Löffler Endocarditis and Endomyocardial Fibrosis

Flanigan, Matthew J.; Velez, Michael R.; Ruden, Emily; Lilly, Scott

doi:10.7556/jaoa.2017.115

Cited by 2 publications

(1 citation statement)

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“…Therefore, diagnosis may be a challenge. The main morbidity and mortality of HES patients are cardiovascular complications [Flanigan 2017]. Heart involvement may be present in 50% to 60% of patients, which constitutes Loffler endocarditis.…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment of Loffler Endocarditis in an 8-Year-Old Girl

Guo

Fan

et al. 2020

HSF

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Background: Idiopathic hyper eosinophilic syndrome (HES) is a rare disease characterized by a sustained increase in eosinophilia. Heart involvement is called Loffler endocarditis. Loffler endocarditis is a serious complication of hyper eosinophilia syndrome, which is characterized by a special type of fibrotic endocarditis. Loffler endocarditis is an inflammatory cardiac condition characterized by eosinophilic infiltration in the heart. The overall prognosis for patients with Loffler endocarditis is very poor. Methods: In this article we report an 8-year-old girl who was diagnosed as having Loffler endocarditis in thrombotic phase and was successfully treated with surgery. Results: Our patient had a good prognosis during the half-year follow-up. She had no symptoms of heart failure and echocardiography findings were normal. Conclusion: The cardiac damage occurred in a three-stage process: the necrotic, thrombotic, and fibrotic stages. This unusual but sometimes life-threatening disease is often detected in the late phase, resulting in no curative strategy available to reverse the disease process. The overall prognosis of patients with Loffler endocarditis is very poor. Current treatments include anticoagulation and anti-eosinophils therapy, and surgery only in selected cases. Surgical treatment of HES in adolescents is very rare. The present case illustrates that with well-controlled peripheral eosinophilia, proper surgical treatment in selected patients can improve their prognosis in the near future but long-term follow-up is necessary.

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Section: Discussionmentioning

confidence: 99%