Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea

Lee, Kyung Hwa; Seo, Sang Won; Lim, Tae Sung; Kim, Eun Joo; Kim, Byeong C.; Kim, Yeshin; Lee, Ho Won; Jeon, Jae‐Pil; Shim, Sung Mi; Na, Duk L.; Huh, Gi Yeong; Lee, Min Cheol; Suh, Yeon Lim

doi:10.3349/ymj.2017.58.5.1055

Cited by 12 publications

(8 citation statements)

References 18 publications

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“…Neuropathological analysis was performed at Chuncheon Sacred Heart Hospital, Chuncheon, Korea. Autopsies were performed according to the standard protocols of National Neuropathology Reference and Diagnostic Laboratories for Dementia (NRD) supported by Korea National Institute of Health [10, 11]. Neuropathological diagnostic analysis was performed on sections, including the frontal, occipital, and basal ganglia of the right and left hemisphere.…”

Section: Case Presentationmentioning

confidence: 99%

THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report

et al. 2019

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Background THK5351 and flortaucipir tau ligands have high affinity for paired helical filament tau, yet diverse off-target bindings have been reported. Recent data support the hypothesis that THK5351 binds to monoamine oxidase B (MAO-B) expressed from reactive astrocytes and that flortaucipir has an affinity toward MAO-A and B; however, pathological evidence is lacking. We performed a head-to-head comparison of the two tau ligands in a sporadic Creutzfeldt-Jakob disease (CJD) patient and performed an imaging-pathological correlation study. Case presentation A 67-year-old man visited our clinic a history of 6 months of rapidly progressive dementia, visual disturbance, and akinetic mutism. Diffusion-weighted imaging showed cortical diffusion restrictions in the left temporo-parieto-occipital regions. 18 F-THK5351 PET, but not 18 F-flortaucipir PET showed high uptake in the left temporo-parieto-occipital regions, largely overlapping with the diffusion restricted areas. Cerebrospinal fluid analysis was weakly positive for 14–3-3 protein and pathogenic prion protein was found. The patient showed rapid cognitive decline along with myoclonic seizures and died 13 months after his first visit. A post-mortem study revealed immunoreactivity for PrP sc , no evidence of neurofibrillary tangles, and abundant astrocytosis which was reactive for MAO-B antibody. Conclusions Our findings add pathological evidence that increased THK5351 uptake in sporadic CJD patients might be caused by an off-target binding driven by its high affinity for MAO-B. Electronic supplementary material The online version of this article (10.1186/s12883-019-1434-z) contains supplementary material, which is available to authorized users.

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Section: Case Presentationmentioning

confidence: 99%

THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report

et al. 2019

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“…9 To prevent under-recognition of LATE-NC during brain autopsy, it is critical to perform TDP-43 immunohistochemistry on three anatomical sections, as proposed previously. 10 The prevalence of LATE-NC increases gradually with age, while that of severe ADNC decreases. 11 Consequently, LATE plays a pivotal role in amnestic-type cognitive impairment among the rapidly growing oldest old population.…”

Section: Discussionmentioning

confidence: 97%

An Autopsy-Proven Case of Limbic-Predominant Age-Related TDP-43 Encephalopathy

et al. 2020

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Limbic-predominant age-related TDP-43 encephalopathy (LATE) is a recently established neurodegenerative disease entity. LATE neuropathological change (LATE-NC) is characterized by a TDP-43 proteinopathy that mainly involves the amygdala and medial temporal structures, with or without hippocampal sclerosis. LATE-NC is typically observed in individuals aged 80 years or older and manifests clinically as amnestic memory decline. Herein, we report a case of LATE diagnosed by brain autopsy in an 82-year-old male who had an 11-year history of memory impairment. Pathological examination revealed high Alzheimer disease neuropathological changes, as well as amygdala-predominant Lewy body pathology. In addition, immunohistochemistry for TDP-43 revealed neuronal and glial cytoplasmic inclusions in the dentate gyrus of the hippocampus, amygdala, and inferior temporal cortex. Increasing awareness of the newly defined entity LATE will enhance our understanding of the neurodegenerative processes that occur in the oldest individuals.

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“…We followed the guidelines for standardized operating procedures for brain autopsy, which was provided by the NRD. 8 Brain autopsies were performed at Samsung Medical Center (n=9), Jeju National University Hospital (n=1), and Ilsong Institute of Life Science, Hallym University (n=1). The autopsy of the Creutzfeldt-Jakob disease (CJD) patient was undertaken at the Korea CJD Diagnostic Center (Ilsong Institute of Life Science, Hallym University).…”

Section: Methodsmentioning

confidence: 99%

“…Pathological assessments were performed using institution-specific protocols rendered at consensus conferences, as previously described. 8 All autopsies included tissue sampling in regions relevant to the differential diagnosis of dementia based on published consensus criteria. 9 10 11 12 13 14 Tissue staining included some combination of hematoxylin/eosin, silver staining with modified Bielschowsky or Gallyas methods, and immunohistochemistry for Aβ, hyperphosphorylated tau, α-synuclein, ubiquitin, and transactive response DNA binding protein 43 (TDP-43).…”

Section: Methodsmentioning

confidence: 99%

The Brain Donation Program in South Korea

et al. 2018

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PurposeObtaining brain tissue is critical to definite diagnosis and to furthering understanding of neurodegenerative diseases. The present authors have maintained the National Neuropathology Reference and Diagnostic Laboratories for Dementia in South Korea since 2016. We have built a nationwide brain bank network and are collecting brain tissues from patients with neurodegenerative diseases. We are aiming to facilitate analyses of clinic-pathological and image-pathological correlations of neurodegenerative disease and to broaden understanding thereof.Materials and MethodsWe recruited participants through two routes: from memory clinics and the community. As a baseline evaluation, clinical interviews, a neurological examination, laboratory tests, neuropsychological tests, and MRI were undertaken. Some patients also underwent amyloid PET.ResultsWe recruited 105 participants, 70 from clinics and 35 from the community. Among them, 11 died and were autopsied. The clinical diagnoses of the autopsied patients included four with Alzheimer's disease (AD), two with subcortical vascular dementia, two with non-fluent variant primary progressive aphasia, one with leukoencephalopathy, one with frontotemporal dementia (FTD), and one with Creutzfeldt-Jakob disease (CJD). Five patients underwent amyloid PET: two with AD, one with mixed dementia, one with FTD, and one with CJD.ConclusionThe clinical and neuropathological information to be obtained from this cohort in the future will provide a deeper understanding of the neuropathological mechanisms of cognitive impairment in Asia, especially Korea.

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Proposal Guidelines for Standardized Operating Procedures of Brain Autopsy: Brain Bank in South Korea

Cited by 12 publications

References 18 publications

THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report

THK5351 and flortaucipir PET with pathological correlation in a Creutzfeldt-Jakob disease patient: a case report

An Autopsy-Proven Case of Limbic-Predominant Age-Related TDP-43 Encephalopathy

The Brain Donation Program in South Korea

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