Metabolic biomarkers in community obese children: effect of obstructive sleep apnea and its treatment

Alonso-Álvarez, María Luz; Terán-Santos, Joaquín; Martínez, Mónica González; Cordero-Guevara, José; Jurado-Luque, María José; Corral‐Peñafiel, Jaime; Durán-Cantolla, Joaquín; Carbajo, Estrella Ordax; Masa-Jiménez, Fernando; Kheirandish‐Gozal, Leila; Gozal, David

doi:10.1016/j.sleep.2017.06.002

Cited by 34 publications

(18 citation statements)

References 47 publications

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“…Out of the 62 subjects with OSA, 10 were started on CPAP corresponding to an incidence of 16%. Indication for CPAP was defined as moderate-to-severe OSA defined as ASI > 10 without endoscopic evidence of adenotonsillar hypertrophy ( 37 ).…”

Section: Cpap In Obese Childrenmentioning

confidence: 99%

“…This last finding is intriguing and clinically relevant suggesting increased energy expenditure during sleep ( 32 ). Alonso-Alvarez et al ( 37 ) studied the effects of different OSA treatments on several markers of the metabolic syndrome. Only a limited number of patients on CPAP were included.…”

Section: Cpap In Obese Childrenmentioning

confidence: 99%

“…Only a limited number of patients on CPAP were included. This might explain why no significant effects of CPAP directly on metabolic markers were observed ( 37 ). Another small-scale study in 11 obese children on CPAP therapy only found a change in leptin levels on CPAP treatment ( 44 ).…”

Section: Cpap In Obese Childrenmentioning

confidence: 99%

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Long Term Continuous Positive Airway Pressure and Non-invasive Ventilation in Obstructive Sleep Apnea in Children With Obesity and Down Syndrome

Verhulst

2020

Front. Pediatr.

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This review will focus on non-invasive ventilation (NIV) and continuous positive airway pressure (CPAP) therapy in children with obstructive sleep apnea (OSA) due to obesity and underlying syndromes. These children have a high prevalence of OSA and residual OSA after adenotonsillectomy. Therefore, a high proportion of these children are treated with CPAP or NIV. This review will focus on treatment selection tools and will subsequently cover specific issues on CPAP treatment in obese and syndromic children with a major focus on Down syndrome.

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Section: Cpap In Obese Childrenmentioning

confidence: 99%

Section: Cpap In Obese Childrenmentioning

confidence: 99%

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Long Term Continuous Positive Airway Pressure and Non-invasive Ventilation in Obstructive Sleep Apnea in Children With Obesity and Down Syndrome

Verhulst

2020

Front. Pediatr.

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“…[3][4][5][6][7] In adults, it has been clearly demonstrated that OSA, the associated intermittent nocturnal hypoxemia and other sleep disturbances, has deleterious clinical consequences contributing to obesity, metabolic syndrome and cardiovascular and renal diseases [8][9][10][11][12] with some of this evidence previously synthesised. [13][14][15][16] In children, emerging data over the past few years also suggest these associations although available studies have revealed conflicting results [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31] and evidence synthesis is less available.…”

Section: Introductionmentioning

confidence: 99%

“… 18 36 37 Evidence showing the implications of treating obesity to ameliorate OSA has started to emerge. 38 39 As well, the effect of treating OSA on obesity management has also been explored by more recent studies, 30 40–43 justifying the need of a systematic review.…”

Section: Introductionmentioning

confidence: 99%

Does obstructive sleep apnoea contribute to obesity, hypertension and kidney dysfunction in children? A systematic review protocol

et al. 2020

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IntroductionChildhood obstructive sleep apnoea (OSA) is a highly prevalent disorder that may directly contribute to the development of obesity, hypertension and renal injury. Although those associations seem to be clearer in adults, studies in children have revealed conflicting results and updated synthesis of the evidence is lacking. The aim of this systematic review is to summarise the available evidence on the effect of OSA on obesity, systemic blood pressure and kidney function, to help to elucidate whether respiratory interventions to correct OSA would have the potential to improve those outcomes.Methods and analysisA systematic literature review search was created by a medical librarian and peer-reviewed by a second librarian prior to running. Ovid Medline, Ovid Embase, CINAHL via EbscoHOST, Wiley Cochrane Library and ProQuest Dissertations and Theses Global were searched on 25 February 2020. Titles and abstracts will be screened by two independent reviewers for inclusion, followed by full-text screening of relevant articles. Studies in children will be included if they report data on OSA and weight, systemic blood pressure or kidney parameters. The extracted data will be combined for analysis and the information subcategorised in groups based on outcome. Risk of bias will be determined using tools specific to study methodology and certainty of the evidence using the Grading of Recommendations, Assessment, Development and Evaluations approach.Ethics and disseminationThis study will provide essential information for healthcare professionals to better understand the relationship between childhood OSA and changes in body mass index, systemic blood pressure and kidney function indicators. Our findings will be disseminated through conferences and publications. The results of this review may guide the initiation of new strategies and the development of future research studies. This research did not involve human subjects and therefore did not undergo research ethical review.PROSPERO registration numberCRD42020171186.

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Laboratory Tests in Pediatric Sleep Medicine

Kheirandish‐Gozal

Gozal

2021

Pediatric Sleep Medicine

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Metabolic biomarkers in community obese children: effect of obstructive sleep apnea and its treatment

Abstract: Concurrent obesity and OSAS could promote metabolic and inflammatory alterations, and the latter appeared to be sensitive to OSAS treatment outcomes. ClinicalTrials.gov Identifier: NCT01322763.

Cited by 34 publications

References 47 publications

Long Term Continuous Positive Airway Pressure and Non-invasive Ventilation in Obstructive Sleep Apnea in Children With Obesity and Down Syndrome

Long Term Continuous Positive Airway Pressure and Non-invasive Ventilation in Obstructive Sleep Apnea in Children With Obesity and Down Syndrome

Does obstructive sleep apnoea contribute to obesity, hypertension and kidney dysfunction in children? A systematic review protocol

Laboratory Tests in Pediatric Sleep Medicine

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