Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery

Tamayol, Ali; Najafabadi, Alireza Hassani; Mostafalu, Pooria; Yetisen, Ali K.; Commotto, Mattia; Aldhahri, Musab; Abdel-wahab, M. Sh.; Najafabadi, Zeynab Izadi; Latifi, Shahrzad; Akbari, Mohsen; Annabi, Nasim; Yun, Seok Hyun; Memić, Adnan; Dokmeci, Mehmet R.; Khademhosseini, Ali

doi:10.1038/s41598-017-04749-8

Cited by 96 publications

(88 citation statements)

References 44 publications

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“…Such capability does not exist in any existing bandages. Also, almost all the current methods and systems used for controlling drug release in the treatment of wound care are designed for topical delivery of drugs 7,15. This is due to the ease‐of‐access to the wound site, which allows for the localized delivery of therapeutics.…”

Section: Resultsmentioning

confidence: 99%

“…Impaired angiogenesis significantly limits the availability of vital nutrients, oxygen, immune cells, and epithelial cells at the injury site. Without oxygen and nutrients, areas of necrotic tissue grow, which are conducive to the growth of biofilms 7. The formed biofilms on top of the wound bed are resistant to treatment by topical and systemic delivery of antibiotics 5…”

Section: Introductionmentioning

confidence: 99%

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A Wirelessly Controlled Smart Bandage with 3D‐Printed Miniaturized Needle Arrays

Derakhshandeh

Aghabaglou

McCarthy

et al. 2020

Adv Funct Materials

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134

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Chronic wounds are one of the most devastating complications of diabetes and are the leading cause of nontraumatic limb amputation. Despite the progress in identifying factors and promising in vitro results for the treatment of chronic wounds, their clinical translation is limited. Given the range of disruptive processes necessary for wound healing, different pharmacological agents are needed at different stages of tissue regeneration. This requires the development of wearable devices that can deliver agents to critical layers of the wound bed in a minimally invasive fashion. Here, for the first time, a programmable platform is engineered that is capable of actively delivering a variety of drugs with independent temporal profiles through miniaturized needles into deeper layers of the wound bed. The delivery of vascular endothelial growth factor (VEGF) through the miniaturized needle arrays demonstrates that, in addition to the selection of suitable therapeutics, the delivery method and their spatial distribution within the wound bed is equally important. Administration of VEGF to chronic dermal wounds of diabetic mice using the programmable platform shows a significant increase in wound closure, re‐epithelialization, angiogenesis, and hair growth when compared to standard topical delivery of therapeutics.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Wirelessly Controlled Smart Bandage with 3D‐Printed Miniaturized Needle Arrays

Derakhshandeh

Aghabaglou

McCarthy

et al. 2020

Adv Funct Materials

Self Cite

134

View full text Add to dashboard Cite

show abstract

“…In vitro studies showed that the patch successfully released cefazolin in agar plates inoculated with Staphylococcus aureus and E. coli . Wound patches (1.5 cm in diameter) having heaters resulted in a zone of inhibition up to 1.0 cm over 24 h as compared to control samples without a heater …”

Section: The Rise Of Personalized Medicinementioning

confidence: 97%

“…A biodegradable electronic patch integrated with flexible heaters was developed to deliver drugs on demand . This thermally‐controllable patch allowed administering antibiotics.…”

Section: The Rise Of Personalized Medicinementioning

confidence: 99%

Wearables in Medicine

et al. 2018

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Wearables as medical technologies are becoming an integral part of personal analytics, measuring physical status, recording physiological parameters, or informing schedule for medication. These continuously evolving technology platforms do not only promise to help people pursue a healthier life style, but also provide continuous medical data for actively tracking metabolic status, diagnosis, and treatment. Advances in the miniaturization of flexible electronics, electrochemical biosensors, microfluidics, and artificial intelligence algorithms have led to wearable devices that can generate real-time medical data within the Internet of things. These flexible devices can be configured to make conformal contact with epidermal, ocular, intracochlear, and dental interfaces to collect biochemical or electrophysiological signals. This article discusses consumer trends in wearable electronics, commercial and emerging devices, and fabrication methods. It also reviews real-time monitoring of vital signs using biosensors, stimuli-responsive materials for drug delivery, and closed-loop theranostic systems. It covers future challenges in augmented, virtual, and mixed reality, communication modes, energy management, displays, conformity, and data safety. The development of patient-oriented wearable technologies and their incorporation in randomized clinical trials will facilitate the design of safe and effective approaches.

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“…However, there also exist medical conditions which require implantable devices to work only over well‐defined periods of time. These include various applications such as monitoring, stimulating, and treating central and peripheral nervous systems after a surgery or a traumatic injury, localized drug delivery for wound healing or following a surgical procedure, as well as pressure and strain monitoring on tendons during rehabilitation after surgical repair . For such usage, transient medical devices which resorb after some time are beneficial.…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Frequency‐Selective Magnesium Radio‐Frequency Microresonators for Transient Biomedical Implants

Rüegg

Blum

Boero

et al. 2019

Adv Funct Materials

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Bioresorbable implantable medical devices show a great potential for applications requiring medical care over well-defined periods of time. Once their function is fulfilled, such implants naturally degrade and resorb in the body, which eliminates adverse long-term effects or the need for a secondary surgery to extract the implanted device. Since biodegradable materials are water-soluble, the fabrication of such transient electronic circuits and devices requires special care and needs to rely solely on dry processing steps without exposure to aqueous solutions. A further challenge is the in vivo powering of medical implants that are only constituted of biodegradable materials. This paper describes the design, fabrication, and testing of radio-frequency biodegradable magnesium microresonators. To this end, an innovative microfabrication process with minimal exposure to aqueous media is developed to fabricate magnesiumbased, water-soluble electronic components. It consists of a novel sequence of only three steps: one physical vapor deposition, one photolithography, and one ion beam etching step. The frequency-selective wireless heating of different resonators is demonstrated. This represents a significant step toward their use as power receivers and microheaters in biodegradable implantable medical devices, for applications such as triggered drug release.

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Biodegradable elastic nanofibrous platforms with integrated flexible heaters for on-demand drug delivery

Cited by 96 publications

References 44 publications

A Wirelessly Controlled Smart Bandage with 3D‐Printed Miniaturized Needle Arrays

A Wirelessly Controlled Smart Bandage with 3D‐Printed Miniaturized Needle Arrays

Wearables in Medicine

Biodegradable Frequency‐Selective Magnesium Radio‐Frequency Microresonators for Transient Biomedical Implants

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