Factors associated with depressive symptoms in uncontrolled asthmatics

Mangold, Rita A.; Salzman, Gary; Williams, Karen; Hanania, Nicola A.

doi:10.1080/02770903.2017.1350968

Cited by 6 publications

(4 citation statements)

References 32 publications

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“…It was further observed that 26.8% of asthma patients had moderate to severe depression. In studies conducted before the pandemic, the prevalence of depression in asthma patients was significantly higher than in the healthy group [7,17,22,23]. In fact, the prevalence of depression we found in asthma patients during the pandemic was considerably higher than in studies conducted before the pandemic.…”

Section: Discussioncontrasting

confidence: 52%

Evaluation of anxiety and depression in asthma patients during the COVID-19 pandemic

Eroğlu¹,

Yıldız²

2022

j-ebr

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Section: Discussioncontrasting

confidence: 52%

Evaluation of anxiety and depression in asthma patients during the COVID-19 pandemic

Eroğlu¹,

Yıldız²

2022

j-ebr

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“…On the other hand, depression is cited as factor affecting patients' subjective evaluation of asthmatic symptoms; it reduces the health-related quality of life, worsens asthma management, correlates with asthma severity, and affects the asthma control status and treatment adherence [20,21]. Some findings suggest that adult patients with depressive symptoms may have a nearly twice higher risk of asthma onset than those without depression [14,22]. A longitudinal observational study by Brunner et al [23] points to depression as a marker of risk for incident adult-onset asthma in middle-aged adults.…”

Section: Discussionmentioning

confidence: 99%

Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing

Gomułka

Liebhart

Medrala

2021

JCM

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The vascular endothelial growth factor (VEGF) plays a pivotal role in process of angiogenesis in adults. If angiogenesis is not properly controlled, its deregulation may implicate it in various psychosomatic diseases states. The aim of our study was to reveal possible correlation between severity of depression in asthmatics with different degrees of airway narrowing and serum vascular endothelial growth factor levels. The study population included a total of 122 adult subjects: 82 patients with asthma (among them 42 patients with irreversible bronchoconstriction and 40 patients with reversible bronchoconstriction) and 40 healthy participants as a control group. The standardized Beck Depression Inventory (BDI) was used to estimate the depression symptoms. Enzyme-linked immunosorbent assay (ELISA) was used to assess the VEGF serum concentration in all participants. There was a significant difference in depression symptoms in asthmatics with reversible (p = 0.0432) and irreversible airway obstruction (p = 0.00005) in comparison to control group and between these two subgroups of asthmatics (p = 0.0233). Obtained results revealed significant correlation between level of depression and mean VEGF serum concentration in asthmatics with reversible airway obstruction (p = 0.0202). There was no difference between enhanced depression symptoms and VEGF serum concentration in patients with irreversible airway obstruction nor in the total group of asthmatics (in both p > 0.05). The relationship between asthma severity and depression symptoms seems to be certain. VEGF might be considered as a putative biomarker of depression in asthmatics, mainly those with reversible airway narrowing.

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“…Exercise training has shown a beneficial effect on the symptoms of anxiety and depression in meta-analyses, with greatest effects on depression [58]. A Cochrane review of exercise training in asthma concluded that exercise training-related improvements in quality of life may result in improved psychosocial well-being [59] Anxiety and depression are prevalent in asthma, particularly within difficult and severe asthma [60], and depression is related to higher levels of hospital admission, corticosteroid use [61] and poorer quality of life [62].…”

Section: Potential Mechanisms To Explain the Anti-inflammatory Effectmentioning

confidence: 99%

Defining a role for exercise training in the management of asthma

2020

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The prevalence of asthma remains high worldwide, with increasing awareness of the morbidity and mortality from asthma in low-income countries. In the UK, despite the development of biological treatments, many patients remain suboptimally controlled, and mortality rates have been static for decades. Therefore, new approaches are needed to treat asthma that are scalable at minimal cost. Exercise immunology is an expanding field, and there is growing evidence that exercise can modulate inflammatory and immune processes in asthma. Whilst exercise is encouraged in current treatment guidelines, there are no specific recommendations as to the intensity, frequency or duration of exercise exposure. Despite national and international guidance to increase exercise, patients with asthma are less likely to engage in physical activity. This review explores the disease modifying benefit of exercise in asthma. We also review the domains in which exercise exerts positive clinical effects in asthma, including the effects of exercise on symptom scores, quality of life, psychosocial health, and in the obese asthma phenotype. Finally, we review the barriers to exercise in asthma, given the benefits it confers. A better understanding of the mechanisms through which exercise exerts its positive effects in asthma may provide more accurate prescription of exercise training programmes as part of broader asthma management, with the potential of identification of new drug targets.

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Factors associated with depressive symptoms in uncontrolled asthmatics

Cited by 6 publications

References 32 publications

Evaluation of anxiety and depression in asthma patients during the COVID-19 pandemic

Evaluation of anxiety and depression in asthma patients during the COVID-19 pandemic

Vascular Endothelial Growth Factor as a Putative Biomarker of Depression in Asthmatics with Reversible Airway Narrowing

Defining a role for exercise training in the management of asthma

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