“…Researchers seeking to test hypotheses in a specific cellular context may opt for a focused analysis of individual protein complexes rather than the “representative” biochemical networks provided by large‐scale studies. In such cases, tandem affinity purification remains the method of choice to provide insights into protein function and to address mechanistic gaps in our interpretation of genotype‐phenotype relationships (Adelmant et al., ; Cato et al., ; Chen et al., ; Doherty, Adelmant, Cecchetelli, Marto, & Cram, ; Duarte et al., ; Durzynska et al., ; Ferry et al., ; Fine et al., ; Goudreault et al., ; Hill et al., ; Hwang et al., ; Jager et al., ; Kim et al., ; Koleva et al., ; Lee et al., ; Mathias et al., ; Meijer et al., ; Miotto et al., ; Pathania et al., ; Pichlmair et al., ; Quan et al., ; Rozenblatt‐Rosen et al., ; Sand‐Dejmek et al., ; Simarro et al., ; Uljon et al., ; Wang et al., ; Watanabe et al., ; Wei, Chiang, Sumpter, Mishra, & Levine, ; Zhang et al., ; Zhang et al., ; Zhou et al., ).…”