Fatty Acid Supplementation on in Vitro Fertilization Success and Miscarriage Rates in Patients of a German Fertility Centre

Peptidomic analysis of blastocyst culture medium and the effect of peptide derived from blastocyst culture medium on blastocyst formation and viability

Omega-3 polyunsaturated fatty acids and IVF treatment

Contact Info

Product

Resources

About