Plasma fibrinogen and serum albumin levels (FA score) act as a promising prognostic indicator in non-small cell lung cancer

Chen, Pengxiang; Cheng, Bo; Nesa, Effat Un; Liu, Yuan; Jia, Yibin; Qü, Yan; Jiang, Ziying; Han, Jie; Cheng, Yufeng

doi:10.2147/ott.s138854

Cited by 23 publications

(28 citation statements)

References 43 publications

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“…In addition to our analysis, recent studies also indicated a positive correlation between elevated plasma fibrinogen levels and poorer prognosis in other solid tumors including esophageal carcinoma, 37 – 39 small cell lung carcinoma, 40 non-small cell lung carcinoma, 41 upper urinary tract urothelial carcinoma, 42 , 43 epithelial ovarian cancer, 44 colorectal cancer, 45 renal cell carcinoma, 46 , 47 and gastric cancer. 48 , 49 There are several theories that may explain this association: 1) tumor progression is usually coupled with elevated inflammatory responses and leukocyte infiltration into tumor stroma.…”

Section: Discussionsupporting

confidence: 65%

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Huang¹,

Jiang²,

Lin³

et al. 2018

CMAR

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BackgroundElevated plasma fibrinogen levels have been associated with tumor progression in several malignancies. Our study aims to characterize the clinical significance of elevated plasma fibrinogen levels in patients with hepatocellular carcinoma (HCC).Materials and methodsRelevant published articles were systematically searched in electronic databases including PubMed, Embase, and Web of Science. The pooled differences in plasma fibrinogen levels among HCC, cirrhotic, and control groups were expressed as weighted mean differences (WMDs) and their corresponding 95% CIs. The associations between elevated fibrinogen and overall survival (OS) and disease-free survival (DFS)/recurrence-free survival (RFS) were expressed as HRs and their 95% CIs, whereas the associations between elevated fibrinogen and various types of clinical characteristic of patients with HCC were expressed as ORs and their corresponding 95% CIs.ResultsResults showed that the plasma fibrinogen levels in patients with HCC were not significantly different than that in healthy controls (WMD = 0.50, 95% CI = [−0.82, 1.82], P = 0.457) or patients with cirrhosis (WMD = −0.62, 95% CI = [−1.56, 0.33], P = 0.200). However, our results showed that compared to those with normal levels, patients with HCC and elevated plasma fibrinogen levels showed poorer OS (HR = 2.08, 95% CI = [1.67, 2.59], P < 0.0001) and DFS/RFS (HR = 1.90, 95% CI = [1.52, 2.37], P < 0.0001). Results of trial sequential analysis of the OS indicated that currently available studies were sufficient to validate the negative prognostic value of elevated plasma fibrinogen in patients with HCC. Clinicopathological analyses showed that high plasma fibrinogen levels were associated with tumor progression as indicated by advanced tumor stage, larger tumor size, increased tumor number, and the presence of vascular invasion.ConclusionElevated plasma fibrinogen levels are associated with poor prognosis and advanced tumor progression. Plasma fibrinogen may serve as a negative prognostic biomarker in patients with HCC.

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Section: Discussionsupporting

confidence: 65%

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Huang¹,

Jiang²,

Lin³

et al. 2018

CMAR

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“…Serum albumin is an important prognostic factor for survival of patients with NSCLC 19–21 . Some new indeices based on albumin have been reported for predicting the survival of patients with lung cancer, such indices include prognostic nutritional index 22 , Glasgow prognostic score 23 , fibrinogen and albumin score 24 , albumin and neutrophil combined prognostic grade 25 , and albumin-to-fibrinogen ratio 26 . If CRP and albumin can predict the survival of patients with NSCLC, then their combination may better predict the outcome than the use of CRP or albumin alone.…”

Section: Introductionmentioning

confidence: 99%

Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study

Yang

Chen

et al. 2019

Sci Rep

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Non-small cell lung cancer (NSCLC) is the most commonly diagnosed lung cancer and is associated with poor prognosis. This study aimed to analyze if serum C-reactive protein (CRP), albumin (Alb), and CRP/Alb ratio could provide prognostic information in patients with NSCLC. 387 patients with primary NSCLC were included in this analysis. Cox proportional hazards regression was used to estimate hazard ratio (HR) and 95% confidence interval (CI) of death with adjustment for some potential confounders. The multivariate regression analyses revealed the statistically significant associations of decreased survival of patients with NSCLC with elevated CRP, decreased Alb, and elevated CRP/Alb ratio. The HRs of mortality were 1.56 (95% CI: 0.80–3.04) and 2.64 (95% CI: 1.35–5.16) for patients in the second and the highest tertiles of CRP ( P -trend = 0.003). For albumin, the HR was 0.50 (95% CI: 0.29–0.85) for the normal group. The CRP/Alb ratio strongly predicted the survival of patients in the highest tertile with a fourfold risk of dying compared with those in the lowest tertile (HR = 4.14, 95% CI: 2.15–7.98). The subgroup analysis according to various patient characteristics confirmed these associations. In conclusion, serum CRP, albumin, and CRP/Alb ratio are predictive of survival for Chinese patients with NSCLC.

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“…Hyperfibrinogenemia can exist in many patients with malignant tumors including NSCLC and SCLC, which suggests a poor prognosis. [4,5,7,10,19] Fbg, synthesized by liver, is the highest content of coagulation proteins in plasma and can be converted to fiber polymer (insoluble fibrin) by activated thrombin. It plays a vital role in blood coagulation, fibrinolysis, inflammatory response, wound healing, and tumorigenesis.…”

Section: Discussionmentioning

confidence: 99%

“…[4,22] Therefore, in our research and early studies, we found the later the N, M, and CS were, the higher the average levels of plasma Fbg were. [19]…”

Section: Discussionmentioning

confidence: 99%

The relationship of plasma fibrinogen with clinicopathological stages and tumor markers in patients with non-small cell lung cancer

Bian¹,

Shi

Qi³

et al. 2019

Medicine

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Numerous studies have shown that the blood of cancer patients are generally in hypercoagulable statement. The aim of the present research is to study the relationships of plasma fibrinogen (Fbg) levels with clinicopathological stages (CS) and tumor markers of non-small cell lung cancer (NSCLC). Baseline information, plasma Fbg levels, CS, and expression level of tumor markers were collected from medical records retrospectively. Unitary linear regression was used to analyze the relationships between continuous variables and Fbg, and multiple linear regression was used to analyze the relationships between categorical variables and Fbg. National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology (Version 4) for NSCLC were adopted to evaluate CS. A total of 652 NSCLC patients were included. Compared with the females, male patients had higher mean plasma Fbg levels ( P < .001). The later the N stages ( P = .002), M stages ( P = .002), and CS ( P = .001) were, the higher the average plasma Fbg levels were. The levels of squamous cell carcinoma antigen ( P = .001), carbohydrate antigen 125 ( P = .041), and neuron-specific enolase ( P < .001) were positively correlated with plasma Fbg concentration. The plasma level of Fbg in lung adenocarcinoma patients ( P < .001) was the lowest, while that of lung squamous cell carcinoma patients ( P < .001) was the highest in NSCLC patients. The plasma Fbg concentration is related to gender, CS, and tumor markers in patients with NSCLC.

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Plasma fibrinogen and serum albumin levels (FA score) act as a promising prognostic indicator in non-small cell lung cancer

Cited by 23 publications

References 43 publications

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Prognostic value of plasma fibrinogen in hepatocellular carcinoma: a meta-analysis

Post-diagnostic C-reactive protein and albumin predict survival in Chinese patients with non-small cell lung cancer: a prospective cohort study

The relationship of plasma fibrinogen with clinicopathological stages and tumor markers in patients with non-small cell lung cancer

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