Preparation of spherical metal–organic frameworks encapsulating ag nanoparticles and study on its antibacterial activity

Guo, Xin; Guo, Bin; Wang, Yuanlin; Guan, Shan

doi:10.1016/j.msec.2017.07.027

Cited by 58 publications

(25 citation statements)

References 48 publications

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“…The metallic nanoparticles, especially the silver (Ag) nanoparticles have been demonstrated to be effective antibacterial agents with broad antibacterial activity (Agarwal et al, 2010;Mahmoudi and Serpooshan, 2012;Neibert et al, 2012;Durmus and Webster, 2013;Mei et al, 2013;Shah et al, 2013;Agnihotri et al, 2015;Borrelli et al, 2015;Lim et al, 2015;Kyaw et al, 2017;Ximing et al, 2017;Kim et al, 2018;Liu et al, 2018Liu et al, , 2019Gasmalla et al, 2019;Zhang et al, 2019Zhang et al, , 2020He et al, 2020;Horue et al, 2020;Tong et al, 2020). Silver nanoparticles can increase the permeability of bacterial membrane and cell wall and, penetrate into the cytoplasm.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, the methotrexate (MTX) is also included in the nano-carrier to treat the inflammatory reaction associated with bacterial infection (Lebugle et al, 2002;Alam et al, 2017;Yang et al, 2017;Duan and Li, 2018;Trujillo-Nolasco et al, 2019;Sun et al, 2020). To address the aforementioned issues of bare silver nanoparticles, different nano-carriers have been constructed, such as metalorganic frameworks (MOFs) (Ximing et al, 2017;Zhang et al, 2019Zhang et al, , 2020, hybrid metallic nanoparticles (Mahmoudi and Serpooshan, 2012;Durmus and Webster, 2013;Mei et al, 2013;Shah et al, 2013;Agnihotri et al, 2015;Lim et al, 2015;Kyaw et al, 2017;Kim et al, 2018;Liu et al, 2018;Gasmalla et al, 2019;He et al, 2020;Tong et al, 2020) and mesoporous nanoparticles (Liu et al, 2019). However, the above nano-carriers have some drawbacks, for instance, the low drug loading capacity (<10%) (Cai et al, 2015) and the complexity of designing a multicomponent nano-carrier (containing at least the carrier and two or more compounds).…”

Section: Introductionmentioning

confidence: 99%

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The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy

et al. 2021

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The over-use of antibiotics has promoted multidrug resistance and decreased the efficacy of antibiotic therapy. Thus, it is still in great need to develop efficient treatment strategies to combat the bacteria infection. The antimicrobial photodynamic therapy (aPDT) and silver nanoparticles have been emerged as effective antibacterial methods. However, the silver therapy may induce serious damages to human cells at high concentrations and, the bare silver nanoparticles may rapidly aggregate, which would reduce the antibacterial efficacy. The encapsulation of sliver by nano-carrier is a promising way to avoid its aggregation and facilitates the co-delivery of drugs for combination therapy, which does not require high concentration of sliver to exert antibacterial efficacy. This work constructed a self-assembled supermolecular nano-carrier consisting of the photosensitizers (PSs), the anti-inflammatory agent and silver. The synthesized supermolecular nano-carrier produced reactive oxygen species (ROS) under the exposure of 620-nm laser. It exhibited satisfying biocompatibility in L02 cells. And, this nano-carrier showed excellent antibacterial efficacy in Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as indicated by bacterial growth and colony formation. Its antibacterial performance is further validated by the bacteria morphology through the scanning electron microscope (SEM), showing severely damaged structures of bacteria. To summary, the supermolecular nano-carrier TCPP-MTX-Ag-NP combining the therapeutic effects of ROS and silver may serve as a novel strategy of treatment for bacterial infection.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy

et al. 2021

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“…The inhibition rates on E. coli, Bacillus subtilis, S. aureus, and their mixed strains were 82.18, 72.8, 89.1, and 80.4%, respectively, which were significantly higher than positive control penicillin (Ximing et al, 2017). The bactericidal principle was that the silver nanoparticles encapsulated in MOFs contacted with oxygen to form Ag + , which destroyed cell membrane permeability and caused bacterial death (Ximing et al, 2017). Similar results about Ag nanoparticles-MOF as antibacterial hybrid could also be found in recent studies (Zhu et al, 2015;Thakare and Ramteke, 2017;Abd El Salam et al, 2018).…”

Section: Metal-organic Frameworkmentioning

confidence: 85%

“…Moreover, the multifunctional combination of MOFs with metal/metal oxides nanoparticles further improves their bactericidal capacities. Ximing et al (2017) successfully synthesized copper-based MOF (CuTCPP MOF) to encapsulate silver nanoparticles and prepared a new composite material Ag-CuTCPP MOF. The inhibition rates on E. coli, Bacillus subtilis, S. aureus, and their mixed strains were 82.18, 72.8, 89.1, and 80.4%, respectively, which were significantly higher than positive control penicillin (Ximing et al, 2017).…”

Section: Metal-organic Frameworkmentioning

confidence: 99%

“…Ximing et al (2017) successfully synthesized copper-based MOF (CuTCPP MOF) to encapsulate silver nanoparticles and prepared a new composite material Ag-CuTCPP MOF. The inhibition rates on E. coli, Bacillus subtilis, S. aureus, and their mixed strains were 82.18, 72.8, 89.1, and 80.4%, respectively, which were significantly higher than positive control penicillin (Ximing et al, 2017). The bactericidal principle was that the silver nanoparticles encapsulated in MOFs contacted with oxygen to form Ag + , which destroyed cell membrane permeability and caused bacterial death (Ximing et al, 2017).…”

Section: Metal-organic Frameworkmentioning

confidence: 99%

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Microporous Frameworks as Promising Platforms for Antibacterial Strategies Against Oral Diseases

Wan

Ren

et al. 2020

Front. Bioeng. Biotechnol.

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Nowadays, the heavy burden of oral diseases such as dental caries, periodontitis, endodontic infections, etc., and their consequences on the patients' quality of life indicate a strong need for developing effective therapies. Bacterial infections played an important role in the field of oral diseases, in-depth insight of such oral diseases have given rise to the demand for antibacterial therapeutic strategies. Recently, microporous frameworks have attracted tremendous interest in antibacterial application due to their well-defined porous structures for drug delivery. In addition, intensive efforts have been made to enhance the antibacterial performance of microporous frameworks, such as ion doping, photosensitizer incorporation as building blocks, and surface modifications. This review article aims on the major recent developments of microporous frameworks for antibacterial applications against oral diseases. The first part of this paper puts concentration on the cutting-edge researches on the versatile antibacterial strategies of microporous materials via drug delivery, inherent activity, and structural modification. The second part discusses the antibacterial applications of microporous frameworks against oral diseases. The applications of microporous frameworks not only have promising therapeutic potential to inhibit bacterial plaque-initiated oral infectious diseases, but also have a wide applicability to other biomedical applications.

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Introducing Metal–Organic Frameworks to Melt Electrowriting: Multifunctional Scaffolds with Controlled Microarchitecture for Tissue Engineering Applications

Mansi,

Dummert,

Topping

et al. 2023

Adv Funct Materials

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Scaffolds with multiple advantageous biological and structural properties are still a challenge in the field of tissue engineering. The convergence of advanced fabrication techniques and functional materials is key to fulfill this need. Melt electrowriting (MEW) is an additive manufacturing technique that enables the fabrication of microfibrous scaffolds with precisely defined microarchitectures. Here, it is proposed to exploit metal–organic frameworks (MOFs) to efficiently introduce multifunctionalities by combining polycaprolactone (PCL), the gold standard material in MEW, with a silver‐/silver‐chloride‐decorated iron‐based MOF (NH2‐MIL‐88B(Fe)). This results in highly ordered constructs with antibacterial properties and magnetic resonance imaging (MRI) visibility. Scaffolds with up to 20 wt% MOF are successfully melt‐electrowritten with a fiber diameter of 50 µm. Among these, 5 wt% MOF proves to be the optimal concentration as it exhibits silver‐induced sustained antibacterial efficacy while maintaining PCL cytocompatibility and in vitro immune response. The iron component of the MOF (Fe(III) nodes) renders the composite visible with MRI, thereby enabling scaffold monitoring upon implantation with a clinically accepted method. The combination of MEW and MOFs as tunable additives and cargo carriers opens the way for designing advanced multifunctional scaffolds with a wide range of applications in, e.g., tissue engineering, biosensing and drug delivery.

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Preparation of spherical metal–organic frameworks encapsulating ag nanoparticles and study on its antibacterial activity

Cited by 58 publications

References 48 publications

The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy

The Antibacterial Effects of Supermolecular Nano-Carriers by Combination of Silver and Photodynamic Therapy

Microporous Frameworks as Promising Platforms for Antibacterial Strategies Against Oral Diseases

Introducing Metal–Organic Frameworks to Melt Electrowriting: Multifunctional Scaffolds with Controlled Microarchitecture for Tissue Engineering Applications

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