Global loss of myelin water over 5 years in multiple sclerosis normal-appearing white matter

Vavasour, Irene M.; Huijskens, Sophie C.; Li, David Kb; Traboulsee, Anthony; Mädler, Burkhard; Kolind, Shannon; Rauscher, Alexander; Moore, GR Wayne; MacKay, Alex L.; Laule, Cornelia

doi:10.1177/1352458517723717

Cited by 34 publications

(52 citation statements)

References 60 publications

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“…Ten participants [eight females and two males; mean age ± standard deviation (SD) = 57.1 ± 18.0 years; range, 24.7–80.3 years] with MS were scanned on a 3T Tim Trio MRI system (Siemens Healthcare, Erlangen, Germany) with a 32‐channel, receive‐only head coil; and, although the aims of this study were not related to MS per se , it was expected that patients with MS would yield a wider range of quantitative T 1 w/ T 2 w ratios and MWFs than a population comprised solely of young, neurologically‐healthy controls – providing a wider dynamic range for subsequent comparisons between methods. All participants with MS were diagnosed by a board‐certified neurologist on the basis of the revised McDonald criteria .…”

Section: Methodsmentioning

confidence: 99%

Can T₁w/T₂w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T₁w/T₂w ratios, GRASE‐based T₁w/T₂w ratios and multi‐echo GRASE‐based myelin water fractions

et al. 2018

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Given the growing popularity of T -weighted/T -weighted (T w/T w) ratio measurements, the objective of the current study was to evaluate the concordance between T w/T w ratios obtained using conventional fast spin echo (FSE) versus combined gradient and spin echo (GRASE) sequences for T w image acquisition, and to compare the resulting T w/T w ratios with histologically validated myelin water fraction (MWF) measurements in several subcortical brain structures. In order to compare these measurements across a relatively wide range of myelin concentrations, whole-brain T w magnetization prepared rapid acquisition gradient echo (MPRAGE), T w FSE and three-dimensional multi-echo GRASE data were acquired from 10 participants with multiple sclerosis at 3 T. Then, after high-dimensional, non-linear warping, region of interest (ROI) analyses were performed to compare T w/T w ratios and MWF estimates (across participants and brain regions) in 11 bilateral white matter (WM) and four bilateral subcortical grey matter (SGM) structures extracted from the JHU_MNI_SS 'Eve' atlas. Although the GRASE sequence systematically underestimated T w/T w values compared to the FSE sequence (revealed by Bland-Altman and mountain plots), linear regressions across participants and ROIs revealed consistently high correlations between the two methods (r = 0.62 for all ROIs, r = 0.62 for WM structures and r = 0.73 for SGM structures). However, correlations between either FSE-based or GRASE-based T w/T w ratios and MWFs were extremely low in WM structures (FSE-based, r = 0.000020; GRASE-based, r = 0.0014), low across all ROIs (FSE-based, r = 0.053; GRASE-based, r = 0.029) and moderate in SGM structures (FSE-based, r = 0.20; GRASE-based, r = 0.17). Overall, our findings indicated a high degree of correlation (but not equivalence) between FSE-based and GRASE-based T w/T w ratios, and low correlations between T w/T w ratios and MWFs. This suggests that the two T w/T w ratio approaches measure similar facets of subcortical tissue microstructure, whereas T w/T w ratios and MWFs appear to be sensitized to different microstructural properties. On this basis, we conclude that multi-echo GRASE sequences can be used in future studies to efficiently elucidate both general (T w/T w ratio) and myelin-specific (MWF) tissue characteristics.

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Section: Methodsmentioning

confidence: 99%

Can T₁w/T₂w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T₁w/T₂w ratios, GRASE‐based T₁w/T₂w ratios and multi‐echo GRASE‐based myelin water fractions

et al. 2018

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“…Quantitative MR imaging has been used to study a number of CNS conditions, such as epilepsy, multiple sclerosis, and stroke . It has also been extensively used to evaluate diseases of other organ systems, such as the heart, liver, and musculoskeletal system .…”

Section: Introductionmentioning

confidence: 99%

Cerebral Gray and White Matter Involvement in Anorexia Nervosa Evaluated by T1, T2, and T2* Mapping

Boto

Incebacak

Regnaud

et al. 2019

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Changes in the brain composition of anorexics could potentially be expected, opening the door to new imaging approaches where quantitative and qualitative MRI have a role. Our purpose was to investigate anorexia‐related brain dehydration and myelin depletion by analyzing T1, T2, and T2* relaxation times of different brain structures in anorexics and controls. METHODS Thirty‐eight anorexic female patients (mean age, 26.2 years; age range, 16.2‐48.7 years; mean BMI, 14.5 kg/m2; BMI range, 10.0‐18.4 kg/m2) underwent brain MRI between August 2014 and August 2018. Controls were 16 healthy females (mean age, 28.0 years; age range, 22.3‐34.7 years; mean BMI, 20.9 kg/m2; BMI range, 18.4‐26.6 kg/m2). T1, T2, and T2* relaxation times were obtained for different brain structures in anorexics and controls as part of this retrospective case‐control study. RESULTS The T1 relaxation times of gray and white matter were significantly lower in anorexics (P = .009), whereas the T2 relaxation times of gray matter were higher (P < .001). There were no statistically significant differences in gray matter T2* relaxation times or in white matter T2 and T2* relaxation times between anorexics and controls. Occipital lobe gray matter showed the shortest T1, T2, and T2* relaxation times of all brain regions (P < .05). CONCLUSIONS T1 shortening in anorexics suggests both dehydration and myelin loss, whereas T2 prolongation points toward myelin loss (myelin water has lower T2), which seems to be less discernible in white matter. Shorter overall relaxation times in the most posterior regions of the brain suggest higher iron content.

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“…CNS abnormalities beyond obvious MS plaques are also well documented . The “normal‐appearing white matter” (NAWM) is a commonly described feature of white matter that appears normal on conventional MRI, but abnormalities can be detected using advanced MRI …”

Section: Introductionmentioning

confidence: 99%

Diffusely Abnormal White Matter, T₂ Burden of Disease, and Brain Volume in Relapsing‐Remitting Multiple Sclerosis

Vertinsky

Vavasour

et al. 2018

Journal of Neuroimaging

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BACKGROUND AND PURPOSE Multiple sclerosis (MS) diffusely abnormal white matter (DAWM) is a mildly hyperintense magnetic resonance imaging abnormality distinct from typical lesions. Our goal was to investigate the prevalence and natural history of DAWM in a large cohort (n = 348) of relapsing–remitting MS (RRMS) patients. METHODS The presence of DAWM and relationship to changes in T2 burden of disease (BOD), brain volume (brain fractional ratio, BFR), and disability (Expanded Disability Status Scale, EDSS) were investigated at baseline and year 7–8 (long‐term follow‐up, LTF). RESULTS DAWM was present in 25.3% (88 of 348) of patients at baseline. At LTF, DAWM was unchanged in 69.3% (61 of 88), decreased in 28.4% (25 of 88), and increased in 2.3% (2 of 88) of patients. Baseline BOD and change in BOD did not significantly differ between patients with and without DAWM. DAWM was associated with greater reduction in BFR at LTF (P = .038). DAWM and DAWM change did not predict EDSS or EDSS progression. CONCLUSIONS DAWM is present in a quarter of RRMS patients, and rarely increases or develops de novo. DAWM predicts brain atrophy but does not predict physical disability. Because of its posterior periventricular location, further investigation is warranted to evaluate its relationship to other measures of disability, including visual spatial processing and cognitive function.

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Global loss of myelin water over 5 years in multiple sclerosis normal-appearing white matter

Cited by 34 publications

References 60 publications

Can T₁w/T₂w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T₁w/T₂w ratios, GRASE‐based T₁w/T₂w ratios and multi‐echo GRASE‐based myelin water fractions

Can T₁w/T₂w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T₁w/T₂w ratios, GRASE‐based T₁w/T₂w ratios and multi‐echo GRASE‐based myelin water fractions

Cerebral Gray and White Matter Involvement in Anorexia Nervosa Evaluated by T1, T2, and T2* Mapping

Diffusely Abnormal White Matter, T₂ Burden of Disease, and Brain Volume in Relapsing‐Remitting Multiple Sclerosis

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Global loss of myelin water over 5 years in multiple sclerosis normal-appearing white matter

Cited by 34 publications

References 60 publications

Can T1w/T2w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T1w/T2w ratios, GRASE‐based T1w/T2w ratios and multi‐echo GRASE‐based myelin water fractions

Can T1w/T2w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T1w/T2w ratios, GRASE‐based T1w/T2w ratios and multi‐echo GRASE‐based myelin water fractions

Cerebral Gray and White Matter Involvement in Anorexia Nervosa Evaluated by T1, T2, and T2* Mapping

Diffusely Abnormal White Matter, T2 Burden of Disease, and Brain Volume in Relapsing‐Remitting Multiple Sclerosis

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Product

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Can T₁w/T₂w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T₁w/T₂w ratios, GRASE‐based T₁w/T₂w ratios and multi‐echo GRASE‐based myelin water fractions

Can T₁w/T₂w ratio be used as a myelin‐specific measure in subcortical structures? Comparisons between FSE‐based T₁w/T₂w ratios, GRASE‐based T₁w/T₂w ratios and multi‐echo GRASE‐based myelin water fractions

Diffusely Abnormal White Matter, T₂ Burden of Disease, and Brain Volume in Relapsing‐Remitting Multiple Sclerosis