Impact of maternal obesity on the incidence of pregnancy complications in France and Canada

Fuchs, Florent; Sénat, Marie-Victoire; Rey, Évelyne; Balayla, Jacques; Chaillet, Nils; Bouyer, Jean; Audibert, François

doi:10.1038/s41598-017-11432-5

Cited by 41 publications

(34 citation statements)

References 18 publications

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“…O affects over a third of women of reproductive age in the US [24]. Pre-pregnancy O is seen in nearly 25% of gravid women in the US [25] and 17% of those in Canada [26,27]. A metaanalysis of 1 095 834 women found no overall increased risk of PTB in overweight and obese women (RR 1.06; 95% CI 0.87 to 1.30), but a heightened risk of piPTB (RR 1.30; 95%CI 1.23 to 1.37) [28].…”

Section: Discussionmentioning

confidence: 99%

Impact of diabetes, obesity and hypertension on preterm birth: Population-based study

et al. 2020

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Objective To determine the impact of pre-pregnancy diabetes mellitus (D), obesity (O) and chronic hypertension (H) on preterm birth (PTB). Methods Retrospective population-based cohort study in Ontario, Canada between 2012-2016. Women who had a singleton livebirth or stillbirth at > 20 weeks gestation were included in the cohort. Exposures of interest were D, O and H, individually, and in various combinations. The primary outcome was PTB at 24 1/7 to 36 6/7 weeks. PTB was further analyzed by spontaneous or provider-initiated, early (< 34 weeks) or late (34-37 weeks), and the co-presence of preeclampsia, large for gestational age (LGA), and small for gestational age (SGA). Multivariable Poisson regression models with robust error variance were used to generate relative risks (RR), further adjusted for maternal age and parity (aRR). Population attributable fractions (PAF) were calculated for each of the outcomes by exposure state. Results 506,483 women were eligible for analysis. 30,139 pregnancies (6.0%) were complicated by PTB < 37 weeks, of which 7375 (24.5%) had D or O or H. Relative to women without D or O or H, the aRR for PTB < 37 weeks was higher for D (3.51; 95% CI 3.26-3.78) and H (3.81; 95% CI 3.55-4.10) than O (1.14; 95% CI 1.10-1.17). The combined state of DH was associated with a significantly higher aRR of PTB < 37 weeks (6.34; 95% CI 5.14-7.80) and < 34 weeks (aRR 10.33, 95% CI 6.96-15.33) than D alone. The risk of provider initiated PTB was generally higher than that for spontaneous PTB. Pre-pregnancy hypertension was

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Section: Discussionmentioning

confidence: 99%

Impact of diabetes, obesity and hypertension on preterm birth: Population-based study

et al. 2020

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“…A gradient of risk exists for the incidence of gestational diabetes (GDM) [4], pre-eclampsia [5] and large for gestational age (LGA) infants [6], as obesity severity increases in pregnancy. Furthermore, gestational weight gain (GWG) is an additional risk factor for pregnancy complications, demonstrating strong associations with LGA and macrosomic infants [7].…”

Section: Introductionmentioning

confidence: 99%

The UK Pregnancies Better Eating and Activity Trial (UPBEAT); Pregnancy Outcomes and Health Behaviours by Obesity Class

Peacock

Seed

Dalrymple

et al. 2020

IJERPH

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The effectiveness of antenatal intervention in women with increasing obesity is unknown. This study investigated whether there was a differential effect of antenatal intervention on diet, physical activity and pregnancy outcomes in women stratified by obesity class using data from the UK Pregnancies Better Eating and Activity Trial (UPBEAT) (n = 1555). The stratification was by World Health Organization classifications: Class I, II and III (30–34.9 kg/m2, 35–39.9 kg/m2 and ≥40 kg/m2). Using linear and logistic regression, adjusted for confounders, outcomes were assessed post-intervention (27+0–28+6 weeks’ gestation) and in late pregnancy (34+0–36+0 weeks’ gestation). Interactions between obesity class and the intervention were explored. Compared to the standard care arm, class III intervention women had lower gestational weight gain (GWG) (−1.87 kg; 95% CI −3.29 to −0.47, p = 0.009), and the effect of the intervention was greater in class III compared to class I, by −2.01 kg (95% CI −3.45 to −0.57, p = 0.006). Class I and II intervention women reported significantly lower dietary glycaemic load and saturated fat intake across their pregnancy. This differential effect of the intervention suggests antenatal interventions for women with obesity should stratify outcomes by obesity severity. This would inform evidence-based antenatal strategies for high-risk groups, including women with a BMI ≥ 40 kg/m2.

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“…Elevated maternal pre-pregnancy BMI can lead to a higher risk of maternal and fetal morbidities and mortality [7][8][9][10][11][12][13]. It is controversial whether or not obesity impacts the response to assisted reproductive technology (ART) treatments [14][15][16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Does body mass index impact assisted reproductive technology treatment outcomes in gestational carriers

Weizman

Defer

Montbriand

et al. 2020

Reprod Biol Endocrinol

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Background: The purpose of this study was to assess whether increased body mass index (BMI) negatively affects assisted reproductive technology (ART) outcomes among gestational carriers. Methods: A retrospective matched case-control cohort, including all gestational carrier (GC) cycles performed at CReATe Fertility Centre (Toronto, ON, Canada) between 2003 and 2016. Setting: A Canadian fertility clinic, with a large surrogacy program. Patients: All gestational carriers that had undergone a cycle completed to a transfer at our clinic, and had BMI and outcome data available, were matched by BMI to infertile patients treated at our clinic during the same years provided they had undergone a cycle completed to a transfer, and had outcomes data available. Interventions: None. Main outcome measures: Clinical pregnancies rates, miscarriage rates and live birth rates. Results: BMI was not a reliable prediction factor of any of the measured outcomes. Importantly, the gestational carrier population had better outcomes and a significantly lower overall incidence of maternal, fetal and neonatal complications when compared with infertile patients, treated at our clinic during the same years. Conclusion: BMI is not a reliable predictor of outcomes among gestational carriers.

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Impact of maternal obesity on the incidence of pregnancy complications in France and Canada

Cited by 41 publications

References 18 publications

Impact of diabetes, obesity and hypertension on preterm birth: Population-based study

Impact of diabetes, obesity and hypertension on preterm birth: Population-based study

The UK Pregnancies Better Eating and Activity Trial (UPBEAT); Pregnancy Outcomes and Health Behaviours by Obesity Class

Does body mass index impact assisted reproductive technology treatment outcomes in gestational carriers

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