Epigenetic toxicity of environmental chemicals upon exposure during development - Bisphenol A and valproic acid may have epigenetic effects

Ideta-Otsuka, Maky; Igarashi, Katsuhide; Narita, Minoru; Hirabayashi, Yoko

doi:10.1016/j.fct.2017.09.014

Cited by 24 publications

(14 citation statements)

References 21 publications

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“…Reprogramed DNA methylation levels during development can be maintained through cell division and influence disease status in later life. Therefore, it is important to investigate the DNA methylation changes resulting from early life exposures (Ideta-Otsuka et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Tissue- and Sex-Specific DNA Methylation Changes in Mice Perinatally Exposed to Lead (Pb)

et al. 2020

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Lead (Pb) is a well-known toxicant that interferes with the development of a child's nervous and metabolic systems and increases the risk of developing diseases later in life. Although studies have investigated epigenetic effects associated with Pb exposure, knowledge of genome-wide changes with in vivo low dose perinatal Pb exposure in multiple tissues is limited. Within the Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription (TaRGET II) consortium, we utilized a mouse model to investigate tissue-and sex-specific DNA methylation. Dams were assigned to control or Pb-acetate water, respectively. Exposures started 2 weeks prior to mating and continued until weaning at post-natal day 21 (PND21). Liver and blood were collected from PND21 mice, and the DNA methylome was assessed using enhanced reduced representation bisulfite sequencing (ERRBS). We identified ∼1000 perinatal Pb exposure related differentially methylated cytosines (DMCs) for each tissue-and sexspecific comparison, and hundreds of tissue-and sex-specific differentially methylated regions (DMRs). Several mouse imprinted genes were differentially methylated across both tissues in males and females. Overall, our findings demonstrate that perinatal Pb exposure can induce tissue-and sex-specific DNA methylation changes and provide information for future Pb studies in humans.

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Section: Introductionmentioning

confidence: 99%

Tissue- and Sex-Specific DNA Methylation Changes in Mice Perinatally Exposed to Lead (Pb)

et al. 2020

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“…The long-term effects of exposure to environmental chemicals can be predictable more accurately using gene expression profiling. Recently a number of studies have reported gene regulation by small environmental chemicals, both natural and synthetic [ 23 , 24 , 32 , 33 ]. In a previous study, vinyl benzoate, a synthetic, hydrophobic compound with a notable cytotoxicity (LC 50 = 0.08% in HEK293), showed a marked reduction in HSP70 expression in both RNA and protein levels [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

In Vitro Evaluation of Lignin-Containing Nanocellulose

et al. 2020

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The increasing importance of environmental sustainability has led to the development of new materials that are environmentally friendly, functional, and cost-effective. Lignin-containing cellulose nanomaterials are a common example of these. The advantages of lignocelluloses include their renewability, sustainability, and functionality combined with molecular rigidity and enhanced hydrophobicity. In order to valorize these beneficial traits from lignin-containing nanocellulose, various approaches have been examined in industrial applications. However, the safety of these materials has not been tested or validated in humans. In this study, we tested 21 wt% lignin-containing nanocellulose (L-MFC) in vitro using the human lung and kidney cell lines, H460 and HEK293 cells, respectively. The cytotoxicity of cellulose, L-MFC, and lignin was compared using the water-soluble tetrazolium salt assays. In addition, the gene expressions of HSP70 and HSP90 as cellular stress markers treated with cellulose, L-MFC, and lignin were quantified using real-time polymerase chain reaction (PCR) and Western blotting. Our data indicated little cytotoxicity for cellulose and significant cytotoxicity for lignin and a relatively low level of cytotoxicity for L-MFC, providing the lethal median concentration (LC50) values of L-MFC and lignin. The gene expression of HSP70 and HSP90 was little affected by moderate concentrations of L-MFC. Interestingly, the lignin contained in L-MFC influenced the cell viability and the gene expression of HSP70 and HSP90 less than the same amount of lignin alone. These results indicate that L-MFC displays cell-type-dependent sensitivity and suggest that L-MFC could serve as a new eco-friendly material that is relatively safe for humans.

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“…Although some drugs have been determined to be nontoxic in traditional toxicity tests, they are reported to have a certain “biological effect”. Therefore, some researchers believe that it is necessary to consider a new concept of toxicity, namely, “epigenetic toxicity” [ 103 , 104 ]. Chemical compounds are anticipated to be able to be classified as epigenetic carcinogens based on mechanistic evidence [ 105 ].…”

Section: Application Of the Epigenetic Effect Of Antiepileptic Drugsmentioning

confidence: 99%

Epigenetic Effects Mediated by Antiepileptic Drugs and their Potential Application

Kong

Zhong

2020

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An epigenetic effect mainly refers to a heritable modulation in gene expression in the short term but does not involve alterations in the DNA itself. Epigenetic molecular mechanisms include DNA methylation, histone modification, and untranslated RNA regulation. Antiepileptic drugs have drawn attention to biological and translational medicine because their impact on epigenetic mechanisms will lead to the identification of novel biomarkers and possible therapeutic strategies for the prevention and treatment of various diseases ranging from neuropsychological disorders to cancers and other chronic conditions. However, these transcriptional and posttranscriptional alterations can also result in adverse reactions and toxicity in vitro and in vivo. Hence, in this review, we focus on recent findings showing epigenetic processes mediated by antiepileptic drugs to elucidate their application in medical experiments and shed light on epigenetic research for medicinal purposes.

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Epigenetic toxicity of environmental chemicals upon exposure during development - Bisphenol A and valproic acid may have epigenetic effects

Cited by 24 publications

References 21 publications

Tissue- and Sex-Specific DNA Methylation Changes in Mice Perinatally Exposed to Lead (Pb)

Tissue- and Sex-Specific DNA Methylation Changes in Mice Perinatally Exposed to Lead (Pb)

In Vitro Evaluation of Lignin-Containing Nanocellulose

Epigenetic Effects Mediated by Antiepileptic Drugs and their Potential Application

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