A New Mouse Model of APOL1 -Associated Kidney Diseases: When Traffic Gets Snarled, the Podocyte Suffers

O’Toole, John F.; Bruggeman, Leslie A.; Sedor, John R.

doi:10.1053/j.ajkd.2017.07.002

Cited by 2 publications

(3 citation statements)

References 39 publications

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“…Investigators have recently developed knockout mouse models of APOL1-associated kidney diseases that are helping to elucidate mechanisms. 22,23…”

Section: Mechanism Not Well Understoodmentioning

confidence: 99%

“…In a recent commentary related to the murine knockout model of APOL1-associated kidney disease, O'Toole et al offered insightful observations regarding the potential clinical impact of these new genetic discoveries. 23 As we study the genetics of kidney disease in African American patients, we should keep in mind 3 critical questions of clinical importance:…”

Section: ■ Keeping Science Relevantmentioning

confidence: 99%

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Chronic kidney disease in African Americans: Puzzle pieces are falling into place

Nally¹

2017

CCJM

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Recent decades have seen great advances in the understanding of chronic kidney disease, spurred by standardizing disease definitions and large-scale patient surveillance. African Americans are disproportionately affected by the disease, and recently discovered genetic variants in APOL1 that protect against sleeping sickness in Africa provide an important explanation for the increased burden. Studies are now under way to determine if genetic testing of African American transplant donors and recipients is advisable.

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“…Investigators have recently developed knockout mouse models of APOL1-associated kidney diseases that are helping to elucidate mechanisms. 22,23…”

Section: Mechanism Not Well Understoodmentioning

confidence: 99%

Section: ■ Keeping Science Relevantmentioning

confidence: 99%

Chronic kidney disease in African Americans: Puzzle pieces are falling into place

Nally¹

2017

CCJM

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“…Many, but not all, studies suggest that APOL1 variant‐dependent cytotoxicity is associated with kidney diseases (also reviewed in Ref. [1‐4]). Furthermore, animal models have linked changes in podocyte number with APOL1 genotype.…”

Section: Introductionmentioning

confidence: 99%

Podocyte density is reduced in kidney allografts with high‐risk APOL1 genotypes at transplantation

Chen

Zaky

Schold

et al. 2021

Clinical Transplantation

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The biology that explains the association of APOL1 variants with nondiabetic kidney diseases in black patients remains controversial.Many, but not all, studies suggest that APOL1 variant-dependent cytotoxicity is associated with kidney diseases (also reviewed in Ref.[1-4]). Furthermore, animal models have linked changes in podocyte number with APOL1 genotype. We previously demonstrated podocyte depletion in transgenic mice constitutively expressing the G2 variant of APOL1 in podocytes under the Nephrin promoter (Nphs1. APOL1-G2), but not in wild type or APOL1-G0 expressing (Nphs1. APOL1-G0) mice, despite normal biochemical and histologic kidney phenotypes. 5 Mice with HIV-associated nephropathy (HIVAN) and transgenic for Nphs1.APOL-G0 had preserved podocyte numbers and densities; whereas, HIVAN mice with Nphs1.APOL1-G2 had podocyte numbers and density similar to HIVAN only mice. 6 The podocyte depletion hypothesis proposes that the progressive podocyte loss occurs with physiological stress of aging but only results

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A New Mouse Model of APOL1 -Associated Kidney Diseases: When Traffic Gets Snarled, the Podocyte Suffers

Cited by 2 publications

References 39 publications

Chronic kidney disease in African Americans: Puzzle pieces are falling into place

Chronic kidney disease in African Americans: Puzzle pieces are falling into place

Podocyte density is reduced in kidney allografts with high‐risk APOL1 genotypes at transplantation

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