Comorbidity and metabolic syndrome in patients with multiple sclerosis from Asturias and Catalonia, Spain

Sicras‐Mainar, Antoni; Ruíz-Beato, Elena; Navarro‐Artieda, Ruth; Mauriño, Jorge

doi:10.1186/s12883-017-0914-2

Cited by 42 publications

(43 citation statements)

References 33 publications

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“…A considerable percentage of patients with hyperlipidaemia, especially with an elevated total cholesterol and LDL fraction, were observed in the studied group. The literature on the subject contains information regarding the negative influence of high cholesterol and triglyceride concentrations and the positive influence of an elevated HDL fraction on acute inflammatory activity [6]. Niektóre badania sugerują, że choroby współistniejące, takie jak choroby sercowo-naczyniowe, mogą przyspieszyć progresję niepełnosprawności u pacjentów z SM [7].…”

Section: Discussionunclassified

Comorbidities in multiple sclerosis

Hercuń¹,

Tomaszewski²,

Juryńczyk³

2019

Ann. Acad. Med. Siles.

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INTRODUCTION: Multiple Sclerosis (MS) is a chronic, inflammatory, demyelinating disease of the central nervous system, in which multifocal nerve tissue damage occurs. MATERIAL AND METHODS: The study analyzed the documentation of 130 patients hospitalized for multiple sclerosis in the Neurological Department of the Hospital in Bełchatów between I.2010 and V.2018. The control group were 177 patients from the Occupational Medicine Outpatient Clinic of the Medicall Health Institute in Piotrków Trybunalski consulted in 2018. RESULTS: Among patients with MS 49.2% were diagnosed with other diseases. The highest rate of comorbidity occurred in the primary progressive form and the lowest in the relapsing-remitting form. The most common diseases among MS patients were: arterial hypertension (23.8%), depression (9.2%), benign prostatic hyperplasia (7.7%), type 2 diabetes (6.9%), spinal discopathy (5.4%), cancer in anamnesis (3.8%)-2% were malignant tumors and 2% nonmalignant tumors, ischemic heart disease (3.1%), hypothyroidism (3.1%), psoriasis (3.1%), bronchial asthma (3.1%), ulcerative colitis (3.1%). Hyperlipidemia, which occurred in 35% of the subjects, was an important problem in patients with MS consisted, in the majority of cases, of elevated total and LDL cholesterol values. CONCLUSIONS: The most frequent comorbidities in MS patients are hyperlipidemia, hypertension, depression, benign prostatic hyperplasia, type 2 diabetes and spinal discopathy. The distribution of disease differed in individual forms of MS, however, this could be due to the age differences among patients. Researching the issue of comorbidity in MS is an important part of the integrated care as it can improve the treatment effectiveness in this group of patients.

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Section: Discussionunclassified

Comorbidities in multiple sclerosis

Hercuń¹,

Tomaszewski²,

Juryńczyk³

2019

Ann. Acad. Med. Siles.

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“…However, they are more or less likely to have been diagnosed with rheumatoid arthritis, lupus, psoriasis or type 1 diabetes . Other studies showed an association of ischemic heart disease, fibromyalgia, metabolic syndromes and epilepsy in the MS population compared with the general population . Mortality EMR‐based studies showed that the initial presentation by MS type (progressive MS), higher level of disability, and associated motor, sensory and cerebellar concerns are significant predictors of MS‐related mortality in a cohort of USA veterans, and suggested that MS survival is also influenced by patient comorbidities and lifestyles factors in addition to autoimmune processes .…”

Section: Use Of Electronic Medical Records In Multiple Sclerosis Resementioning

confidence: 99%

“…8 Other studies showed an association of ischemic heart disease, fibromyalgia, metabolic syndromes and epilepsy in the MS population compared with the general population. [9][10][11][12] Mortality EMR-based studies showed that the initial presentation by MS type (progressive MS), higher level of disability, and associated motor, sensory and cerebellar concerns are significant predictors of MS-related mortality in a cohort of USA veterans, 13 and suggested that MS survival is also influenced by patient comorbidities and lifestyles factors in addition to autoimmune processes. 14 Demographics data stored in EMR enabled researchers to also study differences in the incidence or prevalence of MS over time, or among different populations based on ethnicity, sex or geographic location.…”

Section: Epidemiological Studiesmentioning

confidence: 99%

Electronic medical records in multiple sclerosis research

Damotte

Gourraud

2018

Clinical & Exp Neuroim

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With the massive digitalization of many processes involved in human activities, electronic medical records (EMR) are being increasingly deployed in medical centers. EMR have the potential to become a main major real‐life data source for future medical research and evaluation of practice. Multiple sclerosis is a paradigmatic example of a complex disease that can benefit from this new source of information. Today, researchers and clinicians alike have access to tools allowing an en masse identification of multiple sclerosis patients, and extraction of demographics and clinical variables with high accuracy. However no matter how “big” the (EMR) data might be, biases are inherent to EMR data generation. These have to be studied and eventually accounted for in analysis in order to fulfill the promise of personalized medicine for all, and carrying out large clinical and research studies in multiple sclerosis.

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“…MS patients have increased cardiovascular risk even in the absence of traditional risk factors such as obesity, hypertension, type 2 diabetes or dyslipidemia suggesting disease-related factors contribute to the development of atherosclerosis in MS [2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Lipoprotein profiling in early multiple sclerosis patients: effect of chronic inflammation?

et al. 2020

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Background: Inflammatory cytokines contribute to proatherogenic changes in lipid metabolism by reduction of HDLcholesterol (HDL-C) levels, impairment of its antiinflammatory and antioxidant functions. Therefore, the protective actions of HDL-C can be limited in chronic inflammatory diseases such as multiple sclerosis (MS). The aim of this study was to assess the association between lipoprotein subfractions and inflammatory status in early stages of multiple sclerosis.Methods: Polyacrylamide gel electrophoresis Lipoprint© System was used for lipoprotein profile analysis in 19 newly diagnosed MS patients, and in matched 19 healthy controls. Serum levels of interleukin (IL) 1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12 (p70), IL-13, IL-17, granulocyte colony-stimulating factor (G-CSF), granulocyte-macrophage colonystimulating factor, interferon-γ and TNF-α were measured by multiplex bead assay. Results: Concentrations of the measured cytokines and lipoprotein subclasses were comparable between MS patients and controls. Male, but not female MS patients had significantly higher total HDL-C and small HDL-C subfraction than healthy controls. Large HDL-C negatively correlated with all measured cytokines except IL-17 in MS but not in controls.Intermediate HDL-C subfractions correlated positively with all measured cytokines except G-CSF in MS females but not in MS males or controls. Conclusion:Our results of higher HDL-C and mainly its small HDL-C subfraction suggest that male MS patients are at higher risk of atherosclerosis and the subtle dyslipidemia is present in early stages of the disease. The correlations between specific HDL-C subfractions and the inflammatory cytokines demonstrate mutual links between systemic inflammation and lipid metabolism in MS.

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Comorbidity and metabolic syndrome in patients with multiple sclerosis from Asturias and Catalonia, Spain

Cited by 42 publications

References 33 publications

Comorbidities in multiple sclerosis

Comorbidities in multiple sclerosis

Electronic medical records in multiple sclerosis research

Lipoprotein profiling in early multiple sclerosis patients: effect of chronic inflammation?

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