Intramuscular Perfusion Response in Delayed Onset Muscle Soreness (DOMS): A Quantitative Analysis with Contrast-Enhanced Ultrasound (CEUS)

Kellermann, Marion; Heiß, Rafael; Swoboda, B.; Gelse, Kolja; Freiwald, Jürgen; Grim, Casper; Nagel, Armin M.; Uder, Michael; Wildner, D; Hotfiel, Thilo

doi:10.1055/s-0043-112501

Cited by 26 publications

(18 citation statements)

References 41 publications

(55 reference statements)

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“…Additionally, the released cytokines lead to a higher vascular permeability and microcirculation disturbances as they act as inflammatory mediators [35]. A recent study investigating intramuscular tissue perfusion by quantifiable contrast-enhanced ultrasound in DOMS demonstrated statistically significant increases in intramuscular perfusion 60 hours after exhausting eccentric exercise of the gastrocnemius muscle [36]. Affected muscle tissue is invaded by neutrophils several hours after eccentric exercise and replaced by macrophages [18,37].…”

Section: Inflammatory and Healing Responsesmentioning

confidence: 99%

Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics

Hotfiel

Freiwald

Hoppe

et al. 2018

Sportverletz Sportschaden

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116

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Delayed-onset muscle soreness (DOMS) is a type of ultrastructural muscle injury. The manifestation of DOMS is caused by eccentric or unfamiliar forms of exercise. Clinical signs include reduced force capacities, increased painful restriction of movement, stiffness, swelling, and dysfunction of adjacent joints. Although DOMS is considered a mild type of injury, it is one of the most common reasons for compromised sportive performance. In the past few decades, many hypotheses have been developed to explain the aetiology of DOMS. Although the exact pathophysiological pathway remains unknown, the primary mechanism is currently considered to be the ultrastructural damage of muscle cells due to unfamiliar sporting activities or eccentric exercise, which leads to further protein degradation, apoptosis and local inflammatory response. The development of clinical symptoms is typically delayed (peak soreness at 48 – 72 h post-exercise) as a result of complex sequences of local and systemic physiological responses. The following narrative review was conducted to present an overview of the current findings regarding the damaging mechanisms as well as the pathophysiology of DOMS and its diagnostic evaluation.

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Section: Inflammatory and Healing Responsesmentioning

confidence: 99%

Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics

Hotfiel

Freiwald

Hoppe

et al. 2018

Sportverletz Sportschaden

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116

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“…Regarding the influence of post-exercise CWI on muscle stiffness, the efficiency seems to be dependent on the type of the previous exercise. The application of post-exercise CWI is a commonly used therapy to enhance recovery, and thereby to counteract EIMD or DOMS [3,4,15,18,32,33]. Particularly in elite sports, CWI is recommended by many physical therapists and coaches [1].…”

Section: Discussionmentioning

confidence: 99%

Effects of Pre- and Post-Exercise Cold-Water Immersion Therapy on Passive Muscle Stiffness

Hüttel

Golditz

Mayer

et al. 2019

Sportverletz Sportschaden

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Background Cold-water immersion (CWI) has become a popular preventive, regenerative and performance-enhancing intervention in various sports. However, its effects on soft tissue, including changes of intramuscular stiffness, are poorly understood. The purpose of this study was to investigate the effect of CWI on muscle stiffness. Patients/Material and Methods Thirty healthy participants were included and divided into the three following groups (n = 10): 1) post-ESU group: exercise and CWI (post-exercise set-up); 2) control group: exercise without CWI (control condition); 3) pre-ESU group: CWI alone (pre-exercise set-up). Acoustic radiation force impulse (ARFI) elastography was conducted to assess tissue stiffness (shear wave velocity, SWV). Values obtained at resting conditions (baseline, t0) were compared to values post-exercise (t1, for post-ESU group and control group), post-CWI (t2, for post-ESU group and pre-ESU group; rest for control group) and to 60-min follow-up time (t3, for all groups). Data were assessed in superficial and deep muscle tissue (rectus femoris muscle, RF; vastus intermedius muscle, VI). Results For the post-ESU group (CWI post-exercise), there was no significant difference between the time points of measurements: exercise (t1: RF: 1.63 m/s; VI: 1.54 m/s), CWI (t2: RF: 1.63 m/s; VI: 1.53 m/s) and at 60-min follow-up (t3: RF: 1.72 m/s; VI: 1.61 m/s). In the control group, a significant decrease of SWV was found between baseline conditions at t0 and post-exercise (t1) at VI (VI: 1.37 m/s; p = 0.004; RF: 1.59 m/s; p = 0.084). For t2 and t3, no further significant changes were detected. Regarding the pre-exercise set-up (pre-ESU group), a significant decrease in SWV from baseline to t2 in VI (1.60 m/s to 1.49 m/s; VI: p = 0.027) was found. Conclusion This study shows varying influences of CWI on muscle stiffness. Overall, we did not detect any significant effects of CWI on muscle stiffness post-exercise. Muscle stiffness-related effects of CWI differ in the context of a pre- or post-exercise condition and have to be considered in the implementation of CWI to ensure its potential preventive and regenerative benefits.

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“…DOMS is often accompanied by impaired muscle contraction and reduced force capacity [17,19,20], whilst a local or even global area of increased muscle tone is commonly observed [21,22,23,24]. DOMS is associated with local muscle soreness, reduced range of motion and altered biomechanical function of the adjacent joints [17,19,20,25,26]. Although the precise underlying causes of DOMS remain unknown [27], it is commonly accepted that the main mechanisms are related to ultrastructural damage of skeletal muscle integrity (exercise-induced muscle damage, EIMD) caused by intense and exhausting exercise and/or unfamiliar sporting activity [28,29,30] (Figure 2, Figure 3); for elite triathletes, the first scenario being the most relevant.…”

Section: Resultsmentioning

confidence: 99%

Accelerating Recovery from Exercise-Induced Muscle Injuries in Triathletes: Considerations for Olympic Distance Races

Hotfiel

Mayer

Huettel

et al. 2019

Sports

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The triathlon is one of the fastest developing sports in the world due to expanding participation and media attention. The fundamental change in Olympic triathlon races from a single to a multistart event is highly demanding in terms of recovery from and prevention of exercise-induced muscle injures. In elite and competitive sports, ultrastructural muscle injuries, including delayed onset muscle soreness (DOMS), are responsible for impaired muscle performance capacities. Prevention and treatment of these conditions have become key in regaining muscular performance levels and to guarantee performance and economy of motion in swimming, cycling and running. The aim of this review is to provide an overview of the current findings on the pathophysiology, as well as treatment and prevention of, these conditions in compliance with clinical implications for elite triathletes. In the context of DOMS, the majority of recovery interventions have focused on different protocols of compression, cold or heat therapy, active regeneration, nutritional interventions, or sleep. The authors agree that there is a compelling need for further studies, including high-quality randomized trials, to completely evaluate the effectiveness of existing therapeutic approaches, particularly in triathletes. The given recommendations must be updated and adjusted, as further evidence emerges.

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Intramuscular Perfusion Response in Delayed Onset Muscle Soreness (DOMS): A Quantitative Analysis with Contrast-Enhanced Ultrasound (CEUS)

Cited by 26 publications

References 41 publications

Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics

Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics

Effects of Pre- and Post-Exercise Cold-Water Immersion Therapy on Passive Muscle Stiffness

Accelerating Recovery from Exercise-Induced Muscle Injuries in Triathletes: Considerations for Olympic Distance Races

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