The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study

Boyle, Veronica T.; Thorstensen, Eric B.; Thompson, John M. D.; McCowan, Lesley; Mitchell, Edwin A.; Godfrey, Keith M.; Poston, Lucilla; Wall, Clare; Murphy, Rinki; Cutfield, Wayne S.; Kenealy, Tim; Kenny, Louise C.; Baker, Philip N.

doi:10.1038/ijo.2017.182

Cited by 27 publications

(37 citation statements)

References 57 publications

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“…Our study, which evaluated maternal vitamin D status at 15 weeks of gestation, showed no association between vitamin D exposure and the incidence of asthma. Neither maternal 25(OH)D at 15 weeks' gestation ≥75 nmol/L (28% of mothers) nor cord 25(OH)D ≥50 nmol/L (20% of newborns) modified asthma risk at 5 years in our study, echoed by numerous other large‐scale unselected birth cohorts . Further, our analysis of maternal and cord status stratified by 25(OH)D concentrations of 75 and 50 nmol/L, respectively, did not show any association with asthma risk or any other atopic outcome.…”

Section: Discussioncontrasting

confidence: 76%

“…Recently published data from two large‐scale, unselected prospective birth cohort studies in New Zealand and the UK also showed no association between vitamin D status in early pregnancy and parental report of eczema at school age. However, Wegienka and colleagues have shown that maternal 25(OH)D, but not cord 25(OH)D, was inversely associated with eczema in a sample of 707 children in the United States.…”

Section: Discussionmentioning

confidence: 99%

“…Given these promising trial data, the mixed results from observational studies of intrauterine vitamin D status and atopic diseases in children, including food allergy, eczema, asthma and allergic rhinitis, are puzzling. Liu et al proposed that vitamin D may interact with or modify inherited risk in children with a high‐risk genotype, based on their report of a significant interaction between an IL‐4 gene polymorphism and vitamin D deficiency, where increased risk of food sensitisation was observed among children with CC/CT genotypes (OR = 1.79, 95% CI: 1.15‐2.77).…”

Section: Introductionmentioning

confidence: 99%

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Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease‐specific Cork BASELINE Birth Cohort Study

Hennessy

Hourihane

Malvisi

et al. 2018

Allergy

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Section: Discussioncontrasting

confidence: 76%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease‐specific Cork BASELINE Birth Cohort Study

Hennessy

Hourihane

Malvisi

et al. 2018

Allergy

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“…Some international scientific organizations recommend that pregnant women take supplemental doses of vitamin D, ranging from 600 to 1,000 UI daily doses [ 10 – 12 ]. However, the World Health Organization has not universally adopted this practice [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D plasma concentrations in pregnant women and their preterm newborns

Kassai

Cafeo

Affonso-Kaufman

et al. 2018

BMC Pregnancy Childbirth

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BackgroundVitamin D deficiency is a global public health issue. More than half of pregnant women are affected by vitamin D insufficiency/deficiency. Studies suggest an association between low vitamin D concentrations during pregnancy with intrauterine growth restriction and prematurity. This study aimed to describe the concentrations of 25(OH)D (25-hydroxyvitamin D) of mothers who delivered preterm newborns compared to women with full-term pregnancy deliveries, as well as to relate 25(OH)D blood concentrations of mothers with those of their newborns.MethodThis cross-sectional study was conducted with 66 mothers who had given birth to preterm babies and their preterm newborns (PTNB, < 32 weeks), and 92 women who had given birth at the full-term of their pregnancy and their newborns (FTNB). Data were collected on the characteristics of mothers (gestational age, diseases, and habits) and newborns (anthropometry and adequacy for gestational age). Ten milliliters of blood were drawn from the mothers and the umbilical cord of newborns at birth to identify the 25(OH)D, parathyroid hormone, calcium, phosphorus, and alkaline phosphatase concentrations.ResultsMothers in the PTNB group had significantly lower mean 25(OH)D blood levels (21.7 ± 10.8 ng/mL vs. 26.2 ± 9.8 ng/mL; p = 0.011) and were three times more likely to have insufficiency when compared to mothers in the FTNB group (OR = 2.993; 95%CI 1.02–8.74). Newborns in the PTNB group also had lower 25(OH)D concentrations compared to FTNB group (25.9 ± 13.9 ng/dL vs. 31.9 ± 12.3 ng/dL; p = 0.009). There was a directly proportional correlation between mother and newborn umbilical cord 25(OH)D concentrations in PTNB (r = 0.596; p < 0.001) and FTNB (r = 0.765; p < 0.001).ConclusionMothers who delivered preterm babies and their preterm newborns had lower 25(OH)D concentrations compared to women who had given birth at the full-term of their pregnancy. In both groups, 25(OH)D concentrations of the mothers correlated directly with those of the newborns, and this correlation was higher in the full-term birth group. Nevertheless, the recommended universal vitamin D supplementation in pregnant women to curb the risk of preterm birth is still incipient. More studies are required to clarify the particularities of vitamin D metabolism further and define the adequate 25(OH)D concentrations throughout pregnancy.

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“…With regard to specific nutrients, obese persons tend to have lower vitamin D levels 70 , and low maternal vitamin D levels during pregnancy are associated with higher risk of obesity in their offspring 71 . Conversely, vitamin D insufficiency has been associated with severe asthma exacerbations and worse asthma outcomes [72][73][74][75] .…”

Section: Respiratory Networkmentioning

confidence: 99%

The Challenge of Obesity and Asthma in Children and Adolescents

Forno¹,

Celedón²

2018

BRN

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Obesity and asthma each affect millions of people worldwide and the prevalence of both diseases has substantially risen in the last few decades. Solid epidemiological and experimental evidence strongly suggest that obesity increases asthma risk and severity, leading to growing recognition of an obese asthma phenotype. This phenotype is complex and multifactorial, differs between children and adults, and likely encompasses several sub-phenotypes. In this article, we will review the characteristics of obese asthma in children, as well as some of its underlying pathways. Furthermore, we will discuss some remaining challenges in the research, diagnosis, and management of obese asthma in children. (BRN Rev. 2018;4:70-83)

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The relationship between maternal 25-hydroxyvitamin D status in pregnancy and childhood adiposity and allergy: an observational study

Cited by 27 publications

References 57 publications

Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease‐specific Cork BASELINE Birth Cohort Study

Antenatal vitamin D exposure and childhood eczema, food allergy, asthma and allergic rhinitis at 2 and 5 years of age in the atopic disease‐specific Cork BASELINE Birth Cohort Study

Vitamin D plasma concentrations in pregnant women and their preterm newborns

The Challenge of Obesity and Asthma in Children and Adolescents

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