Circulating soluble receptor for advanced glycation end product: Cross-sectional associations with cardiac markers and subclinical vascular disease in older men with and without diabetes

Wannamethee, SG; Welsh, Paul; Papacosta, Olia; Ellins, Elizabeth A; Halcox, Julian; Whincup, Peter H.; Sattar, Naveed

doi:10.1016/j.atherosclerosis.2017.07.008

Cited by 16 publications

(12 citation statements)

References 41 publications

(61 reference statements)

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“…These data seem to suggest that sRAGE and BNP could be related and could reflect the same outcome, but we cannot exclude that the lack of significance may be also due to a limited number of events observed in our population. Our hypothesis seems to be strongly supported by results obtained in other types of patients in which increasing sRAGE levels emerged as a marker of worsening heart function and mortality [ 31 – 35 ]. These studies, in fact, indicated the existence of an association between sRAGE and the severity of HF, whereby sRAGE levels are increased in patients with higher BNP levels.…”

Section: Discussionsupporting

confidence: 84%

Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients

Dozio

Ambrogi

Cal

et al. 2018

Mediators of Inflammation

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End-stage renal disease patients on dialysis (CKD-G5D) have a high mortality rate due to cardiovascular diseases (CVD). In these patients, inflammation, oxidative stress, and uremia increase the production of glycation products (AGEs) which in turn accelerate CVD onset and progression. Recently, attention has been given to the soluble receptor for AGEs (sRAGE) as a marker of inflammation, oxidative stress, atherosclerosis, and heart failure in CKD-G5D. However, its association with patient outcomes is still under debate. Our aim is to explore whether sRAGE may be a predictor of mortality in CKD-G5D. We studied 123 CKD-G5D for 24 months. Of these patients, 56 were on hemodialysis (HD) and 67 on peritoneal dialysis (PD). Demographic, anthropometric, biochemical, and clinical data were recorded. sRAGE was quantified by enzyme-linked immunosorbent assay. sRAGE was a predictor of mortality at 2-year follow-up. Each increase of 100 pg/mL in sRAGE levels was associated with an approximately 7% increased risk of mortality. Furthermore, in the entire study group, as well as in PD and HD patient subgroups, sRAGE was positively correlated with brain natriuretic peptide (BNP) levels. Mortality rates as well as sRAGE levels in patients who died did not differ between PD and HD patients. In conclusion, the positive association observed with BNP levels suggests a role for sRAGE as a prognostic factor for mortality in CKD-G5D patients displaying an active process of cardiac remodeling.

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Section: Discussionsupporting

confidence: 84%

Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients

Dozio

Ambrogi

Cal

et al. 2018

Mediators of Inflammation

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“…AGEs are formed when foods are processed at high temperatures such as deep-frying, grilling and roasting. They can increase oxidative stress, upregulate inflammation, and form cross-links with proteins [ 19 ], which cause impaired elasticity to blood vessels, therefore leading to poor heart health [ 20 , 21 ]. Upregulation of inflammation caused by AGEs has been also linked to cancer [ 22 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

The poly-omics of ageing through individual-based metabolic modelling

Yaneske

Angione

2018

BMC Bioinformatics

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BackgroundAgeing can be classified in two different ways, chronological ageing and biological ageing. While chronological age is a measure of the time that has passed since birth, biological (also known as transcriptomic) ageing is defined by how time and the environment affect an individual in comparison to other individuals of the same chronological age. Recent research studies have shown that transcriptomic age is associated with certain genes, and that each of those genes has an effect size. Using these effect sizes we can calculate the transcriptomic age of an individual from their age-associated gene expression levels. The limitation of this approach is that it does not consider how these changes in gene expression affect the metabolism of individuals and hence their observable cellular phenotype.ResultsWe propose a method based on poly-omic constraint-based models and machine learning in order to further the understanding of transcriptomic ageing. We use normalised CD4 T-cell gene expression data from peripheral blood mononuclear cells in 499 healthy individuals to create individual metabolic models. These models are then combined with a transcriptomic age predictor and chronological age to provide new insights into the differences between transcriptomic and chronological ageing. As a result, we propose a novel metabolic age predictor.ConclusionsWe show that our poly-omic predictors provide a more detailed analysis of transcriptomic ageing compared to gene-based approaches, and represent a basis for furthering our knowledge of the ageing mechanisms in human cells.Electronic supplementary materialThe online version of this article (10.1186/s12859-018-2383-z) contains supplementary material, which is available to authorized users.

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“…ER stress, for example, is coupled with the activation of MAP kinases [98]. Genes involved in inflammation are activated by certain transcription factors, including NF-κB, which has been phosphorylated by members of the MAPK family [99][100][101][102][103][104][105][106][107]. Another mechanism involved in the regulation of protein synthesis during ER stress concerns the phosphorylation of the subunit of eukaryotic initiation factor 2 (eIF2) which, in turn, involves the activation of NF-κB [108] and many cellular genes that are largely antiapoptotic under ER stress [109].…”

mentioning

confidence: 99%

“…Diabetic subjects, having high AGE content, are characterized by slow wound healing and high states of inflammation [110,111]. It is clear that ER stress activates multiple signal transduction pathways including eIF2α, MAPK, and NF-κB [99,111,112]. These pathways may be partly shared or converge on common downstream effectors [99,112].…”

mentioning

confidence: 99%

“…It is clear that ER stress activates multiple signal transduction pathways including eIF2α, MAPK, and NF-κB [99,111,112]. These pathways may be partly shared or converge on common downstream effectors [99,112]. For example, AGEs induce ER stress and stimulate the expression of Cox2 Oxidative Medicine and Cellular Longevity through the eIF2α, p38 MAPK, and NF-κB pathways in human chondrocytes [113].…”

mentioning

confidence: 99%

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Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects

Perrone

Giovino

Benny

et al. 2020

Oxidative Medicine and Cellular Longevity

276

219

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The advanced glycation end products (AGEs) are organic molecules formed in any living organisms with a great variety of structural and functional properties. They are considered organic markers of the glycation process. Due to their great heterogeneity, there is no specific test for their operational measurement. In this review, we have updated the most common chromatographic, colorimetric, spectroscopic, mass spectrometric, and serological methods, typically used for the determination of AGEs in biological samples. We have described their signaling and signal transduction mechanisms and cell epigenetic effects. Although mass spectrometric analysis is not widespread in the detection of AGEs at the clinical level, this technique is highly promising for the early diagnosis and therapeutics of diseases caused by AGEs. Protocols are available for high-resolution mass spectrometry of glycated proteins although they are characterized by complex machine management. Simpler procedures are available although much less precise than mass spectrometry. Among them, immunochemical tests are very common since they are able to detect AGEs in a simple and immediate way. In these years, new methodologies have been developed using an in vivo novel and noninvasive spectroscopic methods. These methods are based on the measurement of autofluorescence of AGEs. Another method consists of detecting AGEs in the human skin to detect chronic exposure, without the inconvenience of invasive methods. The aim of this review is to compare the different approaches of measuring AGEs at a clinical perspective due to their strict association with oxidative stress and inflammation.

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Circulating soluble receptor for advanced glycation end product: Cross-sectional associations with cardiac markers and subclinical vascular disease in older men with and without diabetes

Cited by 16 publications

References 41 publications

Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients

Role of the Soluble Receptor for Advanced Glycation End Products (sRAGE) as a Prognostic Factor for Mortality in Hemodialysis and Peritoneal Dialysis Patients

The poly-omics of ageing through individual-based metabolic modelling

Advanced Glycation End Products (AGEs): Biochemistry, Signaling, Analytical Methods, and Epigenetic Effects

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