SERS active self-assembled diphenylalanine micro/nanostructures: A combined experimental and theoretical investigation

Kogikoski, Sergio; Khanra, Soma; Alves, Wendel A.; Guha, S.

doi:10.1063/1.4990828

Cited by 10 publications

(6 citation statements)

References 51 publications

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“…Despite the fact that many substrate designs have been developed to increase Raman intensity, there are very few studies in the literature that have used FF-PNTs as a template to support SERS active substrates 49 – 51 . It has been previously reported that aligned FF-PNT templates formed with plasmon-active Ag NPs enabled SERS detection of molecules 49 , 50 .…”

Section: Introductionmentioning

confidence: 99%

Photo-induced surface-enhanced Raman spectroscopy from a diphenylalanine peptide nanotube-metal nanoparticle template

Almohammed

Zhang

Rodriguez

et al. 2018

Sci Rep

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UV irradiation of aligned diphenylalanine peptide nanotubes (FF-PNTs) decorated with plasmonic silver nanoparticles (Ag NPs) enables photo-induced surface-enhanced Raman spectroscopy. UV-induced charge transfer facilitates a chemical enhancement that provides up to a 10-fold increase in surface-enhanced Raman intensity and allows the detection of a wide range of small molecules and low Raman cross-section molecules at concentrations as low as 10–13 M. The aligned FF-PNT/Ag NP template further prevents photodegradation of the molecules under investigation. Our results demonstrate that FF-PNTs can be used as an alternative material to semiconductors such as titanium dioxide for photo-induced surface-enhanced Raman spectroscopy applications.

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Section: Introductionmentioning

confidence: 99%

Photo-induced surface-enhanced Raman spectroscopy from a diphenylalanine peptide nanotube-metal nanoparticle template

Almohammed

Zhang

Rodriguez

et al. 2018

Sci Rep

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“…Finally, the interest of FF nanostructures as potential surface-enhanced Raman spectroscopy (SERS) substrates for biosensing and biomedical applications was demonstrated via TEM, Raman, luminescence and DFT calculations [ 121 ]. At 150 °C, L,L–FF micro-nanostructures (FF-MNSs) are subjected to an irreversible phase transition from hexagonally packed (hex) micro-nanotubes to an orthorhombic (ort) structure.…”

Section: Physico-chemical Characterization Of Short Peptides and Their Assemblymentioning

confidence: 99%

Synthesis, Characterization and Evaluation of Peptide Nanostructures for Biomedical Applications

et al. 2021

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There is a challenging need for the development of new alternative nanostructures that can allow the coupling and/or encapsulation of therapeutic/diagnostic molecules while reducing their toxicity and improving their circulation and in-vivo targeting. Among the new materials using natural building blocks, peptides have attracted significant interest because of their simple structure, relative chemical and physical stability, diversity of sequences and forms, their easy functionalization with (bio)molecules and the possibility of synthesizing them in large quantities. A number of them have the ability to self-assemble into nanotubes, -spheres, -vesicles or -rods under mild conditions, which opens up new applications in biology and nanomedicine due to their intrinsic biocompatibility and biodegradability as well as their surface chemical reactivity via amino- and carboxyl groups. In order to obtain nanostructures suitable for biomedical applications, the structure, size, shape and surface chemistry of these nanoplatforms must be optimized. These properties depend directly on the nature and sequence of the amino acids that constitute them. It is therefore essential to control the order in which the amino acids are introduced during the synthesis of short peptide chains and to evaluate their in-vitro and in-vivo physico-chemical properties before testing them for biomedical applications. This review therefore focuses on the synthesis, functionalization and characterization of peptide sequences that can self-assemble to form nanostructures. The synthesis in batch or with new continuous flow and microflow techniques will be described and compared in terms of amino acids sequence, purification processes, functionalization or encapsulation of targeting ligands, imaging probes as well as therapeutic molecules. Their chemical and biological characterization will be presented to evaluate their purity, toxicity, biocompatibility and biodistribution, and some therapeutic properties in vitro and in vivo. Finally, their main applications in the biomedical field will be presented so as to highlight their importance and advantages over classical nanostructures.

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“…One of the strategies to combat biofouling is to design a surface that will resist bacterial adhesion . This includes hydrophobic and hydrophilic polymer‐based materials, zwitterionic compounds, and topographical modification of the surface .…”

Section: Introductionmentioning

confidence: 99%

The effect of end‐group substitution on surface self‐assembly of peptides

Dolid

Reches

2019

Journal of Peptide Science

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Biofouling, the undesirable accumulation of organisms onto surfaces, affects many areas including health, water, and energy. We previously designed a tripeptide that self‐assembles into a coating that prevents biofouling. The peptide comprises three amino acids: DOPA, which allows its adhesion to the surface, and two fluorinated phenylalanine residues that direct its self‐assembly into a coating and acquire it with antifouling properties. This short peptide has an ester group at its C‐terminus. To examine the importance of this end group for the self‐assembly and antifouling properties of the peptide, we synthesized and characterized tripeptides with different end groups (ester, amide, or carboxylic group). Our results indicate that different groups at the C‐terminus of the peptide can lead to a change in the peptide assembly on the surface and its adsorption process. However, this change only affects the antifouling properties of the coating toward Gram‐positive bacteria (Staphylococcus epidermidis), whereas Gram‐negative bacteria (Escherichia coli) are not affected.

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SERS active self-assembled diphenylalanine micro/nanostructures: A combined experimental and theoretical investigation

Cited by 10 publications

References 51 publications

Photo-induced surface-enhanced Raman spectroscopy from a diphenylalanine peptide nanotube-metal nanoparticle template

Photo-induced surface-enhanced Raman spectroscopy from a diphenylalanine peptide nanotube-metal nanoparticle template

Synthesis, Characterization and Evaluation of Peptide Nanostructures for Biomedical Applications

The effect of end‐group substitution on surface self‐assembly of peptides

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