2017
DOI: 10.1111/age.12574
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Identification of positive selection signatures in pigs by comparing linkage disequilibrium variances

Abstract: Selection affects the patterns of linkage disequilibrium (LD) around the site of a beneficial allele with an increase in LD among the hitchhiking alleles. Comparing the differences in regional LD between pig populations could help to identify putative genomic regions with potential adaptations for economic traits. In this study, using Illumina Porcine SNP60K BeadChip genotyping data from 207 Chinese indigenous, 117 South American village and 408 Large White pigs, we estimated the variation of genome-wide LD be… Show more

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Cited by 9 publications
(8 citation statements)
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“…The most frequent long ROH island in Western pig breeds contained the ADAMTSL3 gene, which was previously identified as having a strong selection signal for body length in Yorkshire pigs (Li et al . ). Correspondingly, a reproduction‐trait‐related gene, PRM1, was included in the Chinese pigs’ most significant long ROH island, which was discovered in a region with high haplotype similarity shared among Chinese indigenous pigs (Wang et al .…”
Section: Discussionmentioning
confidence: 97%
“…The most frequent long ROH island in Western pig breeds contained the ADAMTSL3 gene, which was previously identified as having a strong selection signal for body length in Yorkshire pigs (Li et al . ). Correspondingly, a reproduction‐trait‐related gene, PRM1, was included in the Chinese pigs’ most significant long ROH island, which was discovered in a region with high haplotype similarity shared among Chinese indigenous pigs (Wang et al .…”
Section: Discussionmentioning
confidence: 97%
“…We found the ADAMTS Like 3 (ADAMTSL3) gene at 52-53 Mb on SSC7. ADAMTSL3 is a member of the ADAMTS superfamily of proteins, and this gene was previously reported as a candidate gene for body length in Large White pigs (Li et al, 2017) and height in humans (Weedon et al, 2008). In addition, we located the Cytoplasmic Polyadenylation Element Binding Protein 1 (CPEB1) gene at 52-53 Mb on SSC7.…”
Section: Discussionmentioning
confidence: 99%
“…These genes may have played a crucial role in duck domestication by altMangmoolering glucose and lipid metabolism. Differences in glucose and lipid metabolism between wild and domesticated animals due to directional selection were also observed in pigs [25] and chickens [3]. Enpp3 and Prkar2b were identi ed as the targets of selection during the domestication of Pekin ducks and other indigenous Chinese ducks [26,27].…”
Section: Selection For Domesticationmentioning
confidence: 96%