Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma

Nishimoto, Koji; Karayama, Masato; Inui, Naoki; Mori, Kazutaka; Kono, Masato; Hozumi, Hironao; Suzuki, Yuzo; Furuhashi, Kazuki; Enomoto, Noriyuki; Fujisawa, Tomoyuki; Watanabe, Hiroshi; Suda, Takafumi

doi:10.1038/s41598-017-10504-w

Cited by 28 publications

(25 citation statements)

References 52 publications

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“…The detailed method of 3D-CT analysis of the airways has been described elsewhere 23,24,40 . In brief, multiple-detector-row CT (MDCT) imaging was performed using a 64-slice MDCT machine (Aquilion-64; Toshiba Medical Systems, Tokyo, Japan) in the supine position at full inspiration breath-hold.…”

Section: Methodsmentioning

confidence: 99%

Physiological and morphological differences of airways between COPD and asthma–COPD overlap

Karayama

Inui

Yasui

et al. 2019

Sci Rep

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Overlap of asthma and COPD has attracted attention recently. We aimed to clarify physiological and morphological differences of the airways between COPD and asthma–COPD overlap (ACO). Respiratory resistance and reactance and three-dimensional computed tomography data were evaluated in 167 patients with COPD. Among them, 43 patients who fulfilled the diagnosis of asthma were defined as having ACO. Among 124 patients with COPD without ACO, 86 with a comparable smoking history and airflow limitation as those with ACO were selected using propensity score matching (matched COPD). The intraluminal area (Ai) and wall thickness (WT) of third- to sixth-generation bronchi were measured and adjusted by body surface area (BSA; Ai/BSA and WT/√BSA, respectively). Patients with ACO had higher respiratory resistance and reactance during tidal breathing, but a smaller gap between the inspiratory and expiratory phases, compared with matched patients with COPD. Patients with ACO had a greater WT/√BSA in third- to fourth-generation bronchi, smaller Ai/BSA in fifth- to sixth-generation bronchi, and less emphysematous changes than did matched patients with COPD. Even when patients with ACO and those with COPD have a comparable smoking history and fixed airflow limitation, they have different physiological and morphological features of the airways.

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Section: Methodsmentioning

confidence: 99%

Physiological and morphological differences of airways between COPD and asthma–COPD overlap

Karayama

Inui

Yasui

et al. 2019

Sci Rep

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“…Subcutaneous fat area is positively associated with bronchial WA, which might be a marker for airway remodeling in asthma. 29 …”

Section: Discussionmentioning

confidence: 99%

Association Between Airway Parameters and Abdominal Fat Measured via Computed Tomography in Asthmatic Patients

Yang

Choi

et al. 2018

Allergy Asthma Immunol Res

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PurposeWe aimed to investigate whether airway parameters, assessed via computed tomography (CT), are associated with abdominal fat areas and to compare the clinical characteristics of asthmatic patients with and without elevated visceral to subcutaneous fat area ratio (EV).MethodsAsthmatic patients (aged ≥40 years) were prospectively recruited. Chest (airway) and fat areas were assessed via CT. Airway parameters, including bronchial wall thickness (WT), lumen diameter (LD), lumen area (LA), wall area (WA), total area (TA), as well as WA/TA percentage (wall area %) were measured at the apical segmental bronchus in the right upper lobe. Visceral (VFA), subcutaneous (SFA) and total (TFA) fat areas (cm2) were also measured. The correlations between abdominal fat areas and airway parameters were assessed. EV was defined as VFA/SFA ≥ 0.4.ResultsFifty asthmatic patients were included (mean age 62.9 years; 52% female); 38% had severe asthma. Significant correlations were found between VFA and both LD and LA (r = −0.35, P = 0.01; r = −0.34, P = 0.02, respectively), and SFA and both WA and TA (r = 0.38, P = 0.007; r = 0.34, P = 0.02, respectively). Exacerbations, requiring corticosteroid therapy or ER visitation, were significantly more frequent in subjects without EV (83% vs. 34%, P = 0.05).ConclusionsAbdominal fat is associated with asthma, according to the location of fat accumulation. In asthmatic subjects, visceral fat seems to be attributable to the bronchial luminal narrowing, while subcutaneous fat may be related to thickening of bronchial wall.

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“…The segmental bronchus was defined as the 3rd generation airway. Following automatic luminal segmentation of the airway tree, all branches of the 3rd to 6th generation airways in all segments were manually identified by tracking from the 3rd to the 6th generation [ 5 , 21 ]. For each branch, cross-sectional images perpendicular to the longitudinal center line of the lumen were generated, and the lumen areas and internal diameters in the middle third portion were automatically measured and averaged.…”

Section: Methodsmentioning

confidence: 99%

Differences in airway lumen area between supine and upright computed tomography in patients with chronic obstructive pulmonary disease

Chubachi

Yamada

et al. 2021

Respir Res

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Background No clinical studies to date have compared the inspiratory and expiratory airway lumen area between supine and standing positions. Thus, the aims of this study were twofold: (1) to compare inspiratory and expiratory airway lumen area (IAA and EAA, respectively) on computed tomography (CT) among supine and standing positions; and (2) to investigate if IAA and EAA are associated with lung function abnormality in patients with chronic obstructive pulmonary disease (COPD). Methods Forty-eight patients with COPD underwent both low-dose conventional (supine position) and upright CT (standing position) during inspiration and expiration breath-holds and a pulmonary function test (PFT) on the same day. We measured the IAA and EAA in each position. Results For the trachea to the third-generation bronchi, the IAA was significantly larger in the standing position than in the supine position (4.1–4.9% increase, all p < 0.05). The EAA of all bronchi was significantly larger in the standing position than in the supine position (9.7–62.5% increases, all p < 0.001). The correlation coefficients of IAA in the standing position and forced expiratory volume in 1 s were slightly higher than those in the supine position. The correlation coefficients of EAA or EAA/IAA in the standing position and residual volume, and the inspiratory capacity/total lung capacity ratio were higher than those in the supine position. Conclusions Airway lumen areas were larger in the standing position than in the supine position. IAAs reflect airway obstruction, and EAAs reflect lung hyperinflation. Upright CT might reveal these abnormalities more precisely. Trial registration University Hospital Medical Information Network (UMIN 000026587), Registered 17 March 2017. URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000030456.

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Relationship between fraction of exhaled nitric oxide and airway morphology assessed by three-dimensional CT analysis in asthma

Cited by 28 publications

References 52 publications

Physiological and morphological differences of airways between COPD and asthma–COPD overlap

Physiological and morphological differences of airways between COPD and asthma–COPD overlap

Association Between Airway Parameters and Abdominal Fat Measured via Computed Tomography in Asthmatic Patients

Differences in airway lumen area between supine and upright computed tomography in patients with chronic obstructive pulmonary disease

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