Rapid divergence of histones in Hydrozoa (Cnidaria) and evolution of a novel histone involved in DNA damage response in hydra

Reddy, Puli Chandramouli; Ubhe, Suyog; Sirwani, Neha; Lohokare, Rasika; Galande, Sanjeev

doi:10.1016/j.zool.2017.06.005

Cited by 17 publications

(20 citation statements)

References 53 publications

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“…Such findings, together with the histone diversity previously described in cnidarians (Reddy, Ubhe, Sirwani, Lohokare, & Galande, 2017;Török et al, 2016) as well as in Symbiodiniaceae dinoflagellates (Lin et al, 2015), unveil the potential contribution that chromatin-associated proteins convey during epigenetic effects and inheritance linked to environmental epigenetic responses in this group (Beal et al, 2018). Along with the study of DNA meth- F I G U R E 6 (a) Characterization of histone H2A.X phosphorylation levels in staghorn coral fragments across different nutrient treatments, estimated as the ratio between phosphorylated H2A.X (gamma-H2A.X) and its nonmodified form (H2A.X).…”

Section: Discussionsupporting

confidence: 76%

“…The obtained results constitute the first description of the histone variant H2A.X and its phosphorylated form, gamma‐H2A.X, in a stony coral species. Such findings, together with the histone diversity previously described in cnidarians (Reddy, Ubhe, Sirwani, Lohokare, & Galande, ; Török et al, ) as well as in Symbiodiniaceae dinoflagellates (Lin et al, ), unveil the potential contribution that chromatin‐associated proteins convey during epigenetic effects and inheritance linked to environmental epigenetic responses in this group (Beal et al, ). Along with the study of DNA methylation levels, this work starts shaping our knowledge about the potential interactions among different epigenetic mechanisms mediating environmental responses, as well as their modulation by the combined action of different stressors (e.g., nutrients and temperature).…”

Section: Discussionsupporting

confidence: 62%

“…Only two other studies have evaluated H2A.X gene expression in marine invertebrates, with contradictory results. On one hand, increased H2A.X.1 and H2A.X.2 mRNA levels were found in Hydra exposed to the genotoxic agent bleomycin (Reddy et al, ). On the other, no expression changes were observed on variants H2A.X, H2A.Z, and macroH2A during the exposure of the Eastern oyster Crassostrea virginica to marine toxins (Gonzalez‐Romero et al, ).…”

Section: Discussionmentioning

confidence: 99%

“…On the other, no expression changes were observed on variants H2A.X, H2A.Z, and macroH2A during the exposure of the Eastern oyster Crassostrea virginica to marine toxins . Nonetheless, both studies reported increased gamma-H2A.X levels upon exposure to environmental stress Reddy et al, 2017), supporting that the main functional role of this variant during DNA repair is regulated at a post-translational level.…”

Section: Gamma-h2ax Participates In Coral Epigenetic Responses To mentioning

confidence: 93%

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Coral epigenetic responses to nutrient stress: Histone H2A.X phosphorylation dynamics and DNA methylation in the staghorn coral Acropora cervicornis

Rodríguez-Casariego

Ladd

Shantz

et al. 2018

Ecology and Evolution

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Nutrient pollution and thermal stress constitute two of the main drivers of global change in the coastal oceans. While different studies have addressed the physiological effects and ecological consequences of these stressors in corals, the role of acquired modifications in the coral epigenome during acclimatory and adaptive responses remains unknown. The present work aims to address that gap by monitoring two types of epigenetic mechanisms, namely histone modifications and DNA methylation, during a 7‐week‐long experiment in which staghorn coral fragments (Acropora cervicornis) were exposed to nutrient stress (nitrogen, nitrogen + phosphorus) in the presence of thermal stress. The major conclusion of this experiment can be summarized by two main results: First, coral holobiont responses to the combined effects of nutrient enrichment and thermal stress involve the post‐translational phosphorylation of the histone variant H2A.X (involved in responses to DNA damage), as well as nonsignificant modifications in DNA methylation trends. Second, the reduction in H2A.X phosphorylation (and the subsequent potential impairment of DNA repair mechanisms) observed after prolonged coral exposure to nitrogen enrichment and thermal stress is consistent with the symbiont‐driven phosphorus limitation previously observed in corals subject to nitrogen enrichment. The alteration of this epigenetic mechanism could help to explain the synergistic effects of nutrient imbalance and thermal stress on coral fitness (i.e., increased bleaching and mortality) while supporting the positive effect of phosphorus addition to improving coral resilience to thermal stress. Overall, this work provides new insights into the role of epigenetic mechanisms during coral responses to global change, discussing future research directions and the potential benefits for improving restoration, management and conservation of coral reef ecosystems worldwide.

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Section: Discussionsupporting

confidence: 76%

Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

Section: Gamma-h2ax Participates In Coral Epigenetic Responses To mentioning

confidence: 93%

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Coral epigenetic responses to nutrient stress: Histone H2A.X phosphorylation dynamics and DNA methylation in the staghorn coral Acropora cervicornis

Rodríguez-Casariego

Ladd

Shantz

et al. 2018

Ecology and Evolution

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“…Among marine organisms, histone H2A.Z is the most studied histone variant; structural and regulatory analyses have been performed in basal chordates, annelids, and molluscs (Arenas-Mena et al 2007, González-Romero et al 2012, Rivera-Casas et al 2016. Histone H2A.X is another variant intensively studied due to its involvement in the maintenance of genome integrity, as shown by its study in molluscs (González-Romero et al 2017) and cnidarians (Reddy et al 2017). Similarly, the presence of histone macroH2A, a variant involved in gene repression at heterochromatic regions, has also been corroborated in marine organisms (Rivera-Casas et al 2016).…”

Section: Histone Variants and Posttranslational Modificationsmentioning

confidence: 99%

Marine Environmental Epigenetics

Eirín‐López

Putnam

2019

Annu. Rev. Mar. Sci.

219

173

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Marine organisms' persistence hinges on the capacity for acclimatization and adaptation to the myriad of interacting environmental stressors associated with global climate change. In this context, epigenetics-mechanisms that facilitate phenotypic variation through genotype-environment interactions-are of great interest ecologically and evolutionarily. Our comprehensive review of marine environmental epigenetics guides our recommendations of four key areas for future research: the dynamics of wash-in and wash-out of epigenetic effects, the mechanistic understanding of the interplay of different epigenetic marks and the interaction with the microbiome, the capacity for and mechanisms of transgenerational epigenetic inheritance, and the evolutionary implications of the interaction of genetic and epigenetic features. Emerging insights in marine environmental epigenetics can be applied to critical issues such as aquaculture, biomonitoring, and biological invasions, thereby improving our ability to explain and predict the responses of marine taxa to global climate change. Expected final online publication date for the Annual Review of Marine Science Volume 11 is January 3, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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