Chemotaxis‐Guided Hybrid Neutrophil Micromotors for Targeted Drug Transport

Shao, Jianzhong; Xuan, Mingjun; Zhang, Hongyue; Lin, Xiankun; Wu, Zhiguang; He, Qiang

doi:10.1002/anie.201706570

Cited by 177 publications

(160 citation statements)

References 44 publications

Supporting

Mentioning

157

Contrasting

Unclassified

Order By: Relevance

“…[9] Ferrite coatings were also incorporated in magnetically propelled helices for prolonged navigation in blood. [11] Then ative fluorescence of Spirulina microalgae was exploited for the construction of magnetic micromotors for bioimaging applications. [11] Then ative fluorescence of Spirulina microalgae was exploited for the construction of magnetic micromotors for bioimaging applications.…”

Section: Introductionmentioning

confidence: 99%

Visible‐Light‐Driven Janus Microvehicles in Biological Media

2019

View full text Add to dashboard Cite

Alight-driven multifunctional Janus micromotor for the removal of bacterial endotoxins and heavy metals is described. The micromotor was assembled by using the biocompatible polymer polycaprolactone for the encapsulation of CdTeo rC dSe@ZnS quantum dots (QDs) as photoactive materials and an asymmetric Fe 3 O 4 patch for propulsion. The micromotors can be activated with visible light (470-490 nm) to propel in peroxide or glucose media by adiffusiophoretic mechanism. Efficient propulsion was observed for the first time in complex samples such as human blood serum. These properties were exploited for efficient endotoxinremoval using lipopolysaccharides from Escherichia coli O111:B4 as am odel toxin. The micromotors were also used for mercury removal by cationic exchange with the CdSe@ZnS core-shell QDs.C ytotoxicity assays in HeLa cell lines demonstrated the high biocompatibility of the micromotors for future detoxification applications.Supportinginformation and the ORCID identification number(s) for the author(s) of this article can be found under: https://doi.

show abstract

Section: Introductionmentioning

confidence: 99%

Visible‐Light‐Driven Janus Microvehicles in Biological Media

2019

View full text Add to dashboard Cite

show abstract

“…The similar trajectories have been reported by previous research which showed a chemotaxis behavior of micromotors. [ 36 ] Brownian motion was observed for functionalized particles with nontriggered cells (Figure S9, Supporting Information). In a real periodontal pocket, the concentration of H 2 O 2 is expected to be higher than the experimental condition because there exist much more immune cells.…”

Section: Resultsmentioning

confidence: 99%

Self‐Propelled PLGA Micromotor with Chemotactic Response to Inflammation

Wang

Toebes²,

Plachokova

et al. 2020

Adv Healthcare Materials

View full text Add to dashboard Cite

Local drug delivery systems have recently been developed for multiple diseases that have the requirements of site‐specific actions, prolonged delivery periods, and decreased drug dosage to reduce undesirable side effects. The challenge for such systems is to achieve directional and precise delivery in inaccessible narrow lesions, such as periodontal pockets or root canals in deeper portions of the dentinal tubules. The primary strategy to tackle this challenge is fabricating a smart tracking delivery system. Here, drug‐loaded biodegradable micromotors showing self‐propelled directional movement along a hydrogen peroxide concentration gradient produced by phorbol esters‐stimulated macrophages are reported. The drug‐loaded poly(lactic‐co‐glycolic acid) micromotors with asymmetric coverage of enzyme (patch‐like enzyme distribution) are prepared by electrospraying and postfunctionalized with catalase via 1‐ethyl‐3‐(3‐dimethylaminopropyl) carbodiimide coupling. Doxycycline, a common drug for the treatment of periodontal disease, is selected as a model drug, and the release study by high‐performance liquid chromatography is shown that both the postfunctionalization step and the presence of hydrogen peroxide have no negative influence on drug release profiles. The movement behavior in the presence of hydrogen peroxide is confirmed by nanoparticle tracking analysis. An in vitro model is designed and confirmed the response efficiency and directional control of the micromotors toward phorbol esters‐stimulated macrophages.

show abstract

“…As stated in their cell-killing results, DOX-loaded cells significantly inhibited the proliferation of tumor cells compared with unloaded cells. Shao et al developed a hybrid neutrophil micromotor system which was guided along the chemoattractant gradients secreted by Escherichia coli for targeted drug transport ( Figure 3B & Table 2) [79]. In their research, DOX was embedded within mesoporous silica nanoparticles and then taken up by the neutrophils.…”

Section: Cells/microorganisms As Drug Carriersmentioning

confidence: 99%

Micro- and nano-motors: the New Generation of Drug Carriers

2018

View full text Add to dashboard Cite

Micro-and nano-motors are emerging as novel drug delivery platforms, offering advantages such as rapid drug transport, high tissue penetration and motion controllability. They can be propelled and/or guided by endogenous (i.e., chemotaxis) or exogenous stimuli (e.g., ultrasound, magnetic fields, light) toward the area of interest. Moreover, such stimuli can be used to trigger the release of a therapeutic payload when the motor reaches certain location in order to improve the drug targeting. In this review article, we highlight medically oriented micro-/nano-motors, in particular the ones created for targeted drug delivery, and discuss their current limitations and possibilities toward in vivo applications. Drug-delivery systems have greatly evolved since 1952, when the first sustained release systems were introduced (see the graphical abstract) [1]. In the 1980s, self-regulated drug release carriers as well as the first drug delivery nanostructures were developed. From then on, research in this field has been focused on improving the targeting and systemic circulation of those carriers as well as to study different nanoparticle-based drug formulations, topics which have been widely reviewed in the literature [2][3][4][5][6][7]. Several nanocarriers (between 5 and 200 nm diameter) have been explored for therapy (e.g. inorganic, polymeric, liposomes, nanocrystals, nanotubes and dendrimers) [8], many of them already approved by the Food and Drug Administration (FDA) to treat, for example, neurovascular diseases, neurological cancers and neurodegenerative maladies [9]. The study of their pharmacokinetics has led to the creation of new carriers with reduced drug dose and protection from efflux or degradation [10]. Most of these nanocarriers include sophisticated surface biofunctionalization and coatings like polyethylene glycol (PEG) [11] or biomimetic modifications, [12] to increase their specificity and circulation time [13]. However, challenges still remain for those carriers such as the improvement of their targeting (currently only about 0.7% -median -of the administrated nanoparticle dose is found to be delivered to a solid tumor [14]), their penetration ability, drug loading capacity and delivery on the subcellular level. Other type of drug carriers are the cellular ones, which have many advantages such Graphical abstract:

show abstract

Chemotaxis‐Guided Hybrid Neutrophil Micromotors for Targeted Drug Transport

Cited by 177 publications

References 44 publications

Visible‐Light‐Driven Janus Microvehicles in Biological Media

Visible‐Light‐Driven Janus Microvehicles in Biological Media

Self‐Propelled PLGA Micromotor with Chemotactic Response to Inflammation

Micro- and nano-motors: the New Generation of Drug Carriers

Contact Info

Product

Resources

About