Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the region

Rajwani, Jahanara; Klinger, Christen M.; Arango, Eliana; Arroyo, Maria Isabel; Sabbagh, Audrey; Maestre, Amanda; Dacks, Joel B.; Gnidehou, Sédami; Yanow, Stephanie K.

doi:10.1016/j.meegid.2017.09.003

Cited by 4 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This same study suggests that the plasmodia circulating in the country come from Africa, and are genetically different from those reported in other South American countries. 35…”

Section: Genetic Variation Of P Vivax and P Falciparum In Mapmentioning

confidence: 99%

Overview of Epidemiology of Malaria Associated with Pregnancy in Northwestern Colombia, 1985-2020

Cardona‐Arias

2021

JCD

View full text Add to dashboard Cite

Background: Knowledge about malaria associated with pregnancy (MAP) is scarce in Latin America and Colombia. Methodology: This paper presents an overview of studies captained in Pubmed, Lilacs, GoogleScholar and thesis repositories from six Colombian universities and bibliographic references of manuscripts. Results: The following topics have been described: study sites, infectious agents, genetic variation of Plasmodium in MAP, vector resistance to insecticides, incubation period, natural susceptibility and resistance to infection, immunity in MAP, frequency, coexistence of gestational (GM) and placental (PM) malaria, associated factors, efficacy of antimalarial treatment, material living conditions in MAP. The MAP has a high prevalence, with a high frequency of submicroscopic infections. There are cases of MAP due to P. falciparum, P. vivax, or both. Monotherapy with chloroquine or amodiaquine for MAP for P. vivax has efficacy greater than 95% and artemether-lumefantrine or artesunate-mefloquine 100% for P. falciparum. There are high rates of anemia in pregnancies (30-70%). In “The Region,” there is no problem of resistance of vectors to insecticides. MAP occurs in poor territories, with interaction of food insecurity, chronic malnutrition, dissatisfaction of basic needs, intestinal parasites, violence and abuse of human rights. Conclusions: MAP study is just beginning in Colombia; there are no programmes that effectively operate to detect and solve this problem; Government agencies, international health organizations, and private companies should finance the multidisciplinary and comprehensive research (natural and social) of the MAP, in order to know its main characteristics throughout the country and use that knowledge as a basis to seek solutions.

show abstract

“…This same study suggests that the plasmodia circulating in the country come from Africa, and are genetically different from those reported in other South American countries. 35…”

Section: Genetic Variation Of P Vivax and P Falciparum In Mapmentioning

confidence: 99%

Overview of Epidemiology of Malaria Associated with Pregnancy in Northwestern Colombia, 1985-2020

Cardona‐Arias

2021

JCD

View full text Add to dashboard Cite

show abstract

“…The latter hypothesis has been recently demonstrated in a report showing that naturally acquired host immune defenses to different P. falciparum antigens act in an allele-specific manner to block specific parasite haplotypes from establishing blood-stage infections in infants and children, suggesting that vaccines targeting polymorphic parasite antigens must account for allele-specific immunity (25). Many studies have demonstrated that VAR2CSA displays extensive diversity between parasites/alleles, contains conserved interspersed regions shared between alleles (26)(27)(28), and is targeted by cross-reactive antibodies acquired during PM (29)(30)(31)(32). However, the differential susceptibility of different CSAbinding parasites to binding inhibition and opsonizing antibody functions has not previously been established.…”

mentioning

confidence: 91%

Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region

et al. 2019

View full text Add to dashboard Cite

During pregnancy, Plasmodium falciparum-infected erythrocytes (IE) accumulate in the intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit inflammatory responses that are associated with poor pregnancy outcomes. Primigravidae lack immunity to IE that sequester in the placenta and thus are susceptible to placental malaria (PM). Women become resistant to PM over successive pregnancies as antibodies to placental IE are acquired. Here, we assayed plasma collected at delivery from Malian and Tanzanian women of different parities for total antibody levels against recombinant VAR2CSA antigens (FCR3 allele), and for surface reactivity and binding inhibition and opsonizing functional activities against IE using two CSA-binding laboratory isolates (FCR3 and NF54). Overall, antibody reactivity to VAR2CSA recombinant proteins and to CSA-binding IE was higher in multigravidae than in primigravidae. However, plasma from Malian gravid women reacted more strongly with FCR3 whereas Tanzanian plasma preferentially reacted with NF54. Further, acquisition of functional antibodies was variant dependent: binding inhibition of P. falciparum strain NF54 (P < 0.001) but not of the strain FCR3 increased significantly with parity, while only opsonizing activity against FCR3 (P < 0.001) increased significantly with parity. In addition, opsonizing and binding inhibition activities of plasma of multigravidae were significantly correlated in assays of FCR3 (r = 0.4, P = 0.01) but not of NF54 isolates; functional activities did not correlate in plasma from primigravidae. These data suggest that IE surface-expressed epitopes involved in each functional activity differ among P. falciparum strains. Consequently, geographic bias in circulating strains may impact antibody functions. Our study has implications for the development of PM vaccines aiming to achieve broad protection against various parasite strains.

show abstract

Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine

Gill

Chakraborti

Bharti

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

show abstract

Genetic analysis of ID1-DBL2X predicts its validity as a vaccine candidate in Colombia and supports at least two independently introduced Plasmodium falciparum populations in the region

Cited by 4 publications

References 42 publications

Overview of Epidemiology of Malaria Associated with Pregnancy in Northwestern Colombia, 1985-2020

Overview of Epidemiology of Malaria Associated with Pregnancy in Northwestern Colombia, 1985-2020

Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region

Structural insights into global mutations in the ligand-binding domain of VAR2CSA and its implications on placental malaria vaccine

Contact Info

Product

Resources

About