2017
DOI: 10.1189/jlb.3a0816-357rr
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Galectin-8 activates dendritic cells and stimulates antigen-specific immune response elicitation

Abstract: Galectin-8 (Gal-8) is a mammalian β-galactoside-binding lectin, endowed with proinflammatory properties. Given its capacity to enhance antigen-specific immune responses in vivo, we investigated whether Gal-8 was also able to promote APC activation to sustain T cell activation after priming. Both endogenous [dendritic cells (DCs)] and bone marrow-derived DCs (BMDCs) treated with exogenous Gal-8 exhibited a mature phenotype characterized by increased MHC class II (MHCII), CD80, and CD86 surface expression. Moreo… Show more

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Cited by 33 publications
(48 citation statements)
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References 48 publications
(69 reference statements)
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“…These findings are in agreement with our previous observations where both MHCII int CD11b high and MHC high CD11b int BMDC subpopulations, which resemble cDC and monocyte‐derived macrophages respectively, produce IL‐6 in response to Gal‐8 stimulation. Moreover, IL‐6 secretion was impaired in BMDC differentiated from Gal‐8 knockout (Gal‐8KO) mice, suggesting a physiological role for endogenous Gal‐8 in the regulation of IL‐6 production . Regarding B cells, and also in line with our findings, Tsai et al .…”
Section: Resultssupporting
confidence: 88%
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“…These findings are in agreement with our previous observations where both MHCII int CD11b high and MHC high CD11b int BMDC subpopulations, which resemble cDC and monocyte‐derived macrophages respectively, produce IL‐6 in response to Gal‐8 stimulation. Moreover, IL‐6 secretion was impaired in BMDC differentiated from Gal‐8 knockout (Gal‐8KO) mice, suggesting a physiological role for endogenous Gal‐8 in the regulation of IL‐6 production . Regarding B cells, and also in line with our findings, Tsai et al .…”
Section: Resultssupporting
confidence: 88%
“…In summary, the in vitro model used throughout this work allowed us to show the participation of IL‐6 signalling in Gal‐8‐induced co‐stimulation during the elicitation of the antigen‐specific CD4 T‐cell response. As IL‐6 is a key cytokine involved in the differentiation of Tfh cells and germinal centre formation, our findings support a plausible mechanism by which Gal‐8 stimulates the antigen‐specific protective humoral response previously observed in a viral vaccine model . Interestingly, aged CD4 T cells require higher levels of IL‐6 produced during the CD4 T cell : APC cognate interaction compared with young CD4 T cells, to effectively induce IL‐6 signalling, read out as IgG antibody production .…”
Section: Resultssupporting
confidence: 88%
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“…(GRO-γ) and CXCL8 (IL-8), in a process that requires activation of NFkB (112). Gal-8 also increases secretion of a number of chemokines and cytokines (i.e., IL-3, IL-2, IL-6, TNF-α, MCP-1, and MCP-5) from bone marrow-derived dendritic cells (113). Most relevant are the observations that increased circulating Gal-8 in (Fig.…”
Section: Modulation Of Cell-matrix Interactionsmentioning
confidence: 99%