Drug-Induced Dental Caries: A Disproportionality Analysis Using Data from VigiBase

Abstract

We identified 88 drugs with a significant positive disproportionality for dental caries. Special attention has to be paid to bisphosphonates, atropinic drugs, immunosuppressants and drugs causing hyperglycaemia.

Validating a model for medication‐related dental outcomes in older people

“…Opioids and antidepressants were found to be significantly associated with risk of dental intervention in the non‐dementia cohort only. Opioids (e.g., oxycodone and morphine) have been reported to induce dry mouth and dental caries (de Campaigno et al., 2017). Caries development may also be induced through hyperglycemia and alterations to salivary pH (de Campaigno et al., 2017).…”

“…Opioids (e.g., oxycodone and morphine) have been reported to induce dry mouth and dental caries (de Campaigno et al., 2017). Caries development may also be induced through hyperglycemia and alterations to salivary pH (de Campaigno et al., 2017). Opioid use may also mask pain associated with oral disease or indicate poor overall health associated with chronic pain (Domenichiello & Ramsden, 2019), both of which may increase need for dental intervention.…”

“…In addition, our study did not take into consideration medication doses, nor whether duration of use exceeded the three‐year exposure period. Finally, our study focused on the xerogenic effects of medications and their association with dental health outcomes; however, other potential mechanisms may impact on dental health but investigating these was beyond the scope of this study (de Campaigno et al., 2017).…”

“…Medications can impact salivary gland function, leading to perceived oral dryness (xerostomia) and reduced salivary secretion (hyposalivation) (Wolff et al., 2017). If left untreated, dry mouth may lead to the development of caries and tooth loss (de Campaigno et al., 2017). Given that multimorbidity and polypharmacy are prevalent in older people (Wastesson et al., 2018), the impact of xerogenic medications on dental health is an important area of investigation in this population.…”

The influence of drugs used in mental disorders on the health of the oral cavity - a systematic review

“…W 2014 roku w Niemczech opisano przypadek ostrego obustronnego zapalenia ślinianki przyusznej, będącego efektem wtargnięcia drobnoustrojów do przewodu Stenona w następstwie hiposaliwacji wywołanej terapią wenlafaksyną [22]. Podobne skutki wiąże się z przyjmowaniem niektórych leków przeciwpsychotycznych (neuroleptycznych): klomipraminy i fenotiazyny oraz TCA: amitryptyliny [22,23] i trimipraminy [22].…”