American cutaneous leishmaniasis in infancy and childhood

Paniz‐Mondolfi, Alberto; Talhari, Carolina; Bustos, María Fernanda García; Rosales, Tamara; Villamil-Gómez, Wilmer E.; Márquez, M. Carmen; Alvarez, A.; Sánchez, Alejandra I. Tálamo; Rodríguez‐Morales, Alfonso J.

doi:10.1111/ijd.13664

Cited by 24 publications

(16 citation statements)

References 123 publications

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“…Information on disease burden, clinical spectrum and efficacy of treatment in pediatric CL remains scarce. In our cohort, 3/5 children lived in particular exposed areas, near gold mining sites with active deforestation drawing vectors closer to human dwellings [ 43 ]. The presence of an intra-familial CL case was found to be an important risk factor in the literature [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Leishmania naiffi and lainsoni in French Guiana: Clinical features and phylogenetic variability

Ducharme¹,

Simon²,

Ginouvès³

et al. 2020

PLoS Negl Trop Dis

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In French Guiana, five species are associated with Cutaneous Leishmaniasis (CL). Though infections with Leishmania guyanensis, L. (V.) braziliensis and L. (L.) amazonensis have been extensively described, there are few available clinical and genetic data on L. (V.) lainsoni and L. (V.) naiffi. We determined the clinical and epidemiological features of all cases of CL due to L. (V.) naiffi and L. (V.) lainsoni diagnosed in French Guiana between 2003 and 2019. Phylogenetic analysis was performed by sequencing a portion of HSP70 and cyt b genes. Five cases of L. naiffi and 25 cases of L. lainsoni were reported. Patients infected by L. (V.) lainsoni were usually infected on gold camps, mostly along the Maroni river (60%), while L. naiffi was observed in French patients infected on the coast (100%). A high number of pediatric cases (n = 5; 20%) was observed for L. (V.) lainsoni. A mild clinical course was observed for all cases of L. (V.) naiffi. HSP70 and cyt b partial nucleotide sequence analysis revealed different geographical clusters within L. (V.) naiffi and L. (V.) lainsoni but no association were found between phylogenetic and clinical features. Our data suggest distinct socio-epidemiological features for these two Leishmania species. Patients seem to get infected with L. (V.) naiffi during leisure activities in anthropized coastal areas, while L. (V.) lainsoni shares common features with L. (V.) guyanensis and braziliensis and seems to be acquired during professional activities in primary forest regions. Phylogenetic analysis has provided information on the intraspecific genetic variability of L. (V.) naiffi and L. (V.) lainsoni and how these genotypes are distributed at the geographic level.

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Section: Discussionmentioning

confidence: 99%

Leishmania naiffi and lainsoni in French Guiana: Clinical features and phylogenetic variability

Ducharme¹,

Simon²,

Ginouvès³

et al. 2020

PLoS Negl Trop Dis

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“…1 Although less commonly affected than adults, children represent a uniquely vulnerable population, given their propensity for outdoor activities. 2 The presentation and course of disease vary greatly depending on the patient's immune status and the infecting species, which are classified according to geographic distribution.…”

Section: Cutaneous Leishmaniasis In a Boy From Belizementioning

confidence: 99%

“…However, immunocompromised individuals may succumb to a disseminated form of cutaneous disease that, in severe cases, also can affect the mucosa. 2 Diagnosis can be achieved through visualization of Leishmania amastigotes within histiocytes (Leishman-Donovan bodies). 3 However, identification of these structures can prove difficult.…”

Section: Cutaneous Leishmaniasis In a Boy From Belizementioning

confidence: 99%

“…Thus, some have advocated for a period of observation before initiation of therapy. 2 Following conservative treatment, with careful wound care and close follow-up, the lesions improved at both 1 (Figure 2; available at www.jpeds.com) and 3 months (Figure 3; available at www.jpeds.com), and the patient developed no evidence of mucosal disease. ■…”

Section: Cutaneous Leishmaniasis In a Boy From Belizementioning

confidence: 99%

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Cutaneous Leishmaniasis in a Boy from Belize

Pollack

Flowers

Zlotoff

2019

The Journal of Pediatrics

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“…Eine kausale Therapie, die zum frühzeitigen Abtöten der Larven führt, kann mittels einer Einmalgabe von Ivermectin (200 µg/kg KG), das aber in Deutschland für diese Indikation nicht zugelassen ist, durchgeführt werden [16,17]. Eine Alternative bestünde in der lokalen oder besser systemischen Applikation von Albendazol ( [18,19] (▶ Abb. 4).…”

Section: Larva Cutanea Migransunclassified

Hautinfektionen durch Insektenstiche nach Fernreisen bei Kindern

Kleine¹,

Ziegler²,

Schwienhorst-Stich³

et al. 2019

Kinder- und Jugendmedizin

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ZusammenfassungNach Fernreisen in die Tropen und Subtropen finden sich als Grund für einen Arztbesuch neben den klassischen vektorübertragenen Erkrankungen wie Malaria oder Denguefieber und der Reisediarrhö auch zu ca. 20 % neu aufgetretene dermatologische Erkrankungen. Ursächlich ist meistens der Kontakt der Haut und Schleimhäute mit Insekten durch Biss oder Stich mit einer meist juckenden Lokalreaktion und der Gefahr einer bakteriellen Superinfektion. Einige Insektenarten dienen als Vektoren für systemische Infektionen sowie lokale Hautparasitosen, andere zeigen sich als Ektoparasitosen. Die Erregerspezies von nach Fernreisen neu aufgetretenen Hautveränderungen sind vielfältig, oft ist das Spektrum der Erreger weltweit verbreitet und somit nicht speziell auf Fernreisen bezogen. Es finden sich aber auch Infektionen, die je nach Reisestil, Reisedauer, und vor allem Reiseregion in unterschiedlicher Häufung und Wahrscheinlichkeit auftreten können. Die Hautinfektionen bei Kindern unterscheiden sich nur gering von denen bei Erwachsenen. Körpergröße, Sozial- und Spielverhalten haben jedoch einen wesentlichen Einfluss auf die Häufigkeit spezieller Hautinfektionen bei Kindern nach Fernreisen. Wichtigste Form der Krankheitsvermeidung ist die Prävention eines Kontaktes mit Insekten. In diesem Artikel soll dem niedergelassenen Pädiater und Kliniker eine Kurzübersicht und Empfehlung gegeben werden, um den wichtigsten reiseassoziierten infektiologischen Hautmanifestationen bei Kindern im Alltag zu begegnen.

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American cutaneous leishmaniasis in infancy and childhood

Cited by 24 publications

References 123 publications

Leishmania naiffi and lainsoni in French Guiana: Clinical features and phylogenetic variability

Leishmania naiffi and lainsoni in French Guiana: Clinical features and phylogenetic variability

Cutaneous Leishmaniasis in a Boy from Belize

Hautinfektionen durch Insektenstiche nach Fernreisen bei Kindern

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