Erectile dysfunction in the elderly male

Gökçe, Mehmet İlker; Yaman, Önder

doi:10.5152/tud.2017.70482

Cited by 17 publications

(4 citation statements)

References 51 publications

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“…6 Dyslipidemia, which causes endothelial dysfunction and in ammation, becomes more prevalent with increasing age in men. 7 Hypertension further accelerates the atherosclerotic process, leading to tissue hypoxia in end-organs. 8 Diabetes mellitus, another clinical condition associated with erectile dysfunction, is known to decrease anti-in ammatory cytokine adiponectin and circulating testosterone.…”

Section: Introductionmentioning

confidence: 99%

Can control of visceral adiposity index improve sexual function in men with metabolic syndrome?

Bolat,

Yılmaz,

Dündar

et al. 2024

Preprint

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The metabolic syndrome (MeTS) negatively affects male sexual function. Lifestyle changes improve erectile function. However, the effects of lifestyle changes on sexual function in men with and without MeTS on the visceral adiposity index (VAI) have not been adequately investigated. Patients with MeTS (n = 48) and those with no MeTS (n = 31) were recruited. Sexual functions and psychogenic status were assessed using the International Index of Erectile Dysfunction (IIEF) questionnaire and Beck’s depression inventory (BDI), respectively. The VAI was calculated using the gender-specific formula. Demographic, clinical, biochemical and hormonal data were recorded. Participants were advised to 8500 steps per day and dietary control. At least three months later, demographic and biochemical tests were repeated, and the VAI was calculated. Association between sexual functions, presence of MeTS and lifestyle changes via the VAI were analyzed. Each integer increase of the VAI was related to a 1.74-fold increased risk of ED in the MeTS group. The MeTS was related to moderate to severe ED than those with no MeTS (p = 0.033). A 24% decrease of the VAI was recorded in the MeTS group at the end of the study (p = 0.014). The MeTS criteria were disappeared in eight patients at the end of the study, with a slight decrease of VAI (p = 0.07). In the beginning, patients with MeTS and no-MeTS showed similar sexual satisfaction, orgasm, desire, and general satisfaction scores. Sexual satisfaction, orgasm and general satisfaction were improved in the non-MeTS group (p < 0.05). At the end of the study, the MeTS group showed similar sexual satisfaction, desire, orgasm and general satisfaction rates (p > 0.05). Higher VAI levels were related to the lower erectile function scores, particularly in patients with MeTS. Lifestyle changes improved male sexual function scores only in the non-MeTS group. Therefore, fighting against MeTS should be adopted as a global healthcare policy.

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Section: Introductionmentioning

confidence: 99%

Can control of visceral adiposity index improve sexual function in men with metabolic syndrome?

Bolat,

Yılmaz,

Dündar

et al. 2024

Preprint

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“…Тем не менее самым значимым фактором ЭД, реализуемым различными путями, явля-АНДРОЛОГИЯ 1 И ГЕНИТАЛЬНАЯ ХИРУРГИЯ ТОМ 24 / VOL. 24 2 0 2 3 ANDROLOGY AND GENITAL SURGERY Оригинальная статья / Original report ется возраст [6]. В связи с этим возникает практический вопрос: какова динамика морфологического строения основных артериальных сосудов полового члена -кавернозных артерий (КА) -у мужчин различного возраста?…”

Section: Introductionunclassified

Age dynamics of the morphological structure of the cavernous arteries in healthy men according to complex morphometric analysis

Strelkov¹,

Астраханцев²,

Snegur³

2023

Androl. genit. hir.

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Background. Erectile dysfunction is associated with systemic vascular diseases and, to a greater extent, with age, while there is insufficient data in the literature on the morphological state of the cavernous arteries (CA) in men of different ages in normal.Aim. A detailed morphometric assessment of the CA of men of various ages in the absence of signs of atherosclerosis and hypertension.Materials and methods. The material was transverse fragments of cavernous bodies with paired CA obtained during autopsy (58 observations, a total of 116 CA were examined). Hematoxylin and eosin, fuchsylin and picrofuxin, and Mallory staining were used. Detailed morphometric analysis was carried out according to the original method by measuring the perimeter and then calculating the area of the corresponding component of the vascular wall.Results. In the studied age range from 17 to 74 years, there was an increase in the total area of the CA from 0.76 mm2 in the age period of 17–21 years to 0.99 mm2 in the period of 36–60 years and a decrease to 0.43 mm2 at the age of 61–74 years. А similar increase in absolute indicators of the area of the lumen with a decrease in old age was revealed. The absolute area of intimacy and media, increasing by the age of 36–60 years, also significantly decreases in the age range of 61–74 years. At the same time, the relative area of intima to the vessel lumen has insignificant fluctuations, remaining a stable value in all age groups. The specific area of intima relative to the entire area of the vessel as a whole has a stable indicator, increasing in old age. The Kernogan Index tends to decrease throughout the studied age range from 33 to 26 %, which indicates the preservation of the spacecraft throughput in all the studied groups, including the elderly. This is also evidenced by the dynamics of the ratio of the diameter of the CA lumen to the thickness of the vessel wall, including intima and media, reaching maximum values of 4.15 by the period of 36–60 years, remaining at a high level of 3.53 and in the oldest age group. At the same time, the specific share of media significantly decreases in all groups of the studied age range of 17–74 years from 62.1 to 50.5 %. The ratio of the maximum lumen area of the vessel to the minimum as an indicator of the potential possibility of increasing the lumen of the spacecraft turned out to be maximum atthe ages of 17–21 years and 22–35 years,significantly decreasing in older age groupsfrom 176 to 130 %.Conclusion. Age-related remodeling of the spacecraft consistsin fairly stable morphometric parameters of the spacecraft in the age range from 17–21 years to a period of 36–60 years with a decrease at an older age, when a decrease in the absolute area of the lumen and the entire spacecraft isrevealed. A significant progressive decrease in the specific proportion of media and an increase in the proportion of intima in the structure of the vessel wall are shown. At the same time, up to the age of 36–60 years, spacecraft maintain their throughput indicators at a high level. Further studies of CA in vascular pathology may be useful in understanding the causes and mechanisms of the association of erectile dysfunction with the age of men.

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“…Of the changes observed in aging and implicated in the pathophysiology of ED we find: 1) Endothelial dysfunction, 2) Increased contractility and decreased vasodilation of the corpus cavernosum, 3) Oxidative stress, and 4) Increased vascular senescence [ 5 , 6 ]. Together, these processes lead to tissue remodeling and the development of ED [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

D-(+)-Galactose-induced aging: A novel experimental model of erectile dysfunction

et al. 2021

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Erectile dysfunction (ED) is defined as the inability to achieve and/or maintain penile erection sufficient for satisfactory sexual relations, and aging is one of the main risk factors involved. The D-(+)-Galactose aging model is a consolidated methodology for studies of cardiovascular aging; however, its potential for use with ED remain unexplored. The present study proposed to characterize a new experimental model for ED, using the D-(+)-Galactose aging model. For the experiments, the animals were randomly divided into three groups receiving: vehicle (CTL), D-galactose 150 mg/kg (DGAL), and D-(+)-galactose 150 mg/Kg + sildenafil 1.5 mg/Kg (DGAL+SD1.5) being administered daily for a period of eight weeks. All of the experimental protocols were previously approved by the Ethics Committee on the Use of Animals at the Federal University of Paraíba n° 9706070319. During the treatment, we analyzed physical, molecular, and physiological aspects related to the aging process and implicated in the development of ED. Our findings demonstrate for the first time that D-(+)-Galactose-induced aging represents a suitable experimental model for ED assessment. This was evidenced by an observed hyper-contractility in corpora cavernosa, significant endothelial dysfunction, increased ROS levels, an increase in cavernous tissue senescence, and the loss of essential penile erectile components.

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Erectile dysfunction in the elderly male

Cited by 17 publications

References 51 publications

Can control of visceral adiposity index improve sexual function in men with metabolic syndrome?

Can control of visceral adiposity index improve sexual function in men with metabolic syndrome?

Age dynamics of the morphological structure of the cavernous arteries in healthy men according to complex morphometric analysis

D-(+)-Galactose-induced aging: A novel experimental model of erectile dysfunction

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