White matter microstructure predicts longitudinal social cognitive outcomes after paediatric traumatic brain injury: a diffusion tensor imaging study

Ryan, Nicholas; Genc, Sila; Beauchamp, Miriam H.; Yeates, Keith Owen; Hearps, Stephen; Catroppa, Cathy; Anderson, Vicki; Silk, Tim

doi:10.1017/s0033291717002057

Cited by 39 publications

(37 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical data confirm that DTI is sensitive to time since injury ( 65 ), and an accumulation of evidence implicates resolution of cognitive-behavioral function with altered brain architecture after TBI. DTI measures magnitude and directionality of water diffusion in tissue, and may be a sensitive biomarker of evolving and sustained white matter injury ( 66 ). Clinical studies assessing white matter microstructural organization use the same commonly derived diffusion metrics including FA, MD, AD, and RD as investigated here, and confirm children and adolescents with chronic moderate-severe TBI have lower FA and/or higher MD in numerous white matter fiber bundles including the corpus callosum ( 66 – 71 ).…”

Section: Discussionmentioning

confidence: 99%

“…DTI measures magnitude and directionality of water diffusion in tissue, and may be a sensitive biomarker of evolving and sustained white matter injury ( 66 ). Clinical studies assessing white matter microstructural organization use the same commonly derived diffusion metrics including FA, MD, AD, and RD as investigated here, and confirm children and adolescents with chronic moderate-severe TBI have lower FA and/or higher MD in numerous white matter fiber bundles including the corpus callosum ( 66 – 71 ). Interestingly, MD may index several factors, including fiber density, myelination, and expansion of extracellular space ( 66 , 72 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats

et al. 2018

View full text Add to dashboard Cite

Survivors of infant traumatic brain injury (TBI) are prone to chronic neurological deficits that impose lifelong individual and societal burdens. Translation of novel interventions to clinical trials is hampered in part by the lack of truly representative preclinical tests of cognition and corresponding biomarkers of functional outcomes. To address this gap, the ability of a high-dose, extended, post-injury regimen of erythropoietin (EPO, 3000U/kg/dose × 6d) to prevent chronic cognitive and imaging deficits was tested in a postnatal day 12 (P12) controlled-cortical impact (CCI) model in rats, using touchscreen operant chambers and regional analysis of diffusion tensor imaging (DTI). Results indicate that EPO prevents functional injury and MRI injury after infant TBI. Specifically, subacute DTI at P30 revealed widespread microstructural damage that is prevented by EPO. Assessment of visual discrimination on a touchscreen operant chamber platform demonstrated that all groups can perform visual discrimination. However, CCI rats treated with vehicle failed to pass reversal learning, and perseverated, in contrast to sham and CCI-EPO rats. Chronic DTI at P90 showed EPO treatment prevented contralateral white matter and ipsilateral lateral prefrontal cortex damage. This DTI improvement correlated with cognitive performance. Taken together, extended EPO treatment restores executive function and prevents microstructural brain abnormalities in adult rats with cognitive deficits in a translational preclinical model of infant TBI. Sophisticated testing with touchscreen operant chambers and regional DTI analyses may expedite translation and effective yield of interventions from preclinical studies to clinical trials. Collectively, these data support the use of EPO in clinical trials for human infants with TBI.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The following ROIs were selected: Bilateral left posterior STS, fusiform gyrus, temporal pole, inferior frontal gyrus, TPJ, amygdala, as well as the dorsomedial PFC (dmPFC), the ventromedial PFC (vmPFC), the rostral ACC and the medial frontal pole. These brain regions have consistently been related to morphological abnormalities and to social difficulties following TBI (Ryan, Catroppa, Beare, et al, , ; Ryan et al, ; Ryan, Catroppa, Cooper, Beare, Ditchfield, Coleman, Silk, Crossley, Rogers, et al, ; Ryan, Catroppa, Godfrey, et al, ; Ryan et al, ; see Table for details on ROIs and MNI coordinates).…”

Section: Methodsmentioning

confidence: 99%

“…The following ROIs were selected: Bilateral left posterior STS, fusiform gyrus, temporal pole, inferior frontal gyrus, TPJ, amygdala, as well as the dorsomedial PFC (dmPFC), the ventromedial PFC (vmPFC), the rostral ACC and the medial frontal pole. These brain regions have consistently been related to morphological abnormalities and to social difficulties following TBI Ryan et al, 2017;Ryan, Catroppa, Cooper, Beare, Ditchfield, Coleman, Silk, Crossley, Rogers, et al, 2015;Ryan, Catroppa, Godfrey, et al, 2016;Ryan et al, 2018; see Table 1 for details on ROIs and MNI coordinates). At the second-level analysis, two-sample t-tests were performed to assess between-group differences in ROI-to-ROI functional connectivity for each ROI, controlling for age at rsfMRI acquisition, sex, SES, and total GM volume to account for the global presence of structural lesions.…”

Section: Roi-to-roi Resting-state Fmri Analysesmentioning

confidence: 99%

Altered resting‐state functional connectivity within the developing social brain after pediatric traumatic brain injury

Tuerk

Dégeilh

Catroppa

et al. 2019

Human Brain Mapping

View full text Add to dashboard Cite

Traumatic brain injury (TBI) in childhood and adolescence can interrupt expected development, compromise the integrity of the social brain network (SBN) and impact social skills. Yet, no study has investigated functional alterations of the SBN following pediatric TBI. This study explored functional connectivity within the SBN following TBI in two independent adolescent samples. First, 14 adolescents with mild complex, moderate or severe TBI and 16 typically developing controls (TDC) underwent resting-state functional magnetic resonance imaging 12-24 months post-injury.Region of interest analyses were conducted to compare the groups' functional connectivity using selected SBN seeds. Then, replicative analysis was performed in an independent sample of adolescents with similar characteristics (9 TBI, 9 TDC). Results were adjusted for age, sex, socioeconomic status and total gray matter volume, and corrected for multiple comparisons. Significant between-group differences were detected for functional connectivity in the dorsomedial prefrontal cortex and left fusiform gyrus, and between the left fusiform gyrus and left superior frontal gyrus, indicating positive functional connectivity for the TBI group (negative for TDC). The replication study revealed group differences in the same direction between the left superior frontal gyrus and right fusiform gyrus. This study indicates that pediatric TBI may alter functional connectivity of the social brain. Frontal-fusiform connectivity has previously been shown to support affect recognition and changes in the function of this network could relate to more effortful processing and broad social impairments.

show abstract

“…Concussion in young children has been tied to decreases in theory of mind, mutual engagement, conversational flow, and reading emotional cues that persisted up to 24 months post-injury. 21,[44][45][46] A recent study described group pragmatic intervention for adults with mTBI, 47 and there are numerous articles that cite changes in social participation, social success, and increased isolation. 5,8,[48][49][50][51] These changes have traditionally been attributed to psychological health needs such as increased depression or anxiety, which do impact social participation, though further exploration of social communication behaviors in terms of cognitive-linguistic function is warranted.…”

Section: Social Communicationmentioning

confidence: 99%

The Role of Speech-Language Pathology in an Interdisciplinary Care Model for Persistent Symptomatology of Mild Traumatic Brain Injury

Hardin

Kelly

2019

Semin Speech Lang

View full text Add to dashboard Cite

The Marcus Institute for Brain Health (MIBH) provides interdisciplinary care for adults struggling with persistent effects of mild traumatic brain injury and accompanying changes in behavioral health, with specific emphases on Veterans and retired elite athletes. The cognitive, physical, and behavioral symptoms associated with mild traumatic brain injury are interrelated, with neurobiopsychosocial modeling encompassing the factors related to recovery from a traumatic brain injury. The diffuse impacts of chronic concussive injuries require multiple clinical providers to address the breadth of symptoms, facilitating both interdisciplinary and transdisciplinary care models. By implementing integrated practice units, patients receive advanced medical care, imaging, speech-language pathology, physical therapy, behavioral health, neuropsychology, and clinical pharmacy for a cohesive diagnostic and intervention plan. Nationally, speech-language pathologists report challenges with best-practice options for concussion, particularly in the domain of assessment practices. At the MIBH, speech-language pathologists begin their assessment with a structured clinical interview that focuses on patients' needs and concerns. Evaluation modalities focus on hearing, communication, and functional cognition to guide therapeutic treatment planning. The intensive outpatient care program at MIBH incorporates both individual sessions targeting patient-centered goals and group care, where speech-language pathologists work transdisciplinarily to generalize care from all disciplines out into the community. Care practices for concussive injuries continue to evolve rapidly; speech-language pathology at the MIBH offers one such vision for excellence in clinical care.

show abstract

White matter microstructure predicts longitudinal social cognitive outcomes after paediatric traumatic brain injury: a diffusion tensor imaging study

Abstract: Abnormal microstructure within frontal-temporal, limbic and cerebro-cerebellar white matter may be a risk factor for long-term social difficulties observed in children with TBI. DTI may have potential to unlock early prognostic markers of long-term social outcomes.

Cited by 39 publications

References 88 publications

Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats

Extended Erythropoietin Treatment Prevents Chronic Executive Functional and Microstructural Deficits Following Early Severe Traumatic Brain Injury in Rats

Altered resting‐state functional connectivity within the developing social brain after pediatric traumatic brain injury

The Role of Speech-Language Pathology in an Interdisciplinary Care Model for Persistent Symptomatology of Mild Traumatic Brain Injury

Contact Info

Product

Resources

About