Distinct pattern of immune tolerance in dendritic cells treated with lipopolysaccharide or lipoteichoic acid

Yoon, Hye-Kyung; Kim, Girak; Ju, Youngjun; Cheon, In Su; Hong, Seong Hyeon; Kim, Dong Wook; Park, Byung‐Chul; Han, Seung Hyun; Yun, Cheol‐Heui

doi:10.1016/j.molimm.2017.08.023

Cited by 9 publications

(5 citation statements)

References 34 publications

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“…However, the ratio between the anti-inflammatory cytokine IL-10 and the pro-inflammatory cytokine TNF-α was higher in LTA (50 µg/mL) than in LPS (47 vs. 1207, respectively), showing a certain degree of bias towards a regulatory or anti-inflammatory activity. Even though LTA isolated from other bacterial sources induced IL-12 secretion by BMDC [ 9 , 16 , 17 ], LTA from LGG was unable to upregulate neither IL-12p70 nor IL-12p40 secretion in our working conditions (data not shown). Thus, these results demonstrate that LTA is capable of activating BMDC by inducing both MHC-II and CD86 expression as well as cytokine release.…”

Section: Resultsmentioning

confidence: 78%

Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG Modulates Dendritic Cells and T Cells in the Gut

et al. 2022

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Lipoteichoic acid (LTA) from Gram-positive bacteria exerts different immune effects depending on the bacterial source from which it is isolated. Lacticaseibacillus rhamnosus GG LTA (LGG-LTA) oral administration reduces UVB-induced immunosuppression and skin tumor development in mice. In the present work, we evaluate the immunomodulatory effect exerted by LGG-LTA in dendritic cells (DC) and T cells, both in vitro and in the gut-associated lymphoid tissue (GALT). During cell culture, LTA-stimulated BMDC increased CD86 and MHC-II expression and secreted low levels of pro and anti-inflammatory cytokines. Moreover, LTA-treated BMDC increased T cell priming capacity, promoting the secretion of IL-17A. On the other hand, in orally LTA-treated mice, a decrease in mature DC (lamina propria and Peyer’s patches) was observed. Concomitantly, an increase in IL-12p35 and IFN-γ transcription was presented (lamina propria and Peyer’s Patches). Finally, an increase in the number of CD103+ DC was observed in Peyer’s patches. Together, our data demonstrate that LGG-LTA activates DC and T cells. Moreover, we show that a Th1-biased immune response is triggered in vivo after oral LTA administration. These effects justify the oral LTA activity previously observed.

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Section: Resultsmentioning

confidence: 78%

Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG Modulates Dendritic Cells and T Cells in the Gut

et al. 2022

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“…We have also showed that recombinant proteins from SARS-CoV-2 induced both HIF1a and IRAK-M overexpression on human monocytes. Note that these molecules are responsible for the ET phenotype (13,22,24,41,42). This fact suggests that HIF1a pathway and its associated IRAK-M overexpression could be the main actors in the tolerant immune signs observed in COVID-19 monocytes.…”

Section: Discussionmentioning

confidence: 97%

SARS-CoV-2 Proteins Induce Endotoxin Tolerance Hallmarks: A Demonstration in Patients with COVID-19

Avendaño-Ortíz

Lozano-Rodríguez

Martín-Quirós

et al. 2021

The Journal of Immunology

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According to a large number of reported cohorts, sepsis has been observed in nearly all deceased patients with COVID-19. We and others have described sepsis, among other pathologies, to be an endotoxin tolerance (ET)related disease. In this study, we demonstrate that the culture of human blood cells from healthy volunteers in the presence of SARS-CoV-2 proteins induced ET hallmarks, including impairment of proinflammatory cytokine production, low MHC class II (HLA-DR) expression, poor T cell proliferation, and enhancing of both phagocytosis and tissue remodeling. Moreover, we report the presence of SARS-CoV-2 blood circulating proteins in patients with COVID-19 and how these levels correlate with an ET status, the viral RNA presence of SARS-CoV-2 in plasma, as well as with an increase in the proportion of patients with secondary infections.

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“…DC isolated from mice spleen showed suppressive phenotypes after being introduced with lipopolysaccharide (LPS) or lipoteichoic acid (LTA). 12 Other studies have shown that semi-mature DC of SLE patients incubated with a combination of vitamin D3 and dexamethasone, then matured with LPS, elicits a better tolerogenic response compared to immature DC. 13 Recently, there is also strong evidence showing that mature DC can induce tolerogenic response by inducing Foxp3+ T reg.…”

Section: Discussionmentioning

confidence: 99%

Significant improvement of systemic lupus erythematosus manifestation in children after autologous dendritic cell transfer: a case report and review of literature

Jonny,

Putranto,

Purnama

et al. 2023

Therapeutic Advances in Vaccines and Immunotherapy

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Dendritic cells (DC) are postulated to play a role in autoimmune diseases such as Systemic Lupus Erythematosus (SLE). We reported a 13-year-old female SLE patient who presents with chronic arthritis accompanied by persistent fever, dyspnea, sleep disturbance, headache, stomatitis, rash, and muscle weakness. The supporting examinations showed abnormal blood cell counts, positive antinuclear antibody profile, serositis, and neuropathy. Immunosuppressants failed to improve the condition. DC-based vaccine derived from autologous peripheral blood which was introduced with SARS-CoV-2 protein was given to this patient. There was a significant improvement in clinical and laboratory findings. Thus, DC immunotherapy appears to be a potential novel therapy for SLE that needs to be studied.

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Distinct pattern of immune tolerance in dendritic cells treated with lipopolysaccharide or lipoteichoic acid

Cited by 9 publications

References 34 publications

Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG Modulates Dendritic Cells and T Cells in the Gut

Lipoteichoic Acid from Lacticaseibacillus rhamnosus GG Modulates Dendritic Cells and T Cells in the Gut

SARS-CoV-2 Proteins Induce Endotoxin Tolerance Hallmarks: A Demonstration in Patients with COVID-19

Significant improvement of systemic lupus erythematosus manifestation in children after autologous dendritic cell transfer: a case report and review of literature

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