Trz1, the long form RNase Z from yeast, forms a stable heterohexamer with endonuclease Nuc1 and mutarotase

Ma, Miao; Sierra-Gallay, I. Li de la; Lazar, Noureddine; Pellegrini, Olivier; Lepault, Jean; Condon, Ciarán; Durand, Dominique; Tilbeurgh, Herman van

doi:10.1042/bcj20170435

Cited by 4 publications

(4 citation statements)

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“…The RNase ZS enzymes have been extensively studied showing the domains and motifs important for catalysis and tRNA binding [ 64 , 65 ]. In the case of RNase ZL that are present in mitochondria, structural studies of the yeast dual localized TRZ1 (mitochondria and nucleus) align with the biochemical studies [ 62 , 66 ]. The 3D structure of TRZ1 confirms that RNase ZL are probably a duplication-fusion of RNase ZS.…”

Section: Mitochondrial Rnases Involved In Rna Maturationsupporting

confidence: 57%

How RNases Shape Mitochondrial Transcriptomes

Cartalas

Coudray

Gobert

2022

IJMS

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Mitochondria are the power houses of eukaryote cells. These endosymbiotic organelles of prokaryote origin are considered as semi-autonomous since they have retained a genome and fully functional gene expression mechanisms. These pathways are particularly interesting because they combine features inherited from the bacterial ancestor of mitochondria with characteristics that appeared during eukaryote evolution. RNA biology is thus particularly diverse in mitochondria. It involves an unexpectedly vast array of factors, some of which being universal to all mitochondria and others being specific from specific eukaryote clades. Among them, ribonucleases are particularly prominent. They play pivotal functions such as the maturation of transcript ends, RNA degradation and surveillance functions that are required to attain the pool of mature RNAs required to synthesize essential mitochondrial proteins such as respiratory chain proteins. Beyond these functions, mitochondrial ribonucleases are also involved in the maintenance and replication of mitochondrial DNA, and even possibly in the biogenesis of mitochondrial ribosomes. The diversity of mitochondrial RNases is reviewed here, showing for instance how in some cases a bacterial-type enzyme was kept in some eukaryotes, while in other clades, eukaryote specific enzymes were recruited for the same function.

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Section: Mitochondrial Rnases Involved In Rna Maturationsupporting

confidence: 57%

How RNases Shape Mitochondrial Transcriptomes

Cartalas

Coudray

Gobert

2022

IJMS

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“…Inhibition of 5 ′ -processing when mitochondrial tRNase Z L activity is compromised has also been observed in S. cerevisiae (Skowronek et al 2014). It is very likely that trz2 inactivation may compromise the mt-RNase P activity since both mt-tRNA 5 ′ -and 3 ′end processing enzymes may be integrated into a stable protein supercomplex and the tRNA 5 ′ -and 3 ′ -end processing may be somehow linked (Ma et al 2017b). Unexpectedly, the levels of some mature mt-tRNAs are not affected upon trz2 inactivation.…”

Section: Discussionmentioning

confidence: 90%

The S. pombe mitochondrial transcriptome

Shang

Yang

Zou

et al. 2018

RNA

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Mitochondrial gene expression is largely controlled through post-transcriptional processes including mitochondrial RNA (mt-RNA) processing, modification, decay, and quality control. Defective mitochondrial gene expression results in mitochondrial oxidative phosphorylation (OXPHOS) deficiency and has been implicated in human disease. To fully understand mitochondrial transcription and RNA processing, we performed RNA-seq analyses of mt-RNAs from the fission yeast RNA-seq analyses show that the abundance of mt-RNAs vary greatly. Analysis of data also reveals mt-RNA processing sites including an unusual RNA cleavage event by mitochondrial tRNA (mt-tRNA) 5'-end processing enzyme RNase P. Additionally, this analysis reveals previously unknown mitochondrial transcripts including the-derived fragment, mitochondrial small RNAs (mitosRNAs) such as mt-tRNA-derived fragments (mt-tRFs) and mt-tRNA halves, and mt-tRNAs marked with 3'-CCACCA/CCACC in Finally, RNA-seq reveals that inactivation of encoding mitochondrial tRNA 3'-end processing enzyme globally impairs mt-tRNA 3'-end processing, inhibits mt-mRNA 5'-end processing, and causes accumulation of unprocessed transcripts, demonstrating the feasibility of using RNA-seq to examine the protein known or predicted to be involved in mt-RNA processing in Our work uncovers the complexity of a fungal mitochondrial transcriptome and provides a framework for future studies of mitochondrial gene expression using as a model system.

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“…A bioinformatics analysis of the budding yeast's entire genome for finding the putative target of transcription factor "GCN4 (a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences)" has shown that GCN4 regulates YMR099C (Schuldiner et al, 1998). Trz1 (a tRNA 3' end processing endonuclease), Nuc1 (a mitochondrial nuclease), and YMR099C form highly stable heterohexamers consisting of two copies of each of the three subunits, which suggests that YMR099C and Trz1 may regulate apoptotic nucleases activity (Ma et al, 2017). Glucose-6-phosphate is an important metabolite in multiple metabolic pathways, such as glycolysis and the pentose phosphate pathway He et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome & Metabolic Profiling: An Insight Into the Abiotic Stress Response Crosstalk in Plants

Yadav,

Li,

M. Mulet

2024

Frontiers Research Topics

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Frontiers is more than just an open access publisher of scholarly articles: it is a pioneering approach to the world of academia, radically improving the way scholarly research is managed. The grand vision of Frontiers is a world where all people have an equal opportunity to seek, share and generate knowledge. Frontiers provides immediate and permanent online open access to all its publications, but this alone is not enough to realize our grand goals. Frontiers journal seriesThe Frontiers journal series is a multi-tier and interdisciplinary set of openaccess, online journals, promising a paradigm shift from the current review, selection and dissemination processes in academic publishing. All Frontiers journals are driven by researchers for researchers; therefore, they constitute a service to the scholarly community. At the same time, the Frontiers journal series operates on a revolutionary invention, the tiered publishing system, initially addressing specific communities of scholars, and gradually climbing up to broader public understanding, thus serving the interests of the lay society, too. Dedication to qualityEach Frontiers article is a landmark of the highest quality, thanks to genuinely collaborative interactions between authors and review editors, who include some of the world's best academicians. Research must be certified by peers before entering a stream of knowledge that may eventually reach the public -and shape society; therefore, Frontiers only applies the most rigorous and unbiased reviews. Frontiers revolutionizes research publishing by freely delivering the most outstanding research, evaluated with no bias from both the academic and social point of view. By applying the most advanced information technologies, Frontiers is catapulting scholarly publishing into a new generation. What are Frontiers Research Topics?Frontiers Research Topics are very popular trademarks of the Frontiers journals series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area.

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Trz1, the long form RNase Z from yeast, forms a stable heterohexamer with endonuclease Nuc1 and mutarotase

Cited by 4 publications

References 51 publications

How RNases Shape Mitochondrial Transcriptomes

How RNases Shape Mitochondrial Transcriptomes

The S. pombe mitochondrial transcriptome

Transcriptome & Metabolic Profiling: An Insight Into the Abiotic Stress Response Crosstalk in Plants

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