Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Pedersen, Marie; Stafoggia, Massimo; Weinmayr, Gudrun; Andersen, Zorana Jovanovic; Galassi, Claudia; Sommar, Johan Nilsson; Forsberg, Bertil; Olsson, David; Oftedal, Bente; Krog, Norun Hjertager; Aamodt, Geir; Pyko, Andrei; Pershagen, Göran; Korek, Michal; Fairé, Ulf dé; Pedersen, Nancy L.; Östenson, Claes‐Göran; Fratiglioni, Laura; Sørensen, Mette; Eriksen, Kirsten Thorup; Tjønneland, Anne; Peeters, Petra H.M.; Bueno‐de‐Mesquita, Bas; Vermeulen, Roel; Eeftens, Marloes; Plusquin, Michelle; Key, Timothy J.; Jaensch, Andrea; Nagel, Gabriële; Concin, Hans; Wang, Meng; Tsai, Ming-Yi; Grioni, Sara; Marcon, Alessandro; Krogh, Vittorio; Ricceri, Fulvio; Sacerdote, Carlotta; Ranzi, Andrea; Cesaroni, Giulia; Forastiére, Francesco; Tamayo, Ibón; Amiano, Pilar; Dorronsoro, Miren; Stayner, Leslie T.; Kogevinas, Manolis; Nieuwenhuijsen, Mark; Sokhi, Ranjeet S.; Hoogh, Kees de; Beelen, Rob; Víneis, Paolo; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole

doi:10.1016/j.euf.2016.11.008

Cited by 42 publications

(51 citation statements)

References 27 publications

(40 reference statements)

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“…10 In contrast, in ESCAPE, no association of various modeled estimates of ambient air pollution concentrations, including ambient PM 2.5 and NO 2 , and incident bladder cancer risk (n = 943) was observed. 11 There was also no association of residential PM 2.5 concentrations and mortality due to malignant neoplasms of the urinary tract (n = 155) in a cohort of elderly Hong Kong residents. 17 Strengths of the study include the assignment of ambient PM 2.5 and NO 2 concentrations based on European multicity land-use regression models specifically developed and validated for transferability to other geographical areas, 15 addressing a major limitation of previous work based on surrogate selfreported indicators of ambient air pollution with high likelihood of misclassification.…”

Section: Discussionmentioning

confidence: 90%

“…There was a significant positive association of ambient PM 2.5 concentrations, but not NO 2 or O 3 , and bladder cancer mortality in an analysis of the American Cancer Society Cancer Prevention Study‐II (CPS‐II) (hazard ratio (HR) per 4.4 μg/m 3 = 1.13 (95% CI 1.03–1.23), n = 1,324 bladder cancer deaths) . In contrast, in ESCAPE, no association of various modeled estimates of ambient air pollution concentrations, including ambient PM 2.5 and NO 2 , and incident bladder cancer risk (n = 943) was observed . There was also no association of residential PM 2.5 concentrations and mortality due to malignant neoplasms of the urinary tract (n = 155) in a cohort of elderly Hong Kong residents …”

Section: Discussionmentioning

confidence: 99%

“…Other studies with either measured or modeled estimates of ambient air pollution concentrations have also reported positive associations with bladder cancer, though there are limitations in some studies including a lack of data on cigarette smoking history, small numbers of observed cases, or the use of fatal rather than incident disease . In contrast, a recent analysis of the European Study of Cohorts for Air Pollution Effects project (ESCAPE) reported no evidence for an association …”

Section: Introductionmentioning

confidence: 99%

“…[8][9][10] In contrast, a recent analysis of the European Study of Cohorts for Air Pollution Effects project (ESCAPE) reported no evidence for an association. 11 This study seeks to further examine the association between ambient air pollution and bladder cancer risk updating previous work based on city size and proximity to traffic in the Spanish Bladder Cancer Study by assigning estimates of ambient air pollution concentrations from a European land-use regression model developed as part of the ESCAPE project to the residential address of study participants. The Spanish Bladder Cancer Study is a large case-control study including data on 1,219 incident bladder cancer cases and 1,271 hospital controls.…”

Section: Introductionmentioning

confidence: 99%

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Ambient air pollution and incident bladder cancer risk: Updated analysis of the Spanish Bladder Cancer Study

Turner

Gràcia-Lavedán

Cirac

et al. 2019

Intl Journal of Cancer

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Although outdoor air pollution and particulate matter in outdoor air have been consistently linked with increased lung cancer risk, the evidence for associations at other cancer sites is limited. Bladder cancer shares several risk factors with lung cancer and some positive associations of ambient air pollution and bladder cancer risk have been observed. This study examined associations of ambient air pollution and bladder cancer risk in the large‐scale Spanish Bladder Cancer Study. Estimates of ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2) concentrations were assigned to the geocoded participant residence of 938 incident bladder cancer cases and 973 hospital controls based on European multicity land‐use regression models. Adjusted odds ratios (ORs) and 95% confidence intervals (CI) for associations of ambient air pollution and bladder cancer risk were estimated using unconditional logistic regression models. Overall, there was no clear association between either ambient PM2.5 (OR per 5.9 μg/m3 = 1.06, 95% CI 0.71–1.60) or NO2 (OR per 14.2 μg/m3 = 0.97, 95% CI 0.84–1.13) concentrations and incident bladder cancer risk. There was no clear evidence for effect modification according to age group, sex, region, education, cigarette smoking status, or pack‐years. Results were also similar among more residentially stable participants and in two‐pollutant models. Overall, there was no clear evidence for associations of ambient PM2.5 and NO2 concentrations and incident bladder cancer risk. Further research in other large‐scale population studies is needed with detailed information on measured or modeled estimates of ambient air pollution concentrations and individual level risk factors.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ambient air pollution and incident bladder cancer risk: Updated analysis of the Spanish Bladder Cancer Study

Turner

Gràcia-Lavedán

Cirac

et al. 2019

Intl Journal of Cancer

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“…They found no association between them. Pedersen et al, (2016) in their study examined if there is a relationship between ambient air pollution and the problem of cancer of the bladder in European countries. Their results showed no evidence in support of that.…”

Section: Introductionmentioning

confidence: 99%

On the Conditional Effect of Particulate Matter on Cancer Mortality in OECD Countries

Anani¹

2017

Int.J.Curr.Res.Aca.Rev.

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Article InfoGiven the adverse effects of air pollution on human health, a lot of studies have empirically investigated the causal effect of air pollution on health. However, no study has considered how fine particulate matter interacts with GDP per capita to affect cancer mortality. This study therefore uses data for 20 OECD countries to estimate the conditional effect of air pollution on cancer mortality. To this end, a fixed effect panel regression model which takes both country and time fixed effects into consideration is estimated. The conditional causal effect of fine particulate matter was found to be negative 0.22 and significant at 1% level.

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Air pollution and incident bladder cancer: A risk assessment

Kawada

2019

Intl Journal of Cancer

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Dear editor, I have read with interest the article entitled "Ambient air pollution and incident bladder cancer risk: Updated analysis of the Spanish Bladder Cancer Study" by Turner et al. 1 that evaluated the association between ambient particulate matter within a diameter of 2.5 (PM2.5), nitrogen dioxide (NO 2 ) and bladder cancer incidence. Although there were no significant associations of ambient PM2.5 and NO 2 concentrations with incident bladder cancer, some cautions should be paid to the methodology of their research.First, the authors adopted single pollutant and two pollutant models by using estimation data from residential areas and a dependent variable was personal information on incident bladder cancer. As there is a variation of ambient PM2.5 and NO 2 within the same study area, individual exposure levels of ambient PM 2.5 and NO 2 should be used instead of estimated values, although there are difficulties of measuring individual data.Second, the authors adopted unconditional logistic regression models for the analysis. I suppose that case-control matching data were canceled and conservative results would be derived by their statistical procedure. 2 Although there are some stronger factors than air pollutions for incident bladder cancer, conditional logistic regression models can be applied to case-control matching data.Finally, the authors cited a meta-analysis of cohort studies, presenting no significant association between air pollution and incident bladder cancer. The air pollution data were gathered by the same method, and I speculate that personal lifestyle factors would greatly contribute to the risk of bladder cancer. 3,4 Yours sincerely Tomoyuki Kawada References 1. Turner MC, Gracia-Lavedan E, Cirac M, et al. Ambient air pollution and incident bladder cancer risk: updated analysis of the Spanish bladder cancer study. Int J Cancer 2019;145:894-900. 2. Pedersen M, Stafoggia M, Weinmayr G, et al. Is there an association between ambient air pollution and bladder cancer incidence? Analysis of 15 European cohorts. Eur Urol Focus 2018;4:113-20. 3. Cumberbatch MGK, Jubber I, Black PC, et al. Epidemiology of bladder cancer: a systematic review and contemporary update of risk factors in 2018. Eur Urol 2018;74:784-95. 4. Kwan ML, Garren B, Nielsen ME, et al. Lifestyle and nutritional modifiable factors in the prevention and treatment of bladder cancer.

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Is There an Association Between Ambient Air Pollution and Bladder Cancer Incidence? Analysis of 15 European Cohorts

Cited by 42 publications

References 27 publications

Ambient air pollution and incident bladder cancer risk: Updated analysis of the Spanish Bladder Cancer Study

Ambient air pollution and incident bladder cancer risk: Updated analysis of the Spanish Bladder Cancer Study

On the Conditional Effect of Particulate Matter on Cancer Mortality in OECD Countries

Air pollution and incident bladder cancer: A risk assessment

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