Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction

Akbar, Naveed; Digby, Janet E.; Cahill, Thomas J.; Tavare, Aniket; Corbin, Alastair; Saluja, Sonia; Dawkins, Sam; Edgar, Laurienne; Rawlings, Nadiia; Žiberna, Klemen; McNeill, Eileen; Johnson, Errin; Aljabali, Alaa A. A.; Dragovic, Rebecca; Rohling, Mala; Belgard, T. Grant; Udalova, Irina A.; Greaves, David R.; Channon, Keith M.; Riley, Paul R.; Anthony, Daniel C.; Choudhury, R P

doi:10.1172/jci.insight.93344

Cited by 93 publications

(111 citation statements)

References 68 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Following acute myocardial infarction, large numbers splenic monocytes mobilize to the damaged myocardium. Recent evidence suggests a role for endothelial-derived EVs in the initial monocytic recruitment [11*]. The total number of circulating EVs increases in plasma following myocardial infarction in both mice and humans, and the elevated number of EVs exhibit protein markers that suggest an endothelial cell origin.…”

Section: Extracellular Vesicles As Mediators Of Intracellular Communimentioning

confidence: 99%

Extracellular vesicles in cardiovascular homeostasis and disease

Hutcheson

Aikawa

2018

Current Opinion in Cardiology

View full text Add to dashboard Cite

Purpose of review Extracellular vesicles (EVs) have emerged as one of the most important means through which cells interact with each other and the extracellular environment, but EV research remains challenging due to their small size and limited amount of material required for traditional molecular biology assays. The advent of new technologies and standards in the field, however, have led to increased mechanistic insight into EV function. Herein, the latest studies on the role of EVs in cardiovascular physiology and pathology are discussed. Recent findings EVs help control cardiovascular homeostasis and remodeling by mediating communication between cells and directing alterations in the extracellular matrix to respond to changes in the environment. The message carried from the parent cell to extracellular space can be intended for both local (within the same tissue) and distal (downstream of blood flow) targets. Pathological cargo loaded within EVs could further result in various diseases. On the other hand, new studies indicate that injection of EVs obtained from cultured cells into diseased tissues can promote restoration of normal tissue function. Summary EVs are an integral part of cell and tissue function, and harnessing the properties inherent to EVs may provide a therapeutic strategy to promote tissue regeneration.

show abstract

Section: Extracellular Vesicles As Mediators Of Intracellular Communimentioning

confidence: 99%

Extracellular vesicles in cardiovascular homeostasis and disease

Hutcheson

Aikawa

2018

Current Opinion in Cardiology

View full text Add to dashboard Cite

show abstract

“…Cardiac failure will occur with reduced heart output and contractility. Cardiac arrhythmia may also follow when the cardiac septum is affected 83,84 .…”

Section: Trem-1 In Pathogenesis Of Atherosclerosismentioning

confidence: 99%

TREM-1; is It a Pivotal Target for Cardiovascular Diseases?

Kouassi

Gunasekar

Agrawal

et al. 2018

Preprint

View full text Add to dashboard Cite

Cardiovascular Diseases (CVDs) are still menacing and killing adults worldwide, notwithstanding the tremendous effort, to decrease their related mortality and morbidity. Lately, a growing body of evidences indicated that inflammation plays a pivotal role in the pathogenesis and complications of CVDs. A receptor of the immunoglobulin superfamily, triggering receptor expressed on myeloid cells -1 (TREM-1) was shown to induce and to amplify the inflammation in both acute and chronic diseases pathogenesis and progression and hence it is one of the important factors that complicates CVDs. Thus, studies endeavored to investigate the role played by TREM-1 in CVDs with respect to their etiologies, complications and possible therapeutics. We examined here, for the first time, the most relevant studies regarding TREM-1 involvement in CVDs. We summarized the finding after critically analyzing them and made some suggestions for furtherance of the investigations with the aim to utilize TREM-1 and its pathways for diagnostic, management and prognosis of CVDs. Overall, TREM-1 was found to be involved in the pathogenesis of acute and chronic cardiovascular conditions like Acute myocardial infraction (AMI) and atherosclerosis as well. Although most therapeutic approaches are yet to be elucidated, present research outcome displays a promising future to utilize TREM-1 pathway as potential target to understand and manage CVDs.

show abstract

“…Circulating microparticles have also been shown to play a significant role in the pathogenesis of atherosclerosis [34]. These vesicular bodies derived from platelets, monocytes and red blood cells are important in cell-to-cell signalling especially in context of inflammation [40]. More importantly, characterising these particles according to their content of protein, mRNA and miRNA, has also been significant in the function of cellular adhesions molecules, such as VCAM, and activation of macrophages within atherosclerotic plaque [34,41].…”

Section: The Inflammatory Cellular Component Of Atherosclerosismentioning

confidence: 99%

Current concepts in atherosclerosis

Alkhalil

Choudhury

2018

Indian J Thorac Cardiovasc Surg

Self Cite

View full text Add to dashboard Cite

Atherosclerosis is a complex disease process. It is increasingly recognised that both lipoprotein retention and inflammatory cellular components are intricately related in the initiation and development of atherosclerotic plaque. LDL-c (cholesterol) has been long established as a cause for atherosclerosis; additionally, inflammatory cells such as monocytes and subsequently foam cells have also been directly linked to the progression of atherosclerotic disease. Emerging data suggest that structures outside vascular intima and media are also closely related to atherosclerosis. Perivascular adipose tissue (PVAT) may be a determinant of the inflammatory status of the atherosclerotic plaque. All these features are becoming extremely relevant as therapies against atherosclerosis are targeting both lipid retention and inflammation. Recently, there has been some success in these novel therapies, such as the proprotein convertase subtilisin-kexin type 9 (PCSK-9) inhibitor evolocumab and the interleukin-1ß neutralising antibody, canakinumab, in reducing cardiovascular events when added to standard therapy such as statin. This review will discuss the pathogenesis of atherosclerosis, including some novel features, and its management using new anti-atherosclerotic drugs.

show abstract

Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction

Cited by 93 publications

References 68 publications

Extracellular vesicles in cardiovascular homeostasis and disease

Extracellular vesicles in cardiovascular homeostasis and disease

TREM-1; is It a Pivotal Target for Cardiovascular Diseases?

Current concepts in atherosclerosis

Contact Info

Product

Resources

About