Measuring in vivo cerebral maturation using age-related T 2 relaxation times at 3 T

Bültmann, Eva; Spineli, Loukia M.; Hartmann, Hans; Lanfermann, Heinrich

doi:10.1016/j.braindev.2017.07.011

Cited by 9 publications

(2 citation statements)

References 24 publications

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“…2d). 66 With echo‐planar imaging (EPI) spin‐echo sequences with different sequence parameters (several inversion times [TI] or echo times [TE]), T 1 and T 2 values could be computed over the whole brain of infants and with good spatial resolution 67 (Fig. 4a,b).…”

Section: Anatomical and Relaxometry Mrimentioning

confidence: 99%

MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances

Dubois

Alison

Counsell

et al. 2020

Magnetic Resonance Imaging

108

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In recent years, exploration of the developing brain has become a major focus for researchers and clinicians in an attempt to understand what allows children to acquire amazing and unique abilities, as well as the impact of early disruptions (eg, prematurity, neonatal insults) that can lead to a wide range of neurodevelopmental disorders. Noninvasive neuroimaging methods such as MRI are essential to establish links between the brain and behavioral changes in newborns and infants. In this review article, we aim to highlight recent and representative studies using the various techniques available: anatomical MRI, quantitative MRI (relaxometry, diffusion MRI), multiparametric approaches, and functional MRI. Today, protocols use 1.5 or 3T MRI scanners, and specialized methodologies have been put in place for data acquisition and processing to address the methodological challenges specific to this population, such as sensitivity to motion. MR sequences must be adapted to the brains of newborns and infants to obtain relevant good soft‐tissue contrast, given the small size of the cerebral structures and the incomplete maturation of tissues. The use of age‐specific image postprocessing tools is also essential, as signal and contrast differ from the adult brain. Appropriate methodologies then make it possible to explore multiple neurodevelopmental mechanisms in a precise way, and assess changes with age or differences between groups of subjects, particularly through large‐scale projects. Although MRI measurements only indirectly reflect the complex series of dynamic processes observed throughout development at the molecular and cellular levels, this technique can provide information on brain morphology, structural connectivity, microstructural properties of gray and white matter, and on the functional architecture. Finally, MRI measures related to clinical, behavioral, and electrophysiological markers have a key role to play from a diagnostic and prognostic perspective in the implementation of early interventions to avoid long‐term disabilities in children. Evidence Level 2 Technical Efficacy Stage 1

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Section: Anatomical and Relaxometry Mrimentioning

confidence: 99%

MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances

Dubois

Alison

Counsell

et al. 2020

Magnetic Resonance Imaging

108

View full text Add to dashboard Cite

show abstract

“…In the context of preterm newborns with imaging from birth to TEA, T1estimates illustrated a greater reduction with age in various areas of WM along with GM, inclusive of cortex in addition to central gray nuclei50,51]. Quantitative T2 times to be estimated gets aided byturbo/rapid spin echo sequences with multiple echoes ,whose reduction takes place persistently with escalation of age, in particular at the time of the first postnatal year (figure 2d) [52]. Spin echo sequences with various sequence parameter (various inversion timesor echo times(TE),computation of T1 awa T2 estimates over the total brain of infants in addition to greater resolution in space could get attained with the utilization of echo planar imaging(EPI) [53](figure4a,b).…”

Section: Studies In the Context Of Microstructurementioning

confidence: 99%

‘’An update on MRI of Brain of Neonates with its associated hurdles and Advancements for Analysis of Brain Morphology, Structural, Functional Connectivity and Functional Architecture for avoidance of Neuro developmental Diseases’’ -A Systematic Revie

Kaur¹

2022

JPPR

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What is the method by which the generation of unbelievable cognitive capacity in addition to its working with the utilization of intellect.?What is the reason for5-10% adults for the generation of neurodevelopmental diseases or conditions like autism or dyslexia?For receipt of answers to these queries needs a greater insight in the context of the way human brain formation takes place in early stages . Studies with regards to models have not been adequate in view of variability of human species generation in contrast to other mammals in view of short time period of pregnancy in contrast to the duration amongst birth along with early adult period. Despite the brain of the newborn possesses an early along with comparative organization it being immature contributes to the postnatal modeling secondary to numerous experiences along with learning which the newborn infant’s exposure takes place. Furthermore the generating brain demonstrate a great plasticity subsequent to getting disrupted specifically with regards to the networks whose maturity takes place late at the time of childhood.

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Cerebral microstructural changes in children suffering from hemolytic uremic syndrome

et al. 2023

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To evaluate microstructural cerebral changes in children suffering from typical hemolytic uremic syndrome (HUS) based on apparent diffusion coefficient (ADC) maps. For 12 pediatric HUS patients (0.8 - 14.6 years of age) conventional magnetic resonance imaging (cMRI) at 1.5 T was retrospectively analyzed. ADC values were measured in 35 different brain regions and compared with age-related, previously published ADC reference values from a healthy pediatric control group. The HUS cohort was divided into 2 subgroups depending on clinical outcome. Subgroup A showed poor neurological outcome whereas subgroup B demonstrated improvement without lasting neurological deficits. Qualitative analysis revealed lesions by diffusion-weighted imaging (DWI) with hypointense correlate on the ADC map in basal ganglia and/or thalami and corresponding T2 hyperintensities in the majority of patients in Subgroup A (80%). Those in Subgroup B did not show qualitative DWI alterations with ADC correlate even when T2 hyperintense lesions were detected in basal ganglia and/or thalami. Quantitative analysis demonstrated abnormal ADC values in all HUS patients with a trend to a greater number of affected regions in Subgroup A compared to Subgroup B (16 versus 11 median number of regions respectively, p = 0.56). Conclusion: Using DWI qualitative and quantitative differences were found between HUS patients showing poor neurological outcome and those without neurological deficits at discharge. While ADC values indicated more extensive cerebral changes than conventional qualitative findings, both may provide early prognostic indicators for neurological outcome in pediatric HUS patients. What is Known:• In patients with STEC-HUS and neurological symptoms, MRI may show hyperintense signals on T2 and altered diffusivity mostly affecting basal ganglia, thalami and periventricular white matter. What is New:• In such patients, early MRI including quantitative ADC measurements over different brain regions may allow for detection of signal alterations possibly reflecting microstructural changes in such patients.

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Measuring in vivo cerebral maturation using age-related T 2 relaxation times at 3 T

Cited by 9 publications

References 24 publications

MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances

MRI of the Neonatal Brain: A Review of Methodological Challenges and Neuroscientific Advances

‘’An update on MRI of Brain of Neonates with its associated hurdles and Advancements for Analysis of Brain Morphology, Structural, Functional Connectivity and Functional Architecture for avoidance of Neuro developmental Diseases’’ -A Systematic Revie

Cerebral microstructural changes in children suffering from hemolytic uremic syndrome

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