Association between objective signs and subjective symptoms of dry eye disease in patients with systemic sclerosis

Rentka, Anikó; Nagy, Annamária; Hársfalvi, Jolán; Szűcs, Gabriella; Szekanecz, Zoltán; Gesztelyi, Rudolf; Szodoray, Péter; Kemény-Beke, Ádám

doi:10.1007/s00296-017-3794-2

Cited by 22 publications

(28 citation statements)

References 29 publications

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“…44 In examining objective signs and subjective symptoms of DED in SSc patients, the authors of another study found a positive correlation between subjective symptoms and disease duration. 45 In our study, a significant association was detected between NFC data and both tear film stability and subjective symptoms of DED. Because some NFC attributes are relevant to DED, these findings require further investigation to determine whether NFC is an applicable supplementary diagnostic tool for DED.…”

Section: Dedsupporting

confidence: 55%

A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis

Szűcs

Szekanecz

Aszalos

et al. 2019

Ocular Immunology and Inflammation

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Objectives: Systemic sclerosis (SSc) is a rare, chronic connective tissue disease involving multiple organ systems, including the eye. We evaluated the detailed clinical ocular manifestations of outpatients with SSc. Methods: Demographics, disease duration and subtype, nailfold capillaroscopy (NFC) patterns and laboratory parameters encompassing the autoantibody profile of 51 SSc patients were evaluated, and a general ocular examination was performed for each participant. Results: Twenty-nine patients (56.86%) had eyelid skin alterations, 26 (50.98%) had retinal abnormalities, 26 (50.98%) had cataracts, 8 (15.69%) had conjunctival changes, 7 (13.73%) had iris abnormalities, 33 (64.71%) suffered from dry eye disease (DED), and 11 (21.57%) suffered from glaucoma. Significant positive correlations were found between NFC data and both tear breakup time and Ocular Surface Disease Index test values. Conclusions: Eyelid skin abnormalities, DED and retinal abnormalities are among the most common SSc-related ocular involvements. Diverse ophthalmic findings are attributed to the heterogeneity of SSc.

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Section: Dedsupporting

confidence: 55%

A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis

Szűcs

Szekanecz

Aszalos

et al. 2019

Ocular Immunology and Inflammation

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“…DED can be assessed based on a combination of symptoms and signs. However, several studies reported poor correlation between DED symptoms and signs [26][27][28]. Dryness symptoms could be assessed systematically using validated questionnaires that include questions allow for the monitoring of dryness symptoms and their frequency and or their severity over time [29].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and associated risk factors of dry eye disease in 16 northern West bank towns in Palestine: a cross-sectional study

et al. 2020

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Background: Dry Eye Disease (DED) is a multifactorial disease of the interpalpebral ocular surface and tear film that leads to discomfort, fatigue and disturbance in vision. DED affects patients' quality of life and leads eventually to decrease of productivity. Moreover, it has a considerable socioeconomic burden. It is a growing underdiagnosed health issue and the possible associated risk factors are very common and keep growing worldwide. Purpose: To assess the prevalence of DED and potential associated risk factors in the Northern West Bank of Palestine. Methods: A cross sectional study was conducted in 16 selected towns in Northern West Bank governorates during December 2016 to September 2017. An interviewer-assisted Ocular Surface Disease Index (OSDI) questionnaire was used to study DED symptoms in the study population. Further evaluation of clinical signs of DED was performed using the following objective tests: tear film break-up time (TBUT), fluorescein corneal staining (FL/S) and Schirmer test. Subjects with an OSDI score of 13 or above were considered symptomatic of DED, and DED was defined if an OSDI score ≥ 13 is accompanied by at least one of the following signs in the worse eye: TBUT ≤10 s, Schirmer score ≤ 5 mm and fluorescein corneal staining ≥ grade 1. Results: Seven hundred sixty-nine subjects were recruited from the general non-clinical population in the West Bank. The mean age of participants was 43.61 ± 18.57 years ranging from 18 to 90 years. Females constitute 52.7% of the study population. Based on the diagnostic criteria, the prevalence of DED was 64% (95% confidence interval 60.6-67.3). DED was significantly associated with female gender p = (0.001) and older age p = (0.001). Conclusion: The prevalence of DED is high in the study population. Older age and female gender were associated risk factors with the development of DED.

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“…At the following stage the skin becomes shiny, taut and adherent to the subcutis [14]. Rentka et al [17] found a significant correlation between the OSDI question-Open Access Library Journal naire and the duration of SSc. The data obtained in our study showed a good correlation between the OSDI and SANDE questionnaires, evidencing that both can be used to support the diagnosis of dry eye in SSc patients.…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic Findings in Systemic Sclerosis and Its Association with Dermal Fibrosis

Villegas¹,

Yáñez²

2019

OALib

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Objective: To determine frequency and type of ophthalmologic findings in Systemic Sclerosis (SSc) and to establish their association with the extent and severity of cutaneous fibrosis. Methods: Descriptive-transversal study of 34 patients, (January-December 2017). It included patients with limited cutaneous Systemic Sclerosis (lcSS) and diffuse cutaneous Systemic Sclerosis (dcSS). The severity of cutaneous fibrosis was measured using the modified Rodnan skin score (mRSS). The ophthalmologic examination consisted of the evaluation of the palpebral fibrosis and the ocular surface by Schirmer's test, tear rupture time (BUT), OSDI (Ocular Disease Surface Index) and SANDE (Symptom Assessment in Dry Eye) questionnaires, eye fundus and retinography. We use simple logistic regression (OR) to establish the association with p < 0.05. Results: 21 patients (61.7%) with dcSS and 13 patients (38.2%) with lcSS. Women 32 (94.1%). Mean disease time 67.4 months. The mRSS was mild in 10 (29.4%) and moderate-severe in 24 (70.6%). The main findings: palpebral fibrosis 30 (88.2%), keratoconjunctivitis sicca (KCS) 26 (76.5%), blepharophimosis 20 (58.8%) and enophthalmos 7 (20.6%) had alteration of the retinal pigment epithelium 3 (8.8%). Associated with the extension: blepharophimosis, enophthalmos and KCS predominated in dcSS with Schirmer test positive in 52.4%, mild dry eye highlighted in both groups. We found significant association between blepharophimosis and moderate-severe mRSS. Conclusion: Eyelids skin thickening and KCS were more prevalent in dcSS. Moderate-severe mRSS was associated with atrophic changes in the eyelids.

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Association between objective signs and subjective symptoms of dry eye disease in patients with systemic sclerosis

Cited by 22 publications

References 29 publications

A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis

A Wide Spectrum of Ocular Manifestations Signify Patients with Systemic Sclerosis

Prevalence and associated risk factors of dry eye disease in 16 northern West bank towns in Palestine: a cross-sectional study

Ophthalmic Findings in Systemic Sclerosis and Its Association with Dermal Fibrosis

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