Muscle hypertrophy and pseudohypertrophy

Walters, Jon

doi:10.1136/practneurol-2017-001695

Cited by 25 publications

(30 citation statements)

References 35 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Indeed, with few exceptions, chronic neurogenic foot drop is expected to be associated with prominent denervation atrophy. The exception to this rule is the infrequent occurrence of neurogenic muscular hypertrophy, mostly described in chronic lumbosacral radiculopathy, spinal muscular atrophy, or neuromyotonia [11]. Muscle MRI in our patient showed very marked fatty infiltration with relative preservation of overall soft tissue circumference, which is more in keeping with muscular dystrophy.…”

Section: Discussioncontrasting

confidence: 41%

Myofibrillar Myopathy Mimicking Polyneuropathy

2020

View full text Add to dashboard Cite

A 76-year-old man with a 5-year history of gait difficulties was suspected to have length-dependent sensorimotor polyneuropathy. Electrodiagnostic results pointed to a foot drop of neurogenic etiology, except for the prominence of myotonic discharges on needle EMG. Tests for acquired and genetic causes of polyneuropathy were unrevealing. The patient's first-degree cousin, with a much different clinical phenotype had been diagnosed with myofibrillar myopathy. Our patient was eventually found to carry the same myotilin c.179C>T p.Ser60Phe mutation. Muscle MRI was helpful in delineating clinically unsuspected involvement of paraspinal and pelvi-femoral muscles, as well as showing marked myopathic fatty infiltration of distal leg muscles. The association of neuropathy and myopathy is a recognized feature of myofibrillar myopathy. In some patients with unexplained foot drop, whole-body muscle MRI and a dedicated genetic mutation testing strategy may help reveal a diagnosis of genetic myopathy.

show abstract

Section: Discussioncontrasting

confidence: 41%

Myofibrillar Myopathy Mimicking Polyneuropathy

2020

View full text Add to dashboard Cite

show abstract

“…Healthy muscles enlarge through exercise. However, there also exist patients who have muscle enlargement secondary to neuromuscular diseases [109]. Muscle atrophy always accompanies neurogenic disorders, but muscle enlargement, both hypertrophy and pseudohypertrophy, has also been found in neurogenic disorders [109].…”

Section: Ncrnas Muscle Injury Repair and Diseasesmentioning

confidence: 99%

Non-Coding RNA Regulates the Myogenesis of Skeletal Muscle Satellite Cells, Injury Repair and Diseases

Zhao

Chen

Lian

et al. 2019

Cells

View full text Add to dashboard Cite

Skeletal muscle myogenesis and injury-induced muscle regeneration contribute to muscle formation and maintenance. As myogenic stem cells, skeletal muscle satellite cells have the ability to proliferate, differentiate and self-renew, and are involved in muscle formation and muscle injury repair. Accumulating evidence suggests that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are widely involved in the regulation of gene expression during skeletal muscle myogenesis, and their abnormal expression is associated with a variety of muscle diseases. From the perspective of the molecular mechanism and mode of action of ncRNAs in myogenesis, this review aims to summarize the role of ncRNAs in skeletal muscle satellite cells’ myogenic differentiation and in muscle disease, and systematically analyze the mechanism of ncRNAs in skeletal muscle development. This work will systematically summarize the role of ncRNAs in myogenesis and provide reference targets for the treatment of various muscle diseases, such as muscle dystrophy, atrophy and aberrant hypertrophy.

show abstract

“…Både pseudohypertrofi og hypertrofi av leggmuskler har ved noen få anledninger blitt beskrevet ved spinal muskelatrofi (1,2). Pasienten er nå middelaldrende, og bildet demonstrerer at han har kraftige legger samt betydelig atrofi av lårmuskler.…”

unclassified

“…Hypertrofi og pseudohypertrofi av leggmuskler er kliniske tegn ved en rekke sykdommer, også arvelige nevromuskulaere tilstander (1). Leggmusklene fremstår som velutviklet sammenlignet med lårmusklene.…”

unclassified

See 1 more Smart Citation