Does baseline depression increase the risk of unexplained and accidental falls in a cohort of community‐dwelling older people? Data from The Irish Longitudinal Study on Ageing (TILDA)

Briggs, Robert; Kennelly, Sean; Kenny, Rose Anne

doi:10.1002/gps.4770

Cited by 46 publications

(43 citation statements)

References 46 publications

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“…43 Prior studies have also identified an association between other conditions potentially caused by low BP and deficits in cerebral perfusion, including stoke, syncope, and unexplained falls. [44][45][46] aOH-30 did not predict depression. There were no significant differences between those with sOH-30 and aOH-30 in terms of age, sex, cardiovascular disease, or use of culprit medications.…”

Section: Discussionmentioning

confidence: 76%

Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression

et al. 2018

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There is an established cross-sectional association between orthostatic hypotension (OH) and late-life depression. The aim of this observational study was to clarify the longitudinal association between baseline symptomatic OH (sOH-30) and incident depression in a sample of >3000 older people without baseline depression (mean age: 62 years at baseline). This study was embedded within the Irish Longitudinal Study on Ageing using data from waves 1 to 3, collected between 2009 and 2014. At 2- and 4-year follow-up, a score ≥9 on the 8-item Center for Epidemiological Studies Depression Scale was used to define incident depression. sOH-30 was defined as a drop in systolic blood pressure ≥20 mm Hg or diastolic blood pressure ≥10 mm Hg at 30 seconds post-standing in conjunction with orthostatic symptoms, such as dizziness, using beat-to-beat measurements. Almost one fifth (proportion, 18%; 95% confidence interval [CI], 16-20) of the study sample had sOH-30. One tenth (proportion, 10%; 95% CI, 9-12) had incident depression. Participants with incident depression were twice as likely to have sOH-30 at baseline compared with those without incident depression (linear regression, 13% [95% CI, 8-19] versus 7% [95% CI, 6-8]). Weighted logistic regression models demonstrated that sOH-30 predicted incident depression with an odds ratio of 1.90 (95% CI, 1.15-3.15) after controlling for covariates, including subthreshold depression, hypotension, cognitive impairment, and antidepressant use. Asymptomatic OH at 30 seconds and initial OH did not predict depression. This study demonstrates that sOH-30 predicts incident depression in a population-representative sample of older people and may, therefore, represent a potentially modifiable risk factor for late-life depression.

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Section: Discussionmentioning

confidence: 76%

Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression

et al. 2018

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“…It should be noted that depressive symptoms and fall are both dynamic and under progressive processes. Previous studies indicated that fall can result in depressive symptoms, and in turn, depressive symptoms can lead to fall accidents, which can further cause many health problems [11–14]. Previous literature have studied the association between baseline depressive symptoms and subsequent fall accidents [11–15] in other populations; however, the research relating to the association between depressive symptoms and subsequent fall accidents for Chinese people aged 45 and over is lacking.…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies indicated that fall can result in depressive symptoms, and in turn, depressive symptoms can lead to fall accidents, which can further cause many health problems [11–14]. Previous literature have studied the association between baseline depressive symptoms and subsequent fall accidents [11–15] in other populations; however, the research relating to the association between depressive symptoms and subsequent fall accidents for Chinese people aged 45 and over is lacking. Since 30% of men and 43% of women in China were suffering from depressive symptoms [16], it is urgent and meaningful to investigate the association between depressive symptoms and fall accidents.…”

Section: Introductionmentioning

confidence: 99%

The association between depressive symptoms and fall accidents among middle-aged and elderly people in China

Ouyang

Sun

2018

Environ Health Prev Med

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BackgroundDepressive symptoms are a worldwide health problem. However, the research about the effect of depressive symptoms on the fall among the Chinese mid-aged and elderly people is lacking. Therefore, this study aims to investigate the association between depressive symptoms and fall accidents among middle-aged and elderly people in China.MethodsThis study was conducted based on 12,527 sets of data from China Health and Retirement Longitudinal Survey (CHARLS). The 2011 depressive symptoms data and the 2013 fall data were chosen for this study. The depressive symptom-related data was assessed by the Chinese version of Center for Epidemiologic Studies Depression scales (CES-D). Individuals were divided into subgroups according to gender (male or female), age (45–59, middle-aged or ≥ 60, elderly people), and residence (rural or urban). The odds ratios (ORs) were compared between subgroups using multivariable logistic regression analysis method.ResultsThe adjusted OR value (OR = 1.19 [95% CI 1.07–1.33]) shows there is a significant association between depressive symptoms and subsequent fall accidents. The ORs of the female, elderly people, rural, and urban subgroups are 1.31 (95% CI 1.11–1.55), 1.24 (95% CI 1.08–1.43), 1.17 (95% CI 1.02–1.33), and 1.25 (95% CI 1.04–1.49), respectively, which reveals that this association is also statistically significant in these subgroups.ConclusionsThis study shows that there is a significant association between depressive symptoms and their subsequent fall accidents among the Chinese middle-aged and elderly people.

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“…Late‐life depression is associated with an increased risk of falls, which may be related to gait disturbance . Importantly, cerebral white matter disease has also been shown to predict incidence of depression in later life, as well as poorer prognosis …”

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confidence: 99%

“…12 Late-life depression is associated with an increased risk of falls, which may be related to gait disturbance. 13 Importantly, cerebral white matter disease has also been shown to predict incidence of depression in later life, as well as poorer prognosis. 14 To date, most work examining gait patterns in late-life depression is cross-sectional and longitudinal studies have not yet examined the role of specific gait characteristics as markers of risk.…”

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confidence: 99%

Do Differences in Spatiotemporal Gait Parameters Predict the Risk of Developing Depression in Later Life?

Briggs

Carey

Claffey

et al. 2019

J American Geriatrics Society

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Background/Objectives There is growing interest in the association between gait disturbance and depression in later life. The aim of this study is to clarify the longitudinal relationship between specific gait parameters and incident depression within a population‐representative sample of older people. Design Longitudinal analysis of spatiotemporal gait parameters at baseline (wave 1) and incident depression at 2 and 4 years (waves 2/3). Logistic regression models were used to assess the relationship between tertiles of gait parameters and incident depression. Setting The Irish Longitudinal Study on Aging. Participants Over 3600 nondepressed community‐dwelling people aged 50 years or older. Measurements A score of 9 or greater on the eight‐item Center for Epidemiological Studies Depression Scale at wave 2 or 3 was indicative of incident depression. The GAITRite system was used to measure gait speed, step length, step width, and double support phase during usual speed walking and under dual task conditions. Results Participants with incident depression (344/3615) had slower gait speed (129.9 [95% confidence interval {CI} = 127.2‐132.6] cm/s vs 134.1 [95% CI = 133.0‐135.1] cm/s; F = 8.82; P = .003) and shorter step length (68.0 [95% CI = 66.9‐69.2] cm vs 70.3 [95% CI = 69.9‐70.7] cm; F = 13.99; P < .001) at baseline than those who did not develop depression. Logistic regression models demonstrated that those within the slowest tertile for gait speed and shortest tertile for step length had significantly increased likelihood of incident depression in fully adjusted models, with odds ratios of 1.54 (95% CI = 1.08‐2.19) and 1.54 (95% CI = 1.01‐2.35), respectively. Measures of step width and double support time were not associated with depression. Conclusions This study demonstrates that older people with incident depression have significantly slower gait speed and shorter step length at initial assessment. These findings are clinically significant given the impact both conditions have on functional status in later life, as well as the possibility that gait problems may represent a potentially modifiable risk factor for depression. J Am Geriatr Soc 67:1050–1056, 2019.

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Does baseline depression increase the risk of unexplained and accidental falls in a cohort of community‐dwelling older people? Data from The Irish Longitudinal Study on Ageing (TILDA)

Cited by 46 publications

References 46 publications

Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression

Longitudinal Association Between Orthostatic Hypotension at 30 Seconds Post-Standing and Late-Life Depression

The association between depressive symptoms and fall accidents among middle-aged and elderly people in China

Do Differences in Spatiotemporal Gait Parameters Predict the Risk of Developing Depression in Later Life?

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