The effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokines

Ferreira, Leonardo L. G.; Gomes‐Filho, João Eduardo; Benetti, Francine; Carminatti, Marina; Ervolino, Edílson; Briso, André Luiz Fraga; Cintra, Luciano Tavares Ângelo

doi:10.1111/iej.12852

Cited by 24 publications

(49 citation statements)

References 47 publications

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“…This disagreement can be attributed to the different ways interleukins were analysed: In the present study, interleukins were analysed in the entire coronal pulp instead of an analysis of coronal pulp thirds, according to a previous study (Ferreira et al . ).…”

Section: Discussionmentioning

confidence: 97%

Concentration‐dependent effect of bleaching agents on the immunolabelling of interleukin‐6, interleukin‐17 and CD5‐positive cells in the dental pulp

et al. 2018

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Section: Discussionmentioning

confidence: 97%

Concentration‐dependent effect of bleaching agents on the immunolabelling of interleukin‐6, interleukin‐17 and CD5‐positive cells in the dental pulp

et al. 2018

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“…, Ferreira et al . ). In this case, the necrosis and inflammation promoted is of chemical origin, without the participation of microorganisms.…”

Section: Review Of Identified Publicationsmentioning

confidence: 97%

The Presence and involvement of interleukin‐17 in apical periodontitis

2019

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Apical periodontitis (AP) is a chronic inflammatory disease characterized by periapical tissue inflammation and destruction of the associated alveolar bone. It is caused by microbial infections within the root canal and the resultant host immune responses in the periapical tissues. The proinflammatory cytokine interleukin (IL)‐17 has been shown to play an important role in many inflammatory diseases. There is increasing evidence of the presence of IL‐17 in AP, which might be associated with disease pathogenesis. Moreover, several animal studies indicate the potential role of IL‐17 in periapical inflammation and the resultant bone resorption in AP. This article reviews recent studies regarding the collective in vitro, in vivo and clinical evidence of the presence and involvement of IL‐17 in AP. A search related to IL‐17 in apical periodontitis was conducted on PubMed, EMBASE and Web of Science databases using keywords and controlled vocabulary. Two independent reviewers first screened titles and abstracts and then the full texts that were included. A total of 25 papers were identified, of the 25 included articles, 7 involved laboratory studies on cell cultures, 11 involved animal experimentations, and 7 were observational studies using human clinical samples. In conclusion, evidence for the presence of IL‐17 in AP from human and animal models is clear. However, there is relatively little information currently available that would highlight the specific role of IL‐17 in AP.

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“…, Ferreira et al . ) for osteocalcin, osteopontin and ROS. The first slide obtained with histological sections was selected for H.E.…”

Section: Methodsmentioning

confidence: 99%

“…, Ferreira et al . ). The effects of this action range from inflammation, which may be minimal depending on the thickness of enamel and dentine (Kina et al .…”

Section: Introductionmentioning

confidence: 97%

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The presence of osteocalcin, osteopontin and reactive oxygen species‐positive cells in pulp tissue after dental bleaching

et al. 2018

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Aim To analyse the influence of H2O2 on pulp repair through osteocalcin and osteopontin immunolabelling and in cellular defence by using the antireactive oxygen species (ROS) antibody. Methodology The maxillary molars of 50 rats were treated with 35% H2O2 (Ble groups) or placebo gel (control groups). At 0 h and 2, 7, 15 and 30 days (n = 10 hemimaxillae), the rats were killed and pulp tissue was evaluated using inflammation and immunolabelling scores (osteocalcin/osteopontin); ROS‐positive cells were counted. Paired t‐test and Wilcoxon signed‐rank test were used (P < 0.05). Results The Ble group had necrosis in the coronal pulp at 0 h and in the occlusal third of the coronal pulp at 2 days; at 7, 15 and 30 days, no inflammation was noted similar to the controls (P > 0.05). Osteocalcin was absent in the Ble at 0 h, moderate at 2 days and increased thereafter, differing from the controls at all two periods (P < 0.05). Osteopontin was higher principally at 7 and 15 days in Ble groups, but differing with control groups from 2 days after bleaching (P < 0.05). The Ble group had more ROS‐positive cells in the pulp at 7 and 15 days (P < 0.05). Tertiary dentine was observed at 7 days, increasing thereafter (P < 0.05). Conclusions Post‐bleaching pulp repair was associated with increased osteocalcin over time. Osteopontin also participated in this process, and anti‐ROS was involved in cellular defence against H2O2.

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The effect of dental bleaching on pulpal tissue response in a diabetic animal model: a study of immunoregulatory cytokines

Abstract: Tooth bleaching increased IL-6 and TNF-α in the pulp tissue regardless of diabetes mellitus; however, diabetic rats had higher TNF-α levels for longer periods. Tooth bleaching influenced the increase in IL-17 in the early periods in normoglycaemic rats.

Cited by 24 publications

References 47 publications

Concentration‐dependent effect of bleaching agents on the immunolabelling of interleukin‐6, interleukin‐17 and CD5‐positive cells in the dental pulp

Concentration‐dependent effect of bleaching agents on the immunolabelling of interleukin‐6, interleukin‐17 and CD5‐positive cells in the dental pulp

The Presence and involvement of interleukin‐17 in apical periodontitis

The presence of osteocalcin, osteopontin and reactive oxygen species‐positive cells in pulp tissue after dental bleaching

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