Left hemispheric breakdown of LTP-like cortico-cortical plasticity in schizophrenic patients

Ribolsi, Michele; Lisi, Giulia; Ponzo, Viviana; Siracusano, Alberto; Caltagirone, Carlo; Niolu, Cinzia; Koch, Giacomo

doi:10.1016/j.clinph.2017.06.255

Cited by 10 publications

(9 citation statements)

References 53 publications

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“…The study of brain network reorganization in response to brain damage could help to shed light on the relationship between synaptic plasticity and brain network remodeling. Particular neuropsychiatric conditions, such as schizophrenia and AD, in which altered plasticity is one main neurophysiological feature [86,87], may represent useful models to investigate how synaptic plasticity alterations impact brain network architecture. Notably, the central role of plasticity alteration has also been proposed in other neurological conditions such as temporal lobe epilepsy.…”

Section: Synaptic Plasticity and Brain Network Organizationmentioning

confidence: 99%

“…AD and schizophrenia could represent useful models to explore the relationship between LTP expression and hubs connectivity. In particular, in AD and schizophrenia, impaired plasticity [87,119] may be responsible for reduced hubs degree and centrality, and decreased rich club connectivity [7,31,120]. In particular, impaired synaptic plasticity alters the synchrony of both local and distributed neuronal oscillations and could promote brain network dysfunction [69,121,122].…”

Section: Synaptic Plasticity Dysfunction May Drive Brain Network Disrmentioning

confidence: 99%

“…Recently, disrupted synaptic plasticity has been proposed as a possible pathophysiological marker of schizophrenia [87,150,151]. Accordingly, reduced spine density has been described in the prefrontal and temporal cortices of schizophrenic patients [152][153][154][155], and altered expression and function of NMDARs and AMPARs have been reported [156][157][158][159][160].…”

Section: Synaptic Plasticity Dysfunction May Drive Brain Network Disrmentioning

confidence: 99%

“…Impaired LTP and LTD-like plasticity has been consistently reported in patients with schizophrenia [150,151,162]. Using a TMS protocol useful to explore cortical connectivity and in particular spike timing-dependent plasticity [163,164], reduced LTP-like plasticity has been shown between posterior parietal and frontal cortices in schizophrenia compared to control subjects [87].…”

Section: Synaptic Plasticity Dysfunction May Drive Brain Network Disrmentioning

confidence: 99%

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Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology

Bassi

Iezzi

Gilio

et al. 2019

IJMS

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Studies of brain network connectivity improved understanding on brain changes and adaptation in response to different pathologies. Synaptic plasticity, the ability of neurons to modify their connections, is involved in brain network remodeling following different types of brain damage (e.g., vascular, neurodegenerative, inflammatory). Although synaptic plasticity mechanisms have been extensively elucidated, how neural plasticity can shape network organization is far from being completely understood. Similarities existing between synaptic plasticity and principles governing brain network organization could be helpful to define brain network properties and reorganization profiles after damage. In this review, we discuss how different forms of synaptic plasticity, including homeostatic and anti-homeostatic mechanisms, could be directly involved in generating specific brain network characteristics. We propose that long-term potentiation could represent the neurophysiological basis for the formation of highly connected nodes (hubs). Conversely, homeostatic plasticity may contribute to stabilize network activity preventing poor and excessive connectivity in the peripheral nodes. In addition, synaptic plasticity dysfunction may drive brain network disruption in neuropsychiatric conditions such as Alzheimer’s disease and schizophrenia. Optimal network architecture, characterized by efficient information processing and resilience, and reorganization after damage strictly depend on the balance between these forms of plasticity.

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Section: Synaptic Plasticity and Brain Network Organizationmentioning

confidence: 99%

Section: Synaptic Plasticity Dysfunction May Drive Brain Network Disrmentioning

confidence: 99%

Section: Synaptic Plasticity Dysfunction May Drive Brain Network Disrmentioning

confidence: 99%

Section: Synaptic Plasticity Dysfunction May Drive Brain Network Disrmentioning

confidence: 99%

See 2 more Smart Citations

Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology

Bassi

Iezzi

Gilio

et al. 2019

IJMS

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“…97 Similarly, elevated levels of Impaired Hebbian plasticity + (89) ? + + (148,149) 0/ + (154)(155)(156) Impaired homeostatic plasticity + (143) ? 0 / + (150) ?…”

Section: Inflammation and Cognition In Bipolar Disordermentioning

confidence: 99%

Neuroinflammation and cognition across psychiatric conditions

2019

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Cognitive impairments reported across psychiatric conditions (ie, major depressive disorder, bipolar disorder, schizophrenia, and posttraumatic stress disorder) strongly impair the quality of life of patients and the recovery of those conditions. There is therefore a great need for consideration for cognitive dysfunction in the management of psychiatric disorders. The redundant pattern of cognitive impairments across such conditions suggests possible shared mechanisms potentially leading to their development. Here, we review for the first time the possible role of inflammation in cognitive dysfunctions across psychiatric disorders. Raised inflammatory processes (microglia activation and elevated cytokine levels) across diagnoses could therefore disrupt neurobiological mechanisms regulating cognition, including Hebbian and homeostatic plasticity, neurogenesis, neurotrophic factor, the HPA axis, and the kynurenine pathway. This redundant association between elevated inflammation and cognitive alterations across psychiatric disorders hence suggests that a cross-disorder approach using pharmacological and nonpharmacological (ie, physical activity and nutrition) anti-inflammatory/immunomodulatory strategies should be considered in the management of cognition in psychiatry.

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Cortico-cortical connectivity: the road from basic neurophysiological interactions to therapeutic applications

Koch

2020

Exp Brain Res

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Left hemispheric breakdown of LTP-like cortico-cortical plasticity in schizophrenic patients

Cited by 10 publications

References 53 publications

Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology

Synaptic Plasticity Shapes Brain Connectivity: Implications for Network Topology

Neuroinflammation and cognition across psychiatric conditions

Cortico-cortical connectivity: the road from basic neurophysiological interactions to therapeutic applications

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