1988
DOI: 10.1016/0268-9499(88)90635-2
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288 Residual plasminogen activator inhibitor activity after venous stasis as a criterium for hypofibrinolysis: A study in 83 patients with confirmed deep vein thrombosis

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Cited by 7 publications
(9 citation statements)
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“…Dynamic tests like venous occlusion test or stimula tion with desmopressin better reflect the fi brinolytic potential in vivo than firbinolytic parameters under basal conditions [5,6], Coronary artery thrombosis is believed to play a major role in the pathogenesis of actue myocardial infarction [7], sudden cardiac death [8], and unstable angina [9]. There fore, much interest has been recently paid to the evaluation of coagulation and fibrino lytic systems in coronary artery disease.…”
Section: Introductionmentioning
confidence: 99%
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“…Dynamic tests like venous occlusion test or stimula tion with desmopressin better reflect the fi brinolytic potential in vivo than firbinolytic parameters under basal conditions [5,6], Coronary artery thrombosis is believed to play a major role in the pathogenesis of actue myocardial infarction [7], sudden cardiac death [8], and unstable angina [9]. There fore, much interest has been recently paid to the evaluation of coagulation and fibrino lytic systems in coronary artery disease.…”
Section: Introductionmentioning
confidence: 99%
“…Activation of plasminogen by tissue plas minogen activator (t-PA), which is released from endothelial cells by various stimuli [1], is greatly enhanced in the presence of fibrin [2], Impaired fibrinolysis may result from decreased production and/or release of t-PA and from increased inhibition of t-PA by its specific inhibitor in plasma, named plasmin ogen activator inhibitor 1 (PAI-1) [3,4], As fibrinolytic abnormalities frequently cause venous thrombosis [4][5][6], their laboratory testing is of clinical importance. Dynamic tests like venous occlusion test or stimula tion with desmopressin better reflect the fi brinolytic potential in vivo than firbinolytic parameters under basal conditions [5,6], Coronary artery thrombosis is believed to play a major role in the pathogenesis of actue myocardial infarction [7], sudden cardiac death [8], and unstable angina [9].…”
Section: Introductionmentioning
confidence: 99%
“…After VO, decreased fibrinolytic activity was related to decreased plasma concentration of tPA antigen. Impaired fibrinolytic response to VO has been related to either a deficient release of tPA during VO or increased PAI-1 activity levels before VO (32,33). Because plasma concentrations of PAI-1 antigen and activity were similar in both populations, and no increased residual PAI-1 activity was present in patients relative to control subjects, impaired fibrinolytic response to VO in our patients likely reflects impaired release of tPA from the vascular endothelial cells, suggesting the presence of endothelial cell damage.…”
Section: Discussionmentioning
confidence: 80%
“…This became clear when assessing fibrinolysis after standard fibrinolytic stimulus. Assessment after a fibrinolytic stimulus is considered more informative than assessment under basal conditions [5,12,13]. The difference was that, unlike healthy individuals, hemodialysis diabetic patients did not show, after a stimulus, a significant fall in PAI-1 concentrations which thus remained higher than those in healthy individuals.…”
Section: Discussionmentioning
confidence: 91%