Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

Kumar, Sandeep; Yadav, Mayank; Yadav, Amita; Rohilla, Pooja; Yadav, Jaya Parkash

doi:10.1186/s12906-017-1883-0

Cited by 63 publications

(58 citation statements)

References 44 publications

(44 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The relative variation in parasite suppression activity among doses might be due to variation in the amount of secondary metabolites contents in the leaf latex of Aloe weloensis. This show that Aloe weloensis is endowed with a very good antimalarial activity and concordant to promising antimalarial activity of Aloe vera, Aloe pulcherrima and Aloe megalacantha in the genus Aloe (19)(20)(21). In another studies, signi cant dose-dependent parasite suppression was demonstrated after administration of Aloe macrocarpa, Aloe debrana and Aloe sinana which indicate a promising antimalarial activity and providing the scienti c evidence for the folkloric use of the plant (41,42).…”

Section: Discussionsupporting

confidence: 54%

“…The latex of Aloe weloensis leaf showed antibacterial effect against gram negative and gram positive strains (17). The leaf latex of the plant has been used in folk medicine against malarial and others human ailment in Ethiopia (18).The leaf latex and isolated compounds of Aloe vera, Aloe pulcherrima and Aloe megalacantha, a similar plant species, possessed signi cant antimalarial activity (19)(20)(21).As a result, Aloe weloensis may have similar effect as all plants belong to the same genus. Therefore, the current study was aimed to investigate antimalarial activity of the leaf latex of Aloe weloensis.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of in vitro and in vivo Antiplasmodial Activity of the Leaf Latex of Aloe Weloensis (Aloaceae)

Amare

Awgichew

Ahmed

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Nature has gifted a variety of plants having potential effect against plasmodium parasites. The present study was aimed to determine in vitro and in vivo antimalarial activity of the leaf latex of Aloe weloensis.Methods: In vitro antimalarial activity of the leaf latex of A. weloensis was determined against 3D7 strain of P. falciparum. Antimalarial activity of the three doses the latex was evaluated in 4 day-suppressive and curative models against P. berghei infected mice. Antioxidant activity of the leaf latex of A. weloensis was assessed in 2,2- diphenyl 1- picrylhydrazine assay model. Results: Antioxidant activity of the latex was concentration dependent; the strongest inhibition was measured at 400 μg/mL (73.54%). The leaf latex of A. weloensis was demonstrated inhibitory activity against 3D7 malarial strain (IC50 = 9.14 μg/ml). Suppressive and curative effect of the latex was found to be dose dependent. Parasitemia reduction was significant (200 mg/kg, p<0.01, 400 and ,600 mg/kg, p<0.001) in 4-day suppressive test compared to vehicle control. Parasitemia level of the mice treated with 200, 400 and 600 mg/kg doses of the latex significantly (p<0.001) reduced with suppression of 36%, 58% and 64% respectively in curative test. Administration of the leaf latex of A. weloensis significantly (p<0.01) improved mean survival time, pack cell volume, rectal temperature and body weight of P. berghei infected mice. Conclusion: The finding showed that the leaf latex of Aloe weloensis endowed prominent antimalarial and antioxidant activities. The result can serve as a step towards the development of safe and effective herbal therapy against plasmodium parasites.

show abstract

Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro and in vivo Antiplasmodial Activity of the Leaf Latex of Aloe Weloensis (Aloaceae)

Amare

Awgichew

Ahmed

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…A summary of the studies included in this review are discussed and presented as Tables 1 and 2. [6][7][8] In one of the studies included for review, chloroquine (CQ)-sensitive strain 3D7 and CQ-resistant strain INDO of P. falciparum were cultured in vitro on O + ve human erythrocytes and the toxicity with HeLa cells tested. The extracts of experimental plants were evaluated for their antiplasmodial activity against the culture.…”

Section: Resultsmentioning

confidence: 99%

Potent future antimalarials from Indian indigenous plants: a systematic review

Krishnaswamy¹

2019

Int J Community Med Public Health

View full text Add to dashboard Cite

Malaria has a global impact due to development of resistance against the frontline anti-malarial drugs which include artemisinin and its derivatives. According to the ancient Indian system of medicine, the Ayurveda, several Indian indigenous plants have been used for treating various ailments. The use of Indian indigenous plants for treatment of malaria is proving to be quite effective and also offers as a cheaper alternative. The purpose of this review is to obtain knowledge about the different Indian indigenous plants that have antimalarial and antiplasmodial biological activities. Literature suggests that many indigenous Indian plants have shown good antiplasmodial and antimalarial activity with effects like decrease in anaemia, weight loss and pyrexia. Hence the Indian indigenous plants have a vast scope to be used as potent future antimalarials.

show abstract

“…Moreover, aloe‐emodin showed good antiplasmodial activity in a dose‐dependent manner. The antiplasmodial EC 50 value of aloe‐emodin was 22 μg/ml (Kumar, Yadav, Yadav, Rohilla, & Yadav, ).…”

Section: Pharmacologymentioning

confidence: 99%

Aloe‐emodin: A review of its pharmacology, toxicity, and pharmacokinetics

Dong

Zeng

Liu

et al. 2019

Phytotherapy Research

323

View full text Add to dashboard Cite

Aloe-emodin is a naturally anthraquinone derivative and an active ingredient of Chinese herbs, such as Cassia occidentalis, Rheum palmatum L., Aloe vera, and Polygonum multiflorum Thunb. Emerging evidence suggests that aloe-emodin exhibits many pharmacological effects, including anticancer, antivirus, anti-inflammatory, antibacterial, antiparasitic, neuroprotective, and hepatoprotective activities. These pharmacological properties lay the foundation for the treatment of various diseases, including influenza virus, inflammation, sepsis, Alzheimer's disease, glaucoma, malaria, liver fibrosis, psoriasis, Type 2 diabetes, growth disorders, and several types of cancers. However, an increasing number of published studies have reported adverse effects of aloeemodin. The primary toxicity among these reports is hepatotoxicity and nephrotoxicity, which are of wide concern worldwide. Pharmacokinetic studies have demonstrated that aloe-emodin has a poor intestinal absorption, short elimination half-life, and low bioavailability. This review aims to provide a comprehensive summary of the pharmacology, toxicity, and pharmacokinetics of aloe-emodin reported to date with an emphasis on its biological properties and mechanisms of action.

show abstract

Antiplasmodial potential and quantification of aloin and aloe-emodin in Aloe vera collected from different climatic regions of India

Cited by 63 publications

References 44 publications

Evaluation of in vitro and in vivo Antiplasmodial Activity of the Leaf Latex of Aloe Weloensis (Aloaceae)

Evaluation of in vitro and in vivo Antiplasmodial Activity of the Leaf Latex of Aloe Weloensis (Aloaceae)

Potent future antimalarials from Indian indigenous plants: a systematic review

Aloe‐emodin: A review of its pharmacology, toxicity, and pharmacokinetics

Contact Info

Product

Resources

About