Antiviral therapy of chronic HBV infection in pregnancy

Abstract

We describe a 27-year-old hepatitis B virus (HBV)-infected pregnant woman, with a history of miscarriage a year ago. The patient has been HBsAg and HBeAg positive for 20 years but has never been treated for HBV infection, because of stable elevated alanine aminotransferase (ALT) activity and high viral load. Treatment with tenofovir disoproxil was introduced in the 10th week of pregnancy and HBV DNA became undetectable. The clinical course of pregnancy was normal and the patient gave birth by caesarean section to a healthy child. At birth the newborn was HBsAg negative, after 3 months of follow-up is healthy, and evaluation of HBV status will be scheduled shortly. The decision to treat HBV infection during pregnancy should be individualized.

Approach to women who become pregnant while on tenofovir disoproxil fumarate for chronic B hepatitis: A report of two cases

“…7 When the literature is reviewed, case reports show that the use of TDF in pregnant women is safe and effective. [24][25][26] Although there are studies supporting the treatment and prophylaxis of TDF, there are those showing that it does not significantly reduce transmission. In a study conducted in Thailand, mothers were given TDF and placebo after 28 weeks and no significant difference was found between the two groups neither in terms of adverse effects nor lower the rate of vertical transmission.…”