Effects of catechins and caffeine on the development of atherosclerosis in mice

Abstract

Atherosclerosis is one of the diseases related to metabolic syndrome which is caused by obesity. Previous reports have shown that green tea and its components have anti-obesity effect. We examined whether catechins and caffeine can prevent the development of atherosclerosis by oral administration, singly or in combination to the atherosclerosis model mice. Results demonstrated that the number of atherosclerotic regions in the aorta was significantly reduced by the combined treatment, and the atherosclerotic area was also improved. Serum HDL-C increased by caffeine single treatment, but no effect on the TG and TC by any treatments. Moreover, ECG illuviated to atheromatous lesions in aorta and the illuviation was enhanced by caffeine. The mRNA expression levels of LOX-1 and TNF-α showed a tendency to suppress by the combined treatment. These results indicated that the combined administration of catechins and caffeine has the inhibitory effect on the development of atherosclerosis in mice.

Chemical Composition, Antioxidant and Enzyme Inhibitory Properties of Different Extracts Obtained from Spent Coffee Ground and Coffee Silverskin

“…Thus, caffeine could be considered as a protective agent against oxidative stress. Similar positive effects for caffeine were also reported by Liu et al [ 58 ] on the development of atherosclerosis in mice. Thus, SCG EtOH:H 2 O could be considered a valuable raw material with a high level of caffeine.…”

Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease

“…(−)-Epicatechin, a polyphenol found in fruits, vegetables and tea, has protective effects in many conditions including insulin resistance [117] and atherosclerosis [118,119]. The protective effect of tea polyphenols in cardiovascular health was recently reviewed by others [120,121].…”

Candidate SNP Markers of Atherogenesis Significantly Shifting the Affinity of TATA-Binding Protein for Human Gene Promoters Show Stabilizing Natural Selection as a Sum of Neutral Drift Accelerating Atherogenesis and Directional Natural Selection Slowing It

“…Human gene ATM has 14 and 16 unannotated SNPs, which can respectively decrease and increase the amount of the ATM serine/threonine kinase encoded by this gene (Table 8). Our keyword search through PubMed [38] yielded biomedical data on this enzyme's excess as an atheroprotector [167], and there is an ATM-deficient murine model of human atherosclerosis [168][169][170][171][172]. With this in mind, we propose 14 and 16 candidate SNP markers enhancing (e.g., rs773550815:g) and weakening (e.g., rs773550815:t) atherogenesis (Table 8).…”

“…With this in mind, we propose 14 and 16 candidate SNP markers enhancing (e.g., rs773550815:g) and weakening (e.g., rs773550815:t) atherogenesis (Table 8). In particular, this time using PubMed [38], we found nutritionists' report that postprandial tea is an atheroprotector in contrast to proatherogenic effects of postprandial coffee [169] (Table 8). Table 8, we did not find any neutral drift (row 5 of Table 1: n < = 29 and n > = 48 at p < 0.02) or predominance of candidate SNP markers accelerating atherogenesis (row 5 of Table 1: n ↑ = 27 and n ↓ = 50 at p < 0.01).…”