An examination of components of recovery after five years of treatment in an early intervention program for psychosis

Norman, Ross; MacDougall, Arlene; Manchanda, Rahul; Harricharan, Raj

doi:10.1016/j.schres.2017.08.054

Cited by 14 publications

(10 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A total of 47 studies (Addington et al, 2012;Addington & Addington, 2008;Addington, Leriger, et al, 2003;Addington, Young, et al, 2003;Alem et al, 2009;Arceo & Ulloa,2019;Bachmann et al, 2007;Bodén et al, 2014;Carter et al, 2011;Češková et al,2007Chan et al, 2015Chan et al, , 2019Chang et al, 2014;Chua et al, 2019;Economou et al, 2011;Giraud-Baro et al, 2016;Hassan & Taha, 2011;Heering et al, 2015;Hegelstad et al, 2012;Jaracz et al, 2015;Johansson et al, 2018;Johnson et al, Malla et al, 2002;Mattsson et al, 2008;Norman et al, 2014Norman et al, , 2018Revier et al, 2015;Ritsner et al, 2014;Ruggeri et al, 2004;Saravanan et al, 2010;Schennach et al, 2020;Segarra et al, 2012;Shibre et al, 2015;Singh et al, 2007;Spellmann et al, 2012;Strålin et al, October 2018;Suresh et al, 2012;Torgalsbøen et al, 2014;Üçok et al, 2011;Verdoux et al, 2010;Verma et al, 2012;Whitty et al, 2008;…”

Section: Re Sultsmentioning

confidence: 99%

Schizophrenia outcomes in the 21st century: A systematic review

et al. 2021

View full text Add to dashboard Cite

show abstract

Section: Re Sultsmentioning

confidence: 99%

Schizophrenia outcomes in the 21st century: A systematic review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…For patients with schizophrenia, the probability of functional recovery is highest at the early stages of the illness, around the time of the first psychotic episode [1][2][3] ; when a chronic pattern of the illness gets established, the chances of functional recovery greatly diminish, with only a small sub-group (~13%) recovering at this stage 4,5 . Currently, we do not know what mechanistic processes underlie these diminishing returns in recovery rates over time.…”

Section: Introductionmentioning

confidence: 99%

Central oxidative stress and early vocational outcomes in first episode psychosis: A 7-Tesla Magnetic Resonance Spectroscopy study of glutathione

Mackinley

Ford²,

Jeon

et al. 2021

Preprint

View full text Add to dashboard Cite

Following the first episode of psychosis, some patients develop poor social and occupational outcomes, while others display a pattern of preserved functioning. Several lines of evidence from preclinical, genetic and biochemical studies suggest a role for high oxidative stress in poor functional outcomes. The measurement of intracortical glutathione (GSH) using magnetic resonance spectroscopy (MRS) provides an opportunity to investigate the relationship between central antioxidant tone and functional outcomes at the time of first episode psychosis (FEP). A body of epidemiological studies indicates better functional outcomes in patients at early stages of schizophrenia compared to patients at a chronic, established phase of illness. We scanned 57 patients with FEP and 30 matched healthy controls and estimated GSH resonance using 7-Tesla MRS. We minimised the confounding effects of illness chronicity, long-term treatment exposure and metabolic complications by recruiting patients with <2 weeks of lifetime antipsychotic exposure on average and followed up this cohort for the next 1 year to determine functional outcomes. Patients with FEP who achieved employment/education or training status (EET) in the first year, had higher GSH at the baseline than healthy controls. Social and occupational functioning assessment scale (SOFAS) scores were also significantly higher in patients with higher GSH levels at the outset, after adjusting for various confounds including baseline SOFAS. Patients who were not in employment, education or training (NEET) did not differ from healthy subjects in their GSH levels. Our observations support a key role for the central antioxidant tone in the functional outcomes of early psychosis.

show abstract

“…Schizophrenia is one of the most devastating of adolescent onset illnesses. Despite the advances in pharmacological, psychological and social aspects of care in the last 50 years, only a small sub-group achieves combined clinical and functional recovery (~13%) [1,2]. Over several decades, barely any improvement has occurred in life expectancy and the years of potential life lost [3].…”

Section: Introductionmentioning

confidence: 99%

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Palaniyappan¹,

Park²,

Jeon³

et al. 2021

Preprint

View full text Add to dashboard Cite

Schizophrenia continues to be an illness with poor outcome. Most mechanistic changes occur many years before the first episode of schizophrenia; these are not reversible after the illness onset. A developmental mechanism that is still modifiable in adult life may center on intracortical glutathione (GSH). A large body of pre-clinical data has suggested the possibility of notable GSH-deficit in a subgroup of patients with schizophrenia. Nevertheless, studies of intracortical GSH are not conclusive in this regard. In this review, we highlight the recent ultra-high field magnetic resonance spectroscopic studies linking GSH to critical outcome measures across various stages of schizophrenia. We discuss the methodological steps required to conclusively establish or refute the persistence of GSH-deficit subtype and clarify the role of the central antioxidant system in disrupting the brain structure and connectivity in the early stages of schizophrenia. We propose in-vivo GSH quantification for patient selection in forthcoming antioxidant trials in psychosis. This review offers directions for a promising non-dopaminergic early intervention approach in schizophrenia.

show abstract

An examination of components of recovery after five years of treatment in an early intervention program for psychosis

Cited by 14 publications

References 42 publications

Schizophrenia outcomes in the 21st century: A systematic review

Schizophrenia outcomes in the 21st century: A systematic review

Central oxidative stress and early vocational outcomes in first episode psychosis: A 7-Tesla Magnetic Resonance Spectroscopy study of glutathione

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Contact Info

Product

Resources

About