GATA2 gene analysis in several forms of hematological malignancies including familial aggregations

Hamadou, Walid Sabri; Mani, Rahma; Besbes, Sawsen; Bourdon, Violaine; Youssef, Yosra Ben; Eisinger, François; Mari, Véronique; Gesta, Paul; Dreyfus, Hélène; Bonadona, Valérie; Dugast, Catherine; Zattara, Hélène; Faivre, Laurence; Noguchi, T; Khélif, Abderrahim; Sobol, Hagay; Soua, Zohra

doi:10.1007/s00277-017-3076-9

Cited by 7 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Increasing evidence has shown that GATA2 expression is correlated with hematologic pathophysiologies and the proliferation and progression of solid tumors [40]. Upregulated GATA2 expression has been implicated in several tumour types, such as breast cancer [41], colorectal cancer [42] and liver cancer [43]. Moreover, recent studies confirmed that GATA2 overexpression in prostate cancer increases cellular motility and invasiveness, proliferation, tumorigenicity, and resistance to standard therapies [40].…”

Section: Discussionmentioning

confidence: 98%

Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer

et al. 2022

View full text Add to dashboard Cite

Accumulated studies have provided controversial evidences of expression patterns and prognostic value of the GATA family in human ovarian cancer. In the present study, we accessed the distinct expression and prognostic roles of 7 individual members of GATA family in ovarian cancer (OC) patients through Oncomine analysis, CCLE analysis, Human Protein Atlas (HPA), Kaplan–Meier plotter (KM plotter) database, cBioPortal and Metascape. Our results indicated that GATA1, GATA3, GATA4 and TRPS1 mRNA and protein expression was significantly higher in OC than normal samples. High expression of GATA1, GATA2, and GATA4 were significantly correlated with better overall survival (OS), while increased GATA3 and GATA6 expression were associated with worse prognosis in OC patients. GATA1, GATA2, GATA3 and GATA6 were closely related to the different pathological histology, pathological grade, clinical stage and TP53 mutation status of OC. The genetic variation and interaction of the GATA family may be closely related to the pathogenesis and prognosis of OC, and the regulatory network composed of GATA family genes and their neighboring genes are mainly involved in Notch signaling pathway, Th1 and Th2 cell differentiation and Hippo signaling pathway. Transcriptional GATA1/2/3/4/6 could be prognostic markers and potential therapeutic target for OC patients.

show abstract

Section: Discussionmentioning

confidence: 98%

Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Neither the case described by us nor those presented by other investigators explains the relationship between GATA2 haploinsufficiency and the development of lymphoblastic neoplasms. Several authors have attempted to find a deleterious GATA2 mutation in familial and sporadic cases of lymphoblastic tumors (3,16). Collin et al suggested that the GATA2 transcription factor plays not only an important role in early hematopoiesis, but it can also affect B cell differentiation (17).…”

Section: Discussionmentioning

confidence: 99%

Case report: Successful allogeneic stem cell transplantation in a child with novel GATA2 defect associated B-cell acute lymphoblastic leukemia

Heropolitańska-Pliszka

Piątosa

Szmydki‐Baran

et al. 2022

Front. Immunol.

View full text Add to dashboard Cite

GATA-binding protein 2 (GATA2) is a transcription factor responsible for the regulation of blood cell proliferation, differentiation, and maintenance in hematopoietic stem cells. Here, we describe successful bone marrow transplantation in a carrier of a novel GATA2 pathogenic variant who was diagnosed with immunodeficiency a few years after completion of B-cell precursor acute lymphoblastic leukemia (BCP-ALL) treatment. At the age of 4 years, the patient was diagnosed with and treated for BCP-ALL. Antileukemic therapy was complicated by pulmonary cryptococcosis. Two years after completion of the maintenance therapy, the child was consulted by an immunologist because of recurrent respiratory tract infections and an episode of sepsis. Flow cytometry revealed deep monocytopenia, lymphopenia, absence of B lymphocytes, considerably reduced NK cells, poor thymic T lymphocyte production, minor defects in T cell maturation, and absence of TCRγδ+ T cells. The presence of the likely pathogenic, heterozygous missense variant within exon 5 of GATA2 (NM_032638.5: c.1047T>G, Cys349Trp) was identified in the proband and confirmed in the father of the patient, who underwent allogeneic hematopoietic stem cell transplantation (HSCT) from a matched unrelated donor due to myelodysplastic syndrome with excess blasts at the age of 22 years. An allogeneic hematopoietic stem cell transplantation with a reduced toxicity conditioning protocol was performed using a matched sibling donor. Pre-transplant conditioning included fludarabine (5 × 30 mg/m2), treosulfan (3 × 14 g/m2), and thiotepa (10 mg/kg). Complete donor chimerism was achieved on post-transplant day 17. During the 12 months of the posttransplant observation period, she remained free from symptoms of acute or chronic graft-versus-host disease, and immunosuppressive treatment was therefore stopped. This is the second reported case of BCP-ALL in a patient with GATA2 deficiency, and the first successfully treated with a reduced-toxicity conditioning HSCT protocol. The co-occurrence of lymphoid malignancies and primary immunodeficiencies points to the role of genetic counseling and family screening for possible cancer predisposition syndromes prior to the selection of related HSCT donors.

show abstract

“…Increasing evidence has shown that GATA2 expression is correlated with hematologic pathophysiologies and the proliferation and progression of solid tumors [40]. Upregulated GATA2 expression has been implicated in several tumour types, such as breast cancer [41], colorectal cancer [42] and liver cancer [43]. Moreover, recent studies con rmed that GATA2 overexpression in prostate cancer increases cellular motility and invasiveness, proliferation, tumorigenicity, and resistance to standard therapies [40].…”

Section: Discussionmentioning

confidence: 99%

Distinct Expression and Prognostic Values of GATA Transcription Factor Family in Human Ovarian Cancer.

Zhou

Huai-jie

Zuo

et al. 2020

Preprint

View full text Add to dashboard Cite

Accumulated studies have provided controversial evidences of expression patterns and prognostic value of the GATA transcription factor family in human ovarian cancer. In the present study, we accessed the distinct expression and prognostic roles of 7 individual members of GATA family in ovarian cancer (OC) patients through Oncoming analysis, CCLE analysis, the Kaplan–Meier plotter (KM plotter) database, cBioPortal and Metascape. Our results indicated that GATA1, GATA3, GATA4 and TRPS1 mRNA expression was significantly higher in OC than normal samples. High expression of GATA1, GATA2, and GATA4 were significantly correlated with better overall survival (OS), while increased GATA3 and GATA6 expression were associated with worse prognosis in OC patients. GATA1, GATA2, GATA3 and GATA6 were closely related to the diﬀerent clinicopathological features of OC. The genetic variation and interaction of the GATA family may be closely related to the pathogenesis and prognosis of OC, and the regulatory network composed of GATA family genes and their neighboring genes are mainly involved in Notch signaling pathway, Th1 and Th2 cell differentiation and Hippo signaling pathway. Our results might be beneficial for the better understanding of heterogeneity and complexity in the molecular biology of ovarian cancer, and paving a way for more accurate prediction of the prognosis of patients with OC.

show abstract

GATA2 gene analysis in several forms of hematological malignancies including familial aggregations

Cited by 7 publications

References 28 publications

Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer

Distinct expression and prognostic values of GATA transcription factor family in human ovarian cancer

Case report: Successful allogeneic stem cell transplantation in a child with novel GATA2 defect associated B-cell acute lymphoblastic leukemia

Distinct Expression and Prognostic Values of GATA Transcription Factor Family in Human Ovarian Cancer.

Contact Info

Product

Resources

About