Alterations in cortical thickness in nonmedicated premature ejaculation patients: A morphometric MRI study

Guo, Fan; Xi, Yi‐Bin; Gao, Ming; Liu, Lin; Fei, Ningbo; Qin, Wei; Li, Chen; Cui, Long‐Biao; Yan, Fei; Lei, Yu; Yuan, Jianlin; Yin, Hong

doi:10.1002/jmri.25808

Cited by 24 publications

(20 citation statements)

References 40 publications

(85 reference statements)

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“…In addition, PE patients had a significantly decreased functional connectivity in the left thalamus and caudate involving the serotonergic pathways (Zhang et al ., ; Yang et al ., ; Xu et al ., ). Several neuroimaging studies had identified a complex set of brain regions involved in the processing of sexual behavior, such as the amygdala, pallidum, thalamus and caudate nucleus (Zhang et al ., ; Chen et al ., ,b; Guo et al ., ; Lu et al ., ; Yang et al ., ; Xu et al ., ). These brain structures occupied a pivotal position in the brain network, as they were regions involved in the control of sexual response.…”

Section: Discussionmentioning

confidence: 99%

“…Brain structures including medial pre‐optic area (MPOA) of the hypothalamus regulated ejaculation and played a pivotal role in the control of ejaculation (Nutsch et al ., ; Will et al ., , ). Brain imaging studies in humans had found that a larger network of the brain or cerebral circuits and various neurotransmitters and receptor subtypes involved in the regulation and control of ejaculation (Guo et al ., ; Lu et al ., ; Xu et al ., ).…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, male sexual disorders had become a topic of interest in many animal and clinical studies, especially premature ejaculation (PE). Non‐invasive brain imaging methods, like functional or structural magnetic resonance imaging (MRI), were used to explore the brain functional and structural changes of PE (Guo et al ., ; Lu et al ., ; Xu et al ., ). Altered neural activation was found in the insula, temporal cortex and supplementary motor area in the brain of PE during viewing visual erotic stimulation (Zhang et al ., ; Lu et al ., ; Yang et al ., ).…”

Section: Introductionmentioning

confidence: 99%

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Graph analysis of DTI‐based connectome: decreased local efficiency of subcortical regions in PE patients with high sympathetic activity

Chen

Xiao-hong

et al. 2019

Andrology

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Introduction Hyperactivity of the sympathetic nervous system was considered as one of the factors involved in the pathological mechanisms of premature ejaculation (PE). Sympathetic skin response of the penis (PSSR) was used to evaluate the activity of sympathetic innervations in the penis, which was controlled by the central nervous system (brain). Shorter PSSR was found in PE patients; however, little was known regarding the central neural mechanisms of PE patients with high sympathetic activity. Methods PSSR of PE patients was evaluated, and diffusion tensor images of participants were collected. Graph theoretical analysis was employed to examine the differences of the topological properties of structural brain connectome between PE patients with high sympathetic activity and healthy controls (HCs). Moreover, the relationships between topological characteristics and clinical features in PE patients were also explored. Results Decreased local efficacy was found in the left amygdala, right pallidum and thalamus in the white matter brain networks of PE when compared with HC (survived false discovery rate (FDR) correction). In addition, PE patients showed decreased global efficacy in the left amygdala and right rolandic operculum, supramarginal gyrus, heschl gyrus, inferior temporal gyrus, pallidum and thalamus; however, these results did not survive FDR correction. Finally, the local efficacy of right thalamus had a positive correlation with the premature ejaculation diagnostic tool (PEDT) scores, while the local efficacy of left amygdala was negatively associated with the state score of the state‐trait anxiety inventory (STAI) and penile shaft sensory threshold. Conclusion The results highlighted the abnormal topological properties of structural brain connectome in PE with high sympathetic activity. We also suggested that the clinical features of PE were related to the abnormality of several brain regions involved in the central control of ejaculation and emotion. This study provided new insights into the central neural mechanisms of PE, which might offer biological markers for understanding the physiopathology of PE.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Graph analysis of DTI‐based connectome: decreased local efficiency of subcortical regions in PE patients with high sympathetic activity

Chen

Xiao-hong

et al. 2019

Andrology

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“…Since the use of the central dopaminergic and serotonergic systems as pharmacological targets for LPE treatment, there has been increasing interest in the neurobiological mechanisms of LPE. However, human data are still limited, except for several electroencephalography and neuroimaging studies detecting abnormal spontaneous and evoked brain activation responses to erotic stimuli, brain structure changes in PE patients (Hyun et al, 2008 ; Kwon et al, 2011 ; Guo et al, 2017 ; Zhang et al, 2017 ). Our findings provide a new understanding of the neural mechanism of LPE from an inhibition control perspective.…”

Section: Discussionmentioning

confidence: 99%

Central Neural Correlates During Inhibitory Control in Lifelong Premature Ejaculation Patients

Yang

Gao

Zhang

et al. 2018

Front. Hum. Neurosci.

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Lifelong premature ejaculation (LPE) is a common male sexual dysfunction. Lack of active control for rapid ejaculation brought great distress to sexual harmony and even fertility. Previous neurophysiology studies revealed an ejaculation-related control mechanism in the brain. However, it remains unclear whether this inhibitory network is altered in LPE patients. The present study investigated the central inhibitory network function of LPE patients by using stop signal task (SST)-related functional magnetic resonance imaging (fMRI) and resting-state functional connectivity (FC) analysis. The results showed no difference in task-related behavioral performance or neural activation during response inhibition between LPE patients and controls. However, LPE patients showed a significantly different correlation pattern between the stop signal reaction time (SSRT) and left inferior frontal gyrus (IFG) activation during successful inhibition, in which a typical negative correlation between SSRT and the activation was completely disappeared in patients. In addition, using the left IFG as a seed, patients showed weaker FC between the seed and two areas (left dentate nucleus (DN) and right frontal pole) compared with controls. These data suggest that LPE patients have an abnormal brain control network, which may contribute to the reduced central control of rapid ejaculation. This study provides new insights into the neural mechanism of LPE involving the central inhibitory network, which may offer an underlying intervention target for future treatment.

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“…The raphe nuclei have the largest amount of 5‐HT neurons involved in sexual orientation and are important for sexual performance (Hillegaart, Ahlenius, & Larsson, ). Cortical activation, such as visual and auditory impulses, is also closely connected to ejaculation (Guo et al, ; Mallick, Tandon, Jagannathan, Gulia, & Kumar, ). The hypothalamic, thalamic and hippocampus have differential activation when receiving sexual stimulation (Coolen, Peters, & Veening, ; Heeb & Yahr, ).…”

Section: Introductionmentioning

confidence: 99%

Changes in sexual performance and biochemical characterisation of functional neural regions: A study in serotonin transporter knockout male rats

et al. 2019

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To explore the correlation between SERT expression and sexual activities and seek the possible mechanism of SERT in regulating ejaculations, we analysed the sexual activities and biochemical characteristics of five measured neural regions in three rat genotypes (SERT−/−, SERT+/− and SERT+/+). The results showed the SERT−/− group showed fewer ejaculations and a longer ejaculation latency than the SERT+/+ group, while the SERT+/− group did not differ significantly from the SERT+/+ group in sexual performance. In addition, the SERT−/− group showed an almost complete absence of SERT mRNA and protein expression in all measured regions. In the SERT+/− group, the SERT mRNA and SERT protein expressions were downregulated by approximately 50% and 35%, respectively, compared to the SERT+/+ group. The SERT−/− group had the highest 5‐HT levels, and the 5‐HT level in the SERT+/− group was between the other two groups. Besides, the 5‐HT levels differed in almost all measured regions of the three groups. Therefore, our study confirmed that SERT played a key role in sexual performance. A certain amount of SERT protein may be critical to normal sexual performance. Hence, Polymorphisms of the SERT gene should still be highlighted for ejaculation regulation research.

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Alterations in cortical thickness in nonmedicated premature ejaculation patients: A morphometric MRI study

Abstract: 1 Technical Efficacy: Stage 3 J. Magn. Reson. Imaging 2018;47:656-662.

Cited by 24 publications

References 40 publications

Graph analysis of DTI‐based connectome: decreased local efficiency of subcortical regions in PE patients with high sympathetic activity

Graph analysis of DTI‐based connectome: decreased local efficiency of subcortical regions in PE patients with high sympathetic activity

Central Neural Correlates During Inhibitory Control in Lifelong Premature Ejaculation Patients

Changes in sexual performance and biochemical characterisation of functional neural regions: A study in serotonin transporter knockout male rats

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