Impact of Sjogren's syndrome on Parkinson’s disease: A nationwide case-control study

Wu, Ming‐Chi; Xu, Xun; Chen, Shan Ming; Tyan, Yeu Sheng; Chiou, Jeng Yuan; Wang, Yu Hsun; Lin, Li Chi; Chen, Chyong Mei; Wei, James Cheng‐Chung

doi:10.1371/journal.pone.0175836

Cited by 16 publications

(19 citation statements)

References 30 publications

(35 reference statements)

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“…In one large epidemiological study conducted in Sweden, which involved more than 310,000 patients with different autoimmune disorders, patients with an autoimmune disease had a 33% excess risk of PD [ 9 ]. In another population-based cohort study conducted on the ethnic Chinese population from Taiwan, Sjogren syndrome was associated with an increased risk of PD [ 10 ]. In the same population, rheumatoid arthritis (RA) was also associated with an increased risk of PD, compared with age and sex-matched controls [ 11 ].…”

Section: Autoimmune Conditions and Parkinson Diseasementioning

confidence: 99%

Epidemiological Evidence for an Immune Component of Parkinson’s Disease

Gonzàlez‐Latapi

Marras

2022

JPD

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There is a growing interest in the role the immune system and inflammatory response play on the pathophysiology of Parkinson’s disease (PD). Epidemiological evidence lends support for the hypothesis that PD is an immune-mediated condition. An association between inflammatory bowel disease, including Crohn’s and Ulcerative colitis, and the risk of PD has been described and replicated in several population-based cohorts. Other autoimmune conditions, such as Sjogren syndrome, ankylosing spondylitis, and rheumatoid arthritis also seem to be associated with an increased risk of PD. Immunosuppressant medications seem to be associated with a decreased risk of PD. Finally, variants in genes involved in immune system regulation are also shared between PD and autoimmune conditions. In this review, we will provide an overview of epidemiological evidence from population-based cohort studies, meta-analyses, and genome-wide association studies that analyze the association between the immune system and PD, discuss current gaps in the literature and future research directions in this field.

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Section: Autoimmune Conditions and Parkinson Diseasementioning

confidence: 99%

Epidemiological Evidence for an Immune Component of Parkinson’s Disease

Gonzàlez‐Latapi

Marras

2022

JPD

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“…Blanc et al (2013) reported that of 25 patients with SS, 15 suffered from cognitive impairment and 5 developed dementia, revealing the risk of dementia in patients with SS. Several large sample longitudinal cohort studies with longterm follow-up (9-15 years) also confirmed that baseline SS is significantly associated with elevated risks of PD and dementia (Wu et al, 2017;Liliang et al, 2018;Chen et al, 2019;Hsu et al, 2020). Although there is evidence of an association between SS and PD and dementia, no meta-analysis has been conducted to quantitatively summarize and examine data consistency for higher-quality evidence.…”

Section: Objectivementioning

confidence: 85%

Risk of dementia or Parkinson’s disease in the presence of Sjögren’s syndrome: A systematic review and meta-analysis

Wang

Liu

Sun

et al. 2022

Front. Integr. Neurosci.

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ObjectiveEvidence from observational studies suggests that Sjögren’s syndrome (SS) may contribute to an elevated risk of Parkinson’s disease (PD) and dementia. However, few studies have been undertaken to summarize and assess the consistency of the data quantitatively. Therefore, we evaluated the risk of dementia and PD in SS patients through a systematic review and meta-analysis approach.MethodsTwo reviewers independently conducted a systematic search of PubMed, Embase, and Web of Science databases (updated to February 14, 2022) to identify published literature on the association between SS and dementia or PD. The risk estimates of dementia or PD in patients with SS were pooled using fixed or random-effects models.ResultsOf the 631 studies initially searched, 10 were eventually included. Pooled results suggested that the risk of developing dementia significantly increased in patients with SS (HR = 1.24, 95% CI: 1.15–1.33, P < 0.001), and such risk in females with SS was similar to that in males. The risk of PD was 1.36 times higher in SS (HR = 1.36, 95% CI: 1.23–1.50, P < 0.001). The association between SS and PD risk appeared to occur primarily in female patients (female: HR = 1.28, 95% CI: 1.21–1.35; P < 0.001 vs. male: HR = 1.00, 95% CI: 0.87–1.16, P = 0.962, respectively). No significant effect of age was observed on the risk of developing PD and dementia in SS patients.ConclusionOur study supports that people with SS are at higher risk of PD and dementia than the general population. Further studies are needed to elucidate the underlying mechanisms and to assess whether interventions for SS have the potential to affect dementia and PD development.

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“…Decreased corneal sensitivity in PD leads to a decrease in reflex lacrimation 30 , 37 and is further exacerbated by the frequent administration of medications with anticholinergic properties 58 , such as trihexyphenidyl and amantadine. In addition, diabetes and Sjögren's syndrome, which are considered risk factors for PD, also trigger decreased tear secretion 59 , 60 . Our meta-analysis revealed a significant, near-equivalent decrease in Schirmer test scores with or without anesthesia in the PD cohort, supporting the hypothesis that PD induces decreases in both baseline and reflex lacrimation 16 .…”

Section: Discussionmentioning

confidence: 99%

Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis

Nagino

Sung

Oyama

et al. 2022

Sci Rep

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We investigated and characterized the prevalence of dry eye disease (DED) in Parkinson’s disease (PD). PubMed and EMBASE databases were searched for relevant studies between January 1, 1979 and March 10, 2022. Quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist. Study-specific estimates were combined using the DerSimonian–Laird random-effects model. Prevalence of subjective DED symptoms in patients with PD and mean differences in blink rate, corneal thickness, tear film breakup time, and tear secretion volume on Schirmer test I were compared to those in controls. Of 383 studies, 13 (1519 patients with PD) and 12 were included in qualitative and quantitative syntheses, respectively. Meta-analysis revealed a 61.1% prevalence of subjective DED symptoms in PD and that, compared with controls, patients with PD had significantly lower blink rate, thinner corneal thickness, shorter tear film breakup time, and lower tear secretion volumes on Schirmer test I, without and with anesthesia.

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Impact of Sjogren's syndrome on Parkinson’s disease: A nationwide case-control study

Cited by 16 publications

References 30 publications

Epidemiological Evidence for an Immune Component of Parkinson’s Disease

Epidemiological Evidence for an Immune Component of Parkinson’s Disease

Risk of dementia or Parkinson’s disease in the presence of Sjögren’s syndrome: A systematic review and meta-analysis

Prevalence and characteristics of dry eye disease in Parkinson’s disease: a systematic review and meta-analysis

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