Human papillomavirus tumour status is not associated with a positive depression screen for patients with oropharyngeal cancer

Qualliotine, Jesse R.; Califano, Joseph A.; Li, R. J.; Gold, Dorothy; Messing, Barbara; Lee, G.; Ha, Patrick K.; Fakhry, Carole

doi:10.1017/s0022215117001098

Cited by 5 publications

(9 citation statements)

References 30 publications

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“…These symptoms can include intrusive negative thoughts, avoidance of negative thoughts and behaviors, and hyperarousal symptoms (Posluszny et al, 2015). A recent retrospective study showed that 31 of 69 (44.9%) HNC patients had a positive depressive screen at diagnosis, but no obvious risk factors (including HPV status) were identified (Qualliotine et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Experiences of Head and Neck Cancer Patients in Middle Adulthood: Consequences and Coping

Grattan

Kubrak

Caine

et al. 2018

Global Qualitative Nursing Research

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The head and neck cancer (HNC) rate is rising among the middle-aged adult population. This trend has been attributed primarily to human papillomavirus exposure. An HNC diagnosis and its complex treatments may trigger life-changing physical, emotional, and social consequences. An interpretive descriptive study was conducted to describe the experiences of a purposive sample of 10 middle-aged adults who had experienced HNC. Two main themes were identified: consequences of HNC and coping with HNC. Subthemes of consequences of HNC included: voicelessness; being or looking sick; shifts in family dynamics; and sexual practices, sexual feelings, and stigma. Subthemes of coping with HNC included seeking information, discovering inner strengths, relying on a support network, establishing a sense of normalcy, and finding meaning within the experience. Supportive nursing interventions were identified by considering results from the standpoint of King’s theory of goal attainment.

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Section: Introductionmentioning

confidence: 99%

Experiences of Head and Neck Cancer Patients in Middle Adulthood: Consequences and Coping

Grattan

Kubrak

Caine

et al. 2018

Global Qualitative Nursing Research

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“…This research identified better emotional function in the patients with HPV-associated OSPCC than in the HPV-negative patients on the EORTC QLQ-C30. Qualliotine’s retrospective review of OPSCC patients (n = 69) noted that a lower proportion of HPV-associated OPSCC patients use anti-depressants [ 31 ]. Korsten prospectively compared HPV-positive and HPV-negative OPSCC patients and identified greater post-treatment emotional function in the former group using the EORTC QLQ-C30 and the EORTC Head and Neck Cancer module (EORTC QLQ-HN35) [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

“…Several other studies did not associate worsening mental health with HPV status (Qualliotine on CES-D initial screen, Rajeev-Kumar on UW-QOL, and Shinn using both the PHQ-9 and the CES-D) [ 29 , 31 , 34 ]. Shinn performed a prospective cohort study on 130 patients with OPSCC [ 34 ].…”

Section: Resultsmentioning

confidence: 99%

“…Berg and Korsten noted better emotional functioning in the HPV-positive cohort and Janz described a significant decrease in depression scores in the HPV-positive OPSCC cohort, without a significant decrease in the oral cavity cancer patients [ 28 , 30 , 33 ]. In the studies by Qualliotine, Rajeev-Kumar, and Shinn, no significant differences in mental health scores between HPV-positive versus HPV-negative cohorts were identified [ 29 , 31 , 34 ]. In the aforementioned studies, Qualliotine focused specifically on the mental health components of depression, Rajeev-Kumar on mood and anxiety, and Shinn on depression [ 29 , 31 , 34 ].…”

Section: Resultsmentioning

confidence: 99%

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Patient-Reported Outcome Measures of Psychosocial Quality of Life in Oropharyngeal Cancer Patients: A Scoping Review

Silver

Schwartz

Roy

et al. 2023

JCM

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Background: Oropharyngeal squamous cell carcinoma (OPSCC) patients are burdened by the effect of the disease process and treatment toxicities on organs important in everyday activities, such as breathing, speaking, eating, and drinking. There is a rise in OPSCC due to human papilloma virus (HPV)-associated OPSCC, affecting younger and healthier patients and with a better overall prognosis. Emphasis must be shared between oncologic outcomes and the effects on quality of life. While there have been efforts to study global and physical quality of life, the impact on psychosocial quality of life has not yet been specifically reviewed. Methods: A scoping review methodology was employed to explore the emotional, social, and mental quality of life in OPSCC patients and determine the impact of HPV status or treatment modalities. Results: Eighty-seven full-text articles were evaluated for eligibility. Fifteen articles met final inclusion criteria. The majority of the studies were conducted in the United States (n = 10) and study methodology was divided between cross-sectional (n = 6), prospective (n = 5), and retrospective studies (n = 4). Four psychosocial quality of life themes were explored: the impact on mental health and emotional wellbeing, social wellbeing and function, stress, and relationship and sexual behavior. Eighteen different patient-reported outcome measures were used, including both general head and neck oncology questionnaires and symptom-specific surveys. Conclusion: There is a paucity of research regarding the effect of OPSCC on patients’ psychosocial quality of life. Learning more about this component of quality of life can guide outreach programs and multidisciplinary involvement in improving patient care.

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“…Some patients encounter trismus and a hearing deficit, which may worsen [ 71 , 72 , 74 , 75 , 76 ]. In addition, depression is a side effect that should be followed up and not neglected [ 77 , 78 ]. Radio-osteonecrosis is also a late side effect and needs reconstruction surgery [ 71 , 72 , 74 , 75 , 76 ].…”

Section: Treatment Of Tonsillar and Base-of-tongue Cancermentioning

confidence: 99%

Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma

Näsman

Holzhauser

Kostopoulou

et al. 2021

Viruses

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The incidence of Human-papillomavirus-positive (HPV+) tonsillar and base-of-tongue squamous cell carcinoma (TSCC and BOTSCC, respectively) is increasing epidemically, but they have better prognosis than equivalent HPV-negative (HPV−) cancers, with roughly 80% vs. 50% 3-year disease-free survival, respectively. The majority of HPV+ TSCC and BOTSCC patients therefore most likely do not require the intensified chemoradiotherapy given today to head and neck cancer patients and would with de-escalated therapy avoid several severe side effects. Moreover, for those with poor prognosis, survival has not improved, so better-tailored alternatives are urgently needed. In line with refined personalized medicine, recent studies have focused on identifying predictive markers and driver cancer genes useful for better stratifying patient treatment as well as for targeted therapy. This review presents some of these endeavors and briefly describes some recent experimental progress and some clinical trials with targeted therapy.

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Human papillomavirus tumour status is not associated with a positive depression screen for patients with oropharyngeal cancer

Cited by 5 publications

References 30 publications

Experiences of Head and Neck Cancer Patients in Middle Adulthood: Consequences and Coping

Experiences of Head and Neck Cancer Patients in Middle Adulthood: Consequences and Coping

Patient-Reported Outcome Measures of Psychosocial Quality of Life in Oropharyngeal Cancer Patients: A Scoping Review

Prognostic Markers and Driver Genes and Options for Targeted Therapy in Human-Papillomavirus-Positive Tonsillar and Base-of-Tongue Squamous Cell Carcinoma

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